Schwartz Group

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  1. 2022
  2. Published

    Microbiome-derived ethanol in nonalcoholic fatty liver disease

    Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, Vonghia, L., Francque, S., Beuers, U., Gerdes, V. E. A., Bäckhed, F., Groen, A. K. & Nieuwdorp, M., 2022, In: Nature Medicine. 28, p. 2100-2106

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

    Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A. & Lane, J. R., 2022, In: Communications Biology . 5, 1, 10 p., 256.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action

    Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Outrunning obesity with Lac-Phe?

    Lund, Jens, Clemmensen, Christoffer & Schwartz, Thue W., 2022, In: Cell Metabolism. 34, 8, p. 1085-1087 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration

    Mikkelsen, R. B., Arora, Tulika, Trošt, K., Dmytriyeva, O., Jensen, Sune K. , Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, Thomas, van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, Siv Annegrethe, Schwartz, Thue W. & Bäckhed, F., 2022, In: iScience. 25, 12, 29 p., 105683.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1–induced satiation

    Vana, V., Lærke, M. K., Rehfeld, Jens Frederik, Arnold, M., Dmytriyeva, O., Langhans, W., Schwartz, Thue W. & Hansen, Harald S., 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 268-280

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2021
  9. Published

    A novel luminescence-based β-arrestin recruitment assay for unmodified receptors

    Pedersen, M. H., Pham, J., Mancebo, H., Inoue, A., Asher, W. B. & Javitch, J. A., 2021, In: Journal of Biological Chemistry. 296, 10 p., 100503.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

    Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykko, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, S. & 6 others, Nielsen, J., Schwartz, Thue W., Groen, A. K., Nieuwdorp, M., Backhed, F. & Gerdes, V. E. A., 2021, In: Journal of Internal Medicine. 289, 3, p. 340-354 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells

    Grunddal, Kaare Villum, Tonack, S., Egerod, Kristoffer Lihme, Thompson, J. J., Petersen, N., Engelstoft, M. S., Vagne, C., Keinse, C., Gradwohl, G., Offermanns, S. & Schwartz, Thue W., 2021, In: Molecular Metabolism. 51, 17 p., 101231.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

    Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Assays for detecting arrestin interaction with GPCRs

    Perry-Hauser, N. A., Asher, W. B., Hauge Pedersen, M. & Javitch, J. A., 2021, Biomolecular Interactions Part A. Shukla, A. K. (ed.). Academic Press, p. 43-65 23 p. (Methods in Cell Biology, Vol. 166).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  14. Published

    Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

    Baumgartner, R., Casagrande, F. B., Mikkelsen, R. B., Berg, M., Polyzos, K. A., Forteza, M. J., Arora, A., Schwartz, Thue W., Hjorth, Siv Annegrethe & Ketelhuth, D. F. J., 2021, In: Metabolites. 11, 7, 10 p., 411.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Encephalopathy-causing mutations in G beta(1) (GNB1) alter regulation of neuronal GIRK channels

    Reddy, H. P., Yakubovich, D., Keren-Raifman, T., Tabak, G., Tsemakhovich, V. A., Pedersen, M. H., Shalomov, B., Colombo, S., Goldstein, D. B., Javitch, J. A., Bera, A. K. & Dascal, N., 2021, In: iScience. 24, 9, 29 p., 103018.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

    Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, Siv Annegrethe, Schwartz, Thue W., Paulson-Berne, G., Hansson, G. K., Hedin, U. & Ketelhuth, D. F. J., 2021, In: Journal of Internal Medicine. 289, 1, p. 53-68 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

    Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

    Nielsen, A. L., Rajabi, N., Kudo, N., Jørgensen, Kathrine Lundø, Moreno Yruela, Carlos, Bæk, M., Fontenas, M., Lucidi, A., Madsen, A. S., Yoshida, M. & Olsen, Christian Adam, 2021, In: RSC Chemical Biology. 2, p. 612-626

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Microbial regulation of enteroendocrine cells

    Arora, Tulika, Vanslette, A. M., Hjorth, Siv Annegrethe & Backhed, F., 2021, In: Med. 2, 5, p. 553-570 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Molecular mechanism of ligand binding pathways and activation of the succinate receptor

    Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.

    Research output: Contribution to journal › Conference abstract in journal › Research

  22. Published

    Post-oral fat-induced satiation is mediated by endogenous CCK and GLP-1 in a fat self-administration mouse model

    Vana, V., Lærke, M. K., Kleberg, K., Mroz, P. A., Lindberg, B. L., Ekberg, J. H., Rehfeld, Jens Frederik, Schwartz, Thue W. & Hansen, Harald S., 2021, In: Physiology and Behavior. 234, 12 p., 113315.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Protective succinate-SUCNR1 metabolic stress signaling gone bad

    Winther, Sally, Trauelsen, Mette & Schwartz, Thue W., 2021, In: Cell Metabolism. 33, 7, p. 1276-1278 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist

    Grunddal, K. V., Diep, T. A., Petersen, N., Tough, I. R., Skov, Louise Julie, Liu, L., Buijink, J. A., Mende, F., Jin, C., Jepsen, Sara Lind, Sørensen, L. M. E., Achiam, Michael Patrick, Strandby, R. B., Bach, Anders, Hartmann, Bolette, Frimurer, Thomas Michael, Hjorth, Siv Annegrethe, Bouvier, M., Cox, H. & Holst, Birgitte, 2021, In: Molecular Metabolism. 49, 14 p., 101207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Using a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male Mice

    Andersen, Daniel Bjørklund, Grunddal, Kaare Villum, Pedersen, Jens, Kuhre, Rune Ehrenreich, Lund, M. L., Holst, Jens Juul & Ørskov, Cathrine, 2021, In: Endocrinology. 162, 3, bqaa246.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2020
  27. Published

    L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

    Lund, M. L., Sorrentino, G., Egerod, Kristoffer Lihme, Kroone, C., Mortensen, B., Knop, Filip Krag, Reimann, F., Gribble, F. M., Drucker, D. J., De Koning, E. J. P., Schoonjans, K., Bäckhed, F., Schwartz, Thue W. & Petersen, N., Apr 2020, In: Diabetes. 69, 4, p. 614-623 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4

    Tang, X., Fuchs, D., Tan, S., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Li, N. & Haeggstrom, J. Z., 2020, In: Journal of Thrombosis and Haemostasis. 18, 4, p. 976-984 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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