Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. / Sanchez, Clara; Colson, Cécilia; Gautier, Nadine; Noser, Pascal; Salvi, Juliette; Villet, Maxime; Fleuriot, Lucile; Peltier, Caroline; Schlich, Pascal; Brau, Frédéric; Sharif, Ariane; Altintas, Ali; Amri, Ez Zoubir; Nahon, Jean Louis; Blondeau, Nicolas; Benani, Alexandre; Barrès, Romain; Rovère, Carole.

In: Brain, Behavior, and Immunity, Vol. 117, 2024, p. 330-346.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sanchez, C, Colson, C, Gautier, N, Noser, P, Salvi, J, Villet, M, Fleuriot, L, Peltier, C, Schlich, P, Brau, F, Sharif, A, Altintas, A, Amri, EZ, Nahon, JL, Blondeau, N, Benani, A, Barrès, R & Rovère, C 2024, 'Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity', Brain, Behavior, and Immunity, vol. 117, pp. 330-346. https://doi.org/10.1016/j.bbi.2024.01.216

APA

Sanchez, C., Colson, C., Gautier, N., Noser, P., Salvi, J., Villet, M., Fleuriot, L., Peltier, C., Schlich, P., Brau, F., Sharif, A., Altintas, A., Amri, E. Z., Nahon, J. L., Blondeau, N., Benani, A., Barrès, R., & Rovère, C. (2024). Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Brain, Behavior, and Immunity, 117, 330-346. https://doi.org/10.1016/j.bbi.2024.01.216

Vancouver

Sanchez C, Colson C, Gautier N, Noser P, Salvi J, Villet M et al. Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Brain, Behavior, and Immunity. 2024;117:330-346. https://doi.org/10.1016/j.bbi.2024.01.216

Author

Sanchez, Clara ; Colson, Cécilia ; Gautier, Nadine ; Noser, Pascal ; Salvi, Juliette ; Villet, Maxime ; Fleuriot, Lucile ; Peltier, Caroline ; Schlich, Pascal ; Brau, Frédéric ; Sharif, Ariane ; Altintas, Ali ; Amri, Ez Zoubir ; Nahon, Jean Louis ; Blondeau, Nicolas ; Benani, Alexandre ; Barrès, Romain ; Rovère, Carole. / Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. In: Brain, Behavior, and Immunity. 2024 ; Vol. 117. pp. 330-346.

Bibtex

@article{a808a4d0a53949f8a9d28b8577f32db3,
title = "Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity",
abstract = "Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.",
keywords = "Anxiety, Cognitive disorders, High fat diet, Hippocampus, Hypothalamus, Memory, Neuroinflammation, Obesity, Polyunsaturated fatty acids, ω6/ω3",
author = "Clara Sanchez and C{\'e}cilia Colson and Nadine Gautier and Pascal Noser and Juliette Salvi and Maxime Villet and Lucile Fleuriot and Caroline Peltier and Pascal Schlich and Fr{\'e}d{\'e}ric Brau and Ariane Sharif and Ali Altintas and Amri, {Ez Zoubir} and Nahon, {Jean Louis} and Nicolas Blondeau and Alexandre Benani and Romain Barr{\`e}s and Carole Rov{\`e}re",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",
year = "2024",
doi = "10.1016/j.bbi.2024.01.216",
language = "English",
volume = "117",
pages = "330--346",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity

AU - Sanchez, Clara

AU - Colson, Cécilia

AU - Gautier, Nadine

AU - Noser, Pascal

AU - Salvi, Juliette

AU - Villet, Maxime

AU - Fleuriot, Lucile

AU - Peltier, Caroline

AU - Schlich, Pascal

AU - Brau, Frédéric

AU - Sharif, Ariane

AU - Altintas, Ali

AU - Amri, Ez Zoubir

AU - Nahon, Jean Louis

AU - Blondeau, Nicolas

AU - Benani, Alexandre

AU - Barrès, Romain

AU - Rovère, Carole

N1 - Publisher Copyright: © 2024 The Author(s)

PY - 2024

Y1 - 2024

N2 - Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.

AB - Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared to other HFD groups. Both HFD-ME and HFD-HI impaired glucose metabolism while HFD-LO partly prevented insulin intolerance and was associated with normal leptin levels despite higher subcutaneous and perigonadal adiposity. Only HFD-HI increased anxiety and impaired spatial memory, together with increased inflammation in the hypothalamus and hippocampus. Our results show that impaired glucose metabolism and neuroinflammation are uncoupled, and support that diets with a high ω6/ω3 ratio are associated with neuroinflammation and the behavioral deterioration coupled with the consumption of diets rich in fat.

KW - Anxiety

KW - Cognitive disorders

KW - High fat diet

KW - Hippocampus

KW - Hypothalamus

KW - Memory

KW - Neuroinflammation

KW - Obesity

KW - Polyunsaturated fatty acids

KW - ω6/ω3

U2 - 10.1016/j.bbi.2024.01.216

DO - 10.1016/j.bbi.2024.01.216

M3 - Journal article

C2 - 38309640

AN - SCOPUS:85184475799

VL - 117

SP - 330

EP - 346

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -

ID: 385711213