The role of kisspeptin and RFRP in the circadian control of female reproduction

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The role of kisspeptin and RFRP in the circadian control of female reproduction. / Beymer, Matthew; Henningsen, Jo; Bahougne, Thibault; Simonneaux, Valérie.

In: Molecular and Cellular Endocrinology, Vol. 438, 15.12.2016, p. 89-99.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Beymer, M, Henningsen, J, Bahougne, T & Simonneaux, V 2016, 'The role of kisspeptin and RFRP in the circadian control of female reproduction', Molecular and Cellular Endocrinology, vol. 438, pp. 89-99. https://doi.org/10.1016/j.mce.2016.06.026

APA

Beymer, M., Henningsen, J., Bahougne, T., & Simonneaux, V. (2016). The role of kisspeptin and RFRP in the circadian control of female reproduction. Molecular and Cellular Endocrinology, 438, 89-99. https://doi.org/10.1016/j.mce.2016.06.026

Vancouver

Beymer M, Henningsen J, Bahougne T, Simonneaux V. The role of kisspeptin and RFRP in the circadian control of female reproduction. Molecular and Cellular Endocrinology. 2016 Dec 15;438:89-99. https://doi.org/10.1016/j.mce.2016.06.026

Author

Beymer, Matthew ; Henningsen, Jo ; Bahougne, Thibault ; Simonneaux, Valérie. / The role of kisspeptin and RFRP in the circadian control of female reproduction. In: Molecular and Cellular Endocrinology. 2016 ; Vol. 438. pp. 89-99.

Bibtex

@article{66e1f130def542d18c284ab4c24bf2ae,
title = "The role of kisspeptin and RFRP in the circadian control of female reproduction",
abstract = "In female mammals, reproduction shows ovarian and daily rhythms ensuring that the timing of the greatest fertility coincides with maximal activity and arousal. The ovarian cycle, which lasts from a few days to a few weeks, depends on the rhythm of follicle maturation and ovarian hormone production, whereas the daily cycle depends on a network of circadian clocks of which the main one is located in the suprachiasmatic nuclei (SCN). In the last ten years, major progress has been made in the understanding of the neuronal mechanisms governing mammalian reproduction with the finding that two hypothalamic Arg-Phe-amide peptides, kisspeptin (Kp) and RFRP, regulate GnRH neurons. In this review we discuss the pivotal role of Kp and RFRP neurons at the interface between the SCN clock signal and GnRH neurons to properly time gonadotropin-induced ovulation. We also report recent findings indicating that these neurons may be part of the multi-oscillatory circadian system that times female fertility. Finally, we will discuss recent investigations indicating a role, and putative therapeutic use, of these neuropeptides in human reproduction.",
keywords = "Animals, Circadian Clocks/physiology, Circadian Rhythm, Female, Humans, Kisspeptins/metabolism, Models, Biological, Neuropeptides/metabolism, Reproduction/physiology",
author = "Matthew Beymer and Jo Henningsen and Thibault Bahougne and Val{\'e}rie Simonneaux",
note = "Copyright {\textcopyright} 2016. Published by Elsevier Ireland Ltd.",
year = "2016",
month = dec,
day = "15",
doi = "10.1016/j.mce.2016.06.026",
language = "English",
volume = "438",
pages = "89--99",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - The role of kisspeptin and RFRP in the circadian control of female reproduction

AU - Beymer, Matthew

AU - Henningsen, Jo

AU - Bahougne, Thibault

AU - Simonneaux, Valérie

N1 - Copyright © 2016. Published by Elsevier Ireland Ltd.

PY - 2016/12/15

Y1 - 2016/12/15

N2 - In female mammals, reproduction shows ovarian and daily rhythms ensuring that the timing of the greatest fertility coincides with maximal activity and arousal. The ovarian cycle, which lasts from a few days to a few weeks, depends on the rhythm of follicle maturation and ovarian hormone production, whereas the daily cycle depends on a network of circadian clocks of which the main one is located in the suprachiasmatic nuclei (SCN). In the last ten years, major progress has been made in the understanding of the neuronal mechanisms governing mammalian reproduction with the finding that two hypothalamic Arg-Phe-amide peptides, kisspeptin (Kp) and RFRP, regulate GnRH neurons. In this review we discuss the pivotal role of Kp and RFRP neurons at the interface between the SCN clock signal and GnRH neurons to properly time gonadotropin-induced ovulation. We also report recent findings indicating that these neurons may be part of the multi-oscillatory circadian system that times female fertility. Finally, we will discuss recent investigations indicating a role, and putative therapeutic use, of these neuropeptides in human reproduction.

AB - In female mammals, reproduction shows ovarian and daily rhythms ensuring that the timing of the greatest fertility coincides with maximal activity and arousal. The ovarian cycle, which lasts from a few days to a few weeks, depends on the rhythm of follicle maturation and ovarian hormone production, whereas the daily cycle depends on a network of circadian clocks of which the main one is located in the suprachiasmatic nuclei (SCN). In the last ten years, major progress has been made in the understanding of the neuronal mechanisms governing mammalian reproduction with the finding that two hypothalamic Arg-Phe-amide peptides, kisspeptin (Kp) and RFRP, regulate GnRH neurons. In this review we discuss the pivotal role of Kp and RFRP neurons at the interface between the SCN clock signal and GnRH neurons to properly time gonadotropin-induced ovulation. We also report recent findings indicating that these neurons may be part of the multi-oscillatory circadian system that times female fertility. Finally, we will discuss recent investigations indicating a role, and putative therapeutic use, of these neuropeptides in human reproduction.

KW - Animals

KW - Circadian Clocks/physiology

KW - Circadian Rhythm

KW - Female

KW - Humans

KW - Kisspeptins/metabolism

KW - Models, Biological

KW - Neuropeptides/metabolism

KW - Reproduction/physiology

U2 - 10.1016/j.mce.2016.06.026

DO - 10.1016/j.mce.2016.06.026

M3 - Review

C2 - 27364888

VL - 438

SP - 89

EP - 99

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

ER -

ID: 326346435