snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. / Sun, Wenfei; Dong, Hua; Balaz, Miroslav; Slyper, Michal; Drokhlyansky, Eugene; Colleluori, Georgia; Giordano, Antonio; Kovanicova, Zuzana; Stefanicka, Patrik; Balazova, Lucia; Ding, Lianggong; Husted, Anna Sofie; Rudofsky, Gottfried; Ukropec, Jozef; Cinti, Saverio; Schwartz, Thue W.; Regev, Aviv; Wolfrum, Christian.

In: Nature, Vol. 587, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sun, W, Dong, H, Balaz, M, Slyper, M, Drokhlyansky, E, Colleluori, G, Giordano, A, Kovanicova, Z, Stefanicka, P, Balazova, L, Ding, L, Husted, AS, Rudofsky, G, Ukropec, J, Cinti, S, Schwartz, TW, Regev, A & Wolfrum, C 2020, 'snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis', Nature, vol. 587. https://doi.org/10.1038/s41586-020-2856-x

APA

Sun, W., Dong, H., Balaz, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovanicova, Z., Stefanicka, P., Balazova, L., Ding, L., Husted, A. S., Rudofsky, G., Ukropec, J., Cinti, S., Schwartz, T. W., Regev, A., & Wolfrum, C. (2020). snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature, 587. https://doi.org/10.1038/s41586-020-2856-x

Vancouver

Sun W, Dong H, Balaz M, Slyper M, Drokhlyansky E, Colleluori G et al. snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature. 2020;587. https://doi.org/10.1038/s41586-020-2856-x

Author

Sun, Wenfei ; Dong, Hua ; Balaz, Miroslav ; Slyper, Michal ; Drokhlyansky, Eugene ; Colleluori, Georgia ; Giordano, Antonio ; Kovanicova, Zuzana ; Stefanicka, Patrik ; Balazova, Lucia ; Ding, Lianggong ; Husted, Anna Sofie ; Rudofsky, Gottfried ; Ukropec, Jozef ; Cinti, Saverio ; Schwartz, Thue W. ; Regev, Aviv ; Wolfrum, Christian. / snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. In: Nature. 2020 ; Vol. 587.

Bibtex

@article{3bd9fc8f3a1441b7aa7887603eb3c15c,
title = "snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis",
abstract = "Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite)(1). It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications(2,3). In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals(4). Here we use single-nucleus RNA-sequencing (snRNA-seq) analysis in mice and humans to characterize adipocyte heterogeneity. We identify a rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures, and we show that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity. Human adipose tissue contains higher numbers of cells of this subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway could be used to restore thermogenic activity.",
keywords = "NUCLEUS RNA-SEQ, ADIPOSE-TISSUE, DEHYDROGENASE 1, RETINOIC ACID, BROWN, WHITE, CELL, PROTEIN, MOUSE, BRITE",
author = "Wenfei Sun and Hua Dong and Miroslav Balaz and Michal Slyper and Eugene Drokhlyansky and Georgia Colleluori and Antonio Giordano and Zuzana Kovanicova and Patrik Stefanicka and Lucia Balazova and Lianggong Ding and Husted, {Anna Sofie} and Gottfried Rudofsky and Jozef Ukropec and Saverio Cinti and Schwartz, {Thue W.} and Aviv Regev and Christian Wolfrum",
year = "2020",
doi = "10.1038/s41586-020-2856-x",
language = "English",
volume = "587",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

AU - Sun, Wenfei

AU - Dong, Hua

AU - Balaz, Miroslav

AU - Slyper, Michal

AU - Drokhlyansky, Eugene

AU - Colleluori, Georgia

AU - Giordano, Antonio

AU - Kovanicova, Zuzana

AU - Stefanicka, Patrik

AU - Balazova, Lucia

AU - Ding, Lianggong

AU - Husted, Anna Sofie

AU - Rudofsky, Gottfried

AU - Ukropec, Jozef

AU - Cinti, Saverio

AU - Schwartz, Thue W.

AU - Regev, Aviv

AU - Wolfrum, Christian

PY - 2020

Y1 - 2020

N2 - Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite)(1). It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications(2,3). In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals(4). Here we use single-nucleus RNA-sequencing (snRNA-seq) analysis in mice and humans to characterize adipocyte heterogeneity. We identify a rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures, and we show that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity. Human adipose tissue contains higher numbers of cells of this subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway could be used to restore thermogenic activity.

AB - Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite)(1). It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications(2,3). In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals(4). Here we use single-nucleus RNA-sequencing (snRNA-seq) analysis in mice and humans to characterize adipocyte heterogeneity. We identify a rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures, and we show that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity. Human adipose tissue contains higher numbers of cells of this subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway could be used to restore thermogenic activity.

KW - NUCLEUS RNA-SEQ

KW - ADIPOSE-TISSUE

KW - DEHYDROGENASE 1

KW - RETINOIC ACID

KW - BROWN

KW - WHITE

KW - CELL

KW - PROTEIN

KW - MOUSE

KW - BRITE

U2 - 10.1038/s41586-020-2856-x

DO - 10.1038/s41586-020-2856-x

M3 - Journal article

C2 - 33116305

VL - 587

JO - Nature

JF - Nature

SN - 0028-0836

ER -

ID: 251251673