A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity. / Meijnikman, Abraham S.; Lappa, Dimitra; Herrema, Hilde; Aydin, Omrum; Krautkramer, Kimberly A.; Tremaroli, Valentina; Olofsson, Louise E.; Lundqvist, Annika; Bruin, Sjoerd; Acherman, Yair; Verheij, Joanne; Hjorth, Siv; Gerdes, Victor E.A.; Schwartz, Thue W.; Groen, Albert K.; Bäckhed, Fredrik; Nielsen, Jens; Nieuwdorp, Max.

In: iScience, Vol. 25, No. 8, 104828, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Meijnikman, AS, Lappa, D, Herrema, H, Aydin, O, Krautkramer, KA, Tremaroli, V, Olofsson, LE, Lundqvist, A, Bruin, S, Acherman, Y, Verheij, J, Hjorth, S, Gerdes, VEA, Schwartz, TW, Groen, AK, Bäckhed, F, Nielsen, J & Nieuwdorp, M 2022, 'A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity', iScience, vol. 25, no. 8, 104828. https://doi.org/10.1016/j.isci.2022.104828

APA

Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, S., Gerdes, V. E. A., Schwartz, T. W., Groen, A. K., Bäckhed, F., Nielsen, J., & Nieuwdorp, M. (2022). A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity. iScience, 25(8), [104828]. https://doi.org/10.1016/j.isci.2022.104828

Vancouver

Meijnikman AS, Lappa D, Herrema H, Aydin O, Krautkramer KA, Tremaroli V et al. A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity. iScience. 2022;25(8). 104828. https://doi.org/10.1016/j.isci.2022.104828

Author

Meijnikman, Abraham S. ; Lappa, Dimitra ; Herrema, Hilde ; Aydin, Omrum ; Krautkramer, Kimberly A. ; Tremaroli, Valentina ; Olofsson, Louise E. ; Lundqvist, Annika ; Bruin, Sjoerd ; Acherman, Yair ; Verheij, Joanne ; Hjorth, Siv ; Gerdes, Victor E.A. ; Schwartz, Thue W. ; Groen, Albert K. ; Bäckhed, Fredrik ; Nielsen, Jens ; Nieuwdorp, Max. / A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity. In: iScience. 2022 ; Vol. 25, No. 8.

Bibtex

@article{eb9e85c936c447588291fbf010dc2dba,
title = "A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity",
abstract = "Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.",
keywords = "Biological sciences, Human metabolism, Physiology, Systems biology",
author = "Meijnikman, {Abraham S.} and Dimitra Lappa and Hilde Herrema and Omrum Aydin and Krautkramer, {Kimberly A.} and Valentina Tremaroli and Olofsson, {Louise E.} and Annika Lundqvist and Sjoerd Bruin and Yair Acherman and Joanne Verheij and Siv Hjorth and Gerdes, {Victor E.A.} and Schwartz, {Thue W.} and Groen, {Albert K.} and Fredrik B{\"a}ckhed and Jens Nielsen and Max Nieuwdorp",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.isci.2022.104828",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity

AU - Meijnikman, Abraham S.

AU - Lappa, Dimitra

AU - Herrema, Hilde

AU - Aydin, Omrum

AU - Krautkramer, Kimberly A.

AU - Tremaroli, Valentina

AU - Olofsson, Louise E.

AU - Lundqvist, Annika

AU - Bruin, Sjoerd

AU - Acherman, Yair

AU - Verheij, Joanne

AU - Hjorth, Siv

AU - Gerdes, Victor E.A.

AU - Schwartz, Thue W.

AU - Groen, Albert K.

AU - Bäckhed, Fredrik

AU - Nielsen, Jens

AU - Nieuwdorp, Max

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.

AB - Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.

KW - Biological sciences

KW - Human metabolism

KW - Physiology

KW - Systems biology

U2 - 10.1016/j.isci.2022.104828

DO - 10.1016/j.isci.2022.104828

M3 - Journal article

C2 - 35992074

AN - SCOPUS:85135716317

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 8

M1 - 104828

ER -

ID: 316886250