TY - JOUR

T1 - Muscle-Organ Crosstalk

T2 - The Emerging Roles of Myokines

AU - Severinsen, Mai Charlotte Krogh

AU - Pedersen, Bente Klarlund

N1 - A correction has been published: Endocrine Reviews, Volume 42, Issue 1, February 2021, Pages 97–99,

PY - 2020

Y1 - 2020

N2 - Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.

AB - Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.

KW - metabolism

KW - cytokines

KW - exercise

KW - physical activity

KW - diabetes

KW - cancer

KW - LEUKEMIA INHIBITORY FACTOR

KW - HUMAN SKELETAL-MUSCLE

KW - FOLLISTATIN-LIKE 1

KW - ADIPOSE-TISSUE

KW - PHYSICAL-ACTIVITY

KW - NEUROTROPHIC FACTOR

KW - INSULIN-RESISTANCE

KW - MESSENGER-RNA

KW - BRAIN HEALTH

KW - CARDIOMETABOLIC RISK

UR - https://doi.org/10.1210/endrev/bnaa024

U2 - 10.1210/endrev/bnaa016

DO - 10.1210/endrev/bnaa016

M3 - Review

C2 - 32393961

VL - 41

SP - 594

EP - 609

JO - Endocrine Reviews

JF - Endocrine Reviews

SN - 0163-769X

IS - 4

ER -