Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids

Research output: Contribution to journal › Review › Research › peer-review

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Metabolite G-protein coupled receptor signaling : Potential regulation of eicosanoids. / Tang, Xiao; Hou, Yaolin; Schwartz, Thue W.; Haeggström, Jesper Z.

In: Biochemical Pharmacology, Vol. 204, 115208, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Tang, X, Hou, Y, Schwartz, TW & Haeggström, JZ 2022, 'Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids', Biochemical Pharmacology, vol. 204, 115208. https://doi.org/10.1016/j.bcp.2022.115208

APA

Tang, X., Hou, Y., Schwartz, T. W., & Haeggström, J. Z. (2022). Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids. Biochemical Pharmacology, 204, [115208]. https://doi.org/10.1016/j.bcp.2022.115208

Vancouver

Tang X, Hou Y, Schwartz TW, Haeggström JZ. Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids. Biochemical Pharmacology. 2022;204. 115208. https://doi.org/10.1016/j.bcp.2022.115208

Author

Tang, Xiao ; Hou, Yaolin ; Schwartz, Thue W. ; Haeggström, Jesper Z. / Metabolite G-protein coupled receptor signaling : Potential regulation of eicosanoids. In: Biochemical Pharmacology. 2022 ; Vol. 204.

Bibtex

@article{b0e5f24fcb7e4f279d077e8c0950328b,
title = "Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids",
abstract = "Eicosanoids are a family of bioactive compounds derived from arachidonic acid (AA) that play pivotal roles in physiology and disease, including inflammatory conditions of multiple organ systems. The biosynthesis of eicosanoids requires a series of catalytic steps that are controlled by designated enzymes, which can be regulated by inflammatory and stress signals via transcriptional and translational mechanisms. In the past decades, evidence have emerged indicating that G-protein coupled receptors (GPCRs) can sense extracellular metabolites, and regulate inflammatory responses including eicosanoid production. This review focuses on the recent advances of metabolite GPCRs research, their role in regulation of eicosanoid biosynthesis, and the link to pathophysiological conditions.",
keywords = "Eicosanoid, GPCR, Immunometabolism, Inflammation, Metabolic stress, Metabolite",
author = "Xiao Tang and Yaolin Hou and Schwartz, {Thue W.} and Haeggstr{\"o}m, {Jesper Z.}",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2022",
doi = "10.1016/j.bcp.2022.115208",
language = "English",
volume = "204",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Metabolite G-protein coupled receptor signaling

T2 - Potential regulation of eicosanoids

AU - Tang, Xiao

AU - Hou, Yaolin

AU - Schwartz, Thue W.

AU - Haeggström, Jesper Z.

N1 - Publisher Copyright: © 2022

PY - 2022

Y1 - 2022

N2 - Eicosanoids are a family of bioactive compounds derived from arachidonic acid (AA) that play pivotal roles in physiology and disease, including inflammatory conditions of multiple organ systems. The biosynthesis of eicosanoids requires a series of catalytic steps that are controlled by designated enzymes, which can be regulated by inflammatory and stress signals via transcriptional and translational mechanisms. In the past decades, evidence have emerged indicating that G-protein coupled receptors (GPCRs) can sense extracellular metabolites, and regulate inflammatory responses including eicosanoid production. This review focuses on the recent advances of metabolite GPCRs research, their role in regulation of eicosanoid biosynthesis, and the link to pathophysiological conditions.

AB - Eicosanoids are a family of bioactive compounds derived from arachidonic acid (AA) that play pivotal roles in physiology and disease, including inflammatory conditions of multiple organ systems. The biosynthesis of eicosanoids requires a series of catalytic steps that are controlled by designated enzymes, which can be regulated by inflammatory and stress signals via transcriptional and translational mechanisms. In the past decades, evidence have emerged indicating that G-protein coupled receptors (GPCRs) can sense extracellular metabolites, and regulate inflammatory responses including eicosanoid production. This review focuses on the recent advances of metabolite GPCRs research, their role in regulation of eicosanoid biosynthesis, and the link to pathophysiological conditions.

KW - Eicosanoid

KW - GPCR

KW - Immunometabolism

KW - Inflammation

KW - Metabolic stress

KW - Metabolite

U2 - 10.1016/j.bcp.2022.115208

DO - 10.1016/j.bcp.2022.115208

M3 - Review

C2 - 35963340

AN - SCOPUS:85135949264

VL - 204

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

M1 - 115208

ER -

ID: 318038700