- 2021
- Published
Encephalopathy-causing mutations in G beta(1) (GNB1) alter regulation of neuronal GIRK channels
Reddy, H. P., Yakubovich, D., Keren-Raifman, T., Tabak, G., Tsemakhovich, V. A., Pedersen, M. H., Shalomov, B., Colombo, S., Goldstein, D. B., Javitch, J. A., Bera, A. K. & Dascal, N., 2021, In: iScience. 24, 9, 29 p., 103018.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, , 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling
Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells
Grunddal, Kaare Villum, Tonack, S., Egerod, Kristoffer Lihme, Thompson, J. J., Petersen, N., Engelstoft, M. S., Vagne, C., Keinse, C., Gradwohl, G., Offermanns, S. & Schwartz, Thue W., 2021, In: Molecular Metabolism. 51, 17 p., 101231.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study
Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykko, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, S. & 6 others, , 2021, In: Journal of Internal Medicine. 289, 3, p. 340-354 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Post-oral fat-induced satiation is mediated by endogenous CCK and GLP-1 in a fat self-administration mouse model
Vana, V., Lærke, M. K., Kleberg, K., Mroz, P. A., Lindberg, B. L., Ekberg, J. H., Rehfeld, Jens Frederik, Schwartz, Thue W. & Hansen, Harald S., 2021, In: Physiology and Behavior. 234, 12 p., 113315.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protective succinate-SUCNR1 metabolic stress signaling gone bad
Winther, Sally, Trauelsen, Mette & Schwartz, Thue W., 2021, In: Cell Metabolism. 33, 7, p. 1276-1278 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets
Henriksen, Nicole Lind, Hansen, S. H., Lycas, M. D., Pan, X., Eriksen, Thomas, Johansen, L. S., Sprenger, R. R., Ejsing, C. S., Burrin, D. G., Skovgaard, K., Christensen, Vibeke Brix, Thymann, Thomas & Pankratova, Stanislava, 2022, In: Physiological Reports. 10, 13, 15 p., e15368.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2
Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz
Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A. & Lane, J. R., 2022, In: Communications Biology . 5, 1, 10 p., 256.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Outrunning obesity with Lac-Phe?
Lund, Jens, Clemmensen, Christoffer & Schwartz, Thue W., 2022, In: Cell Metabolism. 34, 8, p. 1085-1087 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity
Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, Siv Annegrethe, Gerdes, V. E. A., Schwartz, Thue W., Groen, A. K., Bäckhed, F., Nielsen, J. & Nieuwdorp, M., 2022, In: iScience. 25, 8, 18 p., 104828.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
Meijnikman, A. S., van Olden, C. C., Aydin, Ö., Herrema, H., Kaminska, D., Lappa, D., Männistö, V., Tremaroli, V., Olofsson, L. E., de Brauw, M., van de Laar, A., Verheij, J., Gerdes, V. E. A., Schwartz, T. W., Nielsen, J., Bäckhed, F., Pajukanta, P., Pihlajamäki, J., Tchkonia, T., Kirkland, J. L. & 3 others, , 2022, In: Diabetes. 71, 9, p. 1929-1936 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microbiome-derived ethanol in nonalcoholic fatty liver disease
Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, , 2022, In: Nature Medicine. 28, p. 2100-2106Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
Mikkelsen, R. B., Arora, Tulika, Trošt, K., Dmytriyeva, O., Jensen, Sune K. , Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, Thomas, van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, Siv Annegrethe, Schwartz, Thue W. & Bäckhed, F., 2022, In: iScience. 25, 12, 29 p., 105683.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Jan Fahrenkrug (6/6 1947 – 10/11 2021)
Rehfeld, Jens Frederik, Hannibal, Jens, Holst, Jens Juul, Hökfelt, T., de Muckadell, O. B. S. & Schwartz, Thue W., 2022, In: Peptides. 150, 170771.Research output: Contribution to journal › Editorial › Research
- Published
Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang, X., Rönnberg, E., Säfholm, J., Thulasingam, M., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Dahlén, S. E., Nilsson, G. & Haeggström, J. Z., 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 9, p. 2677-2687Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids
Tang, X., Hou, Y., Schwartz, Thue W. & Haeggström, J. Z., 2022, In: Biochemical Pharmacology. 204, 7 p., 115208.Research output: Contribution to journal › Review › Research › peer-review
- Published
Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1–induced satiation
Vana, V., Lærke, M. K., Rehfeld, Jens Frederik, Arnold, M., Dmytriyeva, O., Langhans, W., Schwartz, Thue W. & Hansen, Harald S., 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 268-280Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers
Xu, R., Höß, C., Swiercz, J. M., Brandt, D. T., Lutz, V., Petersen, N., Li, R., Zhao, D., Oleksy, A., Creigh-Pulatmen, T., Trokter, M., Fedorova, M., Atzberger, A., Strandby, R. B., Olsen, A. A., Achiam, M. P., Matthews, D., Huber, M., Gröne, H-J., Offermanns, S. & 1 others, , 2022, In: Science Translational Medicine. 14, 654, eabf1922.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle
Abdelmoez, A. M., Dmytriyeva, O., Zurke, Y. X., Trauelsen, Mette, Marica, A. A., Savikj, M., Smith, J. A. B., Monaco, C., Schwartz, Thue W., Krook, A. & Pillon, N. J., 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 324, 4, p. E289-E298 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
Backe, M. B., Andersen, Rita Chan, Jensen, M., Jin, C., Hundahl, C., Dmytriyeva, O., Treebak, Jonas Thue, Hansen, J. B., Gerhart-Hines, Zach, Madsen, Kenneth Lindegaard & Holst, Birgitte, 2023, In: Journal of the endocrine society. 7, 6, p. 1-13 bvad057.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity
Falk, S., Petersen, Jonas Odgaard, Svendsen, C. S. A., Leguizamon, Cesar Ramon Romero, Jørgensen, Søren Heide, Krauth, Nathalie, Ludwig, M. Q., Jørgensen, Kathrine Lundø, Roostalu, U., Hjort-Gregersen, G. S., Nielsen, D. A. G., Ejdrup, Aske Lykke, Pers, Tune H, Dmytriyeva, O., Hecksher-Soerensen, J., Gether, Ulrik, Kohlmeier, Kristi Anne & Clemmensen, Christoffer, 2023, In: Cell Reports. 42, 5, 18 p., 112466.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Forteza, M. J., Berg, M., Edsfeldt, A., Sun, J., Baumgartner, R., Kareinen, I., Casagrande, F. B., Hedin, U., Zhang, S., Vuckovic, I., Dzeja, P. P., Polyzos, K. A., Gisterå, A., Trauelsen, M., Schwartz, T. W., Dib, L., Herrmann, J., Monaco, C., Matic, L., Gonçalves, I. & 1 others, , 2023, In: Cardiovascular Research. 119, 7, p. 1524-1536 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 (GLP-1)
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L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
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Aberrant intestinal microbiota in individuals with prediabetes
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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R
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