Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
Research output: Contribution to journal › Journal article › Research › peer-review
By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
Original language | English |
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Journal | F E B S Letters |
Volume | 211 |
Issue number | 2 |
Pages (from-to) | 169-74 |
Number of pages | 6 |
ISSN | 0014-5793 |
Publication status | Published - 1987 |
- Animals, Glucagon, Ileum, Insulin, Intestinal Mucosa, Peptides, Swine
Research areas
ID: 44293803