Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M

Research output: Contribution to journal › Journal article › Research › peer-review

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Exercise-induced crosstalk between immune cells and adipocytes in humans : Role of oncostatin-M. / Dollet, Lucile; Lundell, Leonidas S.; Chibalin, Alexander V.; Pendergrast, Logan A.; Pillon, Nicolas J.; Lansbury, Elizabeth L.; Elmastas, Merve; Frendo-Cumbo, Scott; Jalkanen, Jutta; de Castro Barbosa, Thais; Cervone, Daniel T.; Caidahl, Kenneth; Dmytriyeva, Oksana; Deshmukh, Atul S.; Barrès, Romain; Rydén, Mikael; Wallberg-Henriksson, Harriet; Zierath, Juleen R.; Krook, Anna.

In: Cell Reports Medicine, Vol. 5, No. 1, 101348, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dollet, L, Lundell, LS, Chibalin, AV, Pendergrast, LA, Pillon, NJ, Lansbury, EL, Elmastas, M, Frendo-Cumbo, S, Jalkanen, J, de Castro Barbosa, T, Cervone, DT, Caidahl, K, Dmytriyeva, O, Deshmukh, AS, Barrès, R, Rydén, M, Wallberg-Henriksson, H, Zierath, JR & Krook, A 2024, 'Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M', Cell Reports Medicine, vol. 5, no. 1, 101348. https://doi.org/10.1016/j.xcrm.2023.101348

APA

Dollet, L., Lundell, L. S., Chibalin, A. V., Pendergrast, L. A., Pillon, N. J., Lansbury, E. L., Elmastas, M., Frendo-Cumbo, S., Jalkanen, J., de Castro Barbosa, T., Cervone, D. T., Caidahl, K., Dmytriyeva, O., Deshmukh, A. S., Barrès, R., Rydén, M., Wallberg-Henriksson, H., Zierath, J. R., & Krook, A. (2024). Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M. Cell Reports Medicine, 5(1), [101348]. https://doi.org/10.1016/j.xcrm.2023.101348

Vancouver

Dollet L, Lundell LS, Chibalin AV, Pendergrast LA, Pillon NJ, Lansbury EL et al. Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M. Cell Reports Medicine. 2024;5(1). 101348. https://doi.org/10.1016/j.xcrm.2023.101348

Author

Dollet, Lucile ; Lundell, Leonidas S. ; Chibalin, Alexander V. ; Pendergrast, Logan A. ; Pillon, Nicolas J. ; Lansbury, Elizabeth L. ; Elmastas, Merve ; Frendo-Cumbo, Scott ; Jalkanen, Jutta ; de Castro Barbosa, Thais ; Cervone, Daniel T. ; Caidahl, Kenneth ; Dmytriyeva, Oksana ; Deshmukh, Atul S. ; Barrès, Romain ; Rydén, Mikael ; Wallberg-Henriksson, Harriet ; Zierath, Juleen R. ; Krook, Anna. / Exercise-induced crosstalk between immune cells and adipocytes in humans : Role of oncostatin-M. In: Cell Reports Medicine. 2024 ; Vol. 5, No. 1.

Bibtex

@article{5b1ba19a8a2e4e8cad8bec9176104616,
title = "Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M",
abstract = "The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk, especially between skeletal muscle and adipose tissue, and the role in mediating beneficial effects of exercise. We studied the adipose tissue transcriptome in men and women with normal glucose tolerance or type 2 diabetes following an acute exercise bout, revealing substantial exercise- and time-dependent changes, with sustained increase in inflammatory genes in type 2 diabetes. We identify oncostatin-M as one of the most upregulated adipose-tissue-secreted factors post-exercise. In cultured human adipocytes, oncostatin-M enhances MAPK signaling and regulates lipolysis. Oncostatin-M expression arises predominantly from adipose tissue immune cell fractions, while the corresponding receptors are expressed in adipocytes. Oncostatin-M expression increases in cultured human Thp1 macrophages following exercise-like stimuli. Our results suggest that immune cells, via secreted factors such as oncostatin-M, mediate a crosstalk between skeletal muscle and adipose tissue during exercise to regulate adipocyte metabolism and adaptation.",
keywords = "adipose tissue, crosstalk, exercise, human, immune cells, inflammation, oncostatin-M, skeletal muscle, type 2 diabetes",
author = "Lucile Dollet and Lundell, {Leonidas S.} and Chibalin, {Alexander V.} and Pendergrast, {Logan A.} and Pillon, {Nicolas J.} and Lansbury, {Elizabeth L.} and Merve Elmastas and Scott Frendo-Cumbo and Jutta Jalkanen and {de Castro Barbosa}, Thais and Cervone, {Daniel T.} and Kenneth Caidahl and Oksana Dmytriyeva and Deshmukh, {Atul S.} and Romain Barr{\`e}s and Mikael Ryd{\'e}n and Harriet Wallberg-Henriksson and Zierath, {Juleen R.} and Anna Krook",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors",
year = "2024",
doi = "10.1016/j.xcrm.2023.101348",
language = "English",
volume = "5",
journal = "Cell Reports Medicine",
issn = "2666-3791",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Exercise-induced crosstalk between immune cells and adipocytes in humans

T2 - Role of oncostatin-M

AU - Dollet, Lucile

AU - Lundell, Leonidas S.

AU - Chibalin, Alexander V.

AU - Pendergrast, Logan A.

AU - Pillon, Nicolas J.

AU - Lansbury, Elizabeth L.

AU - Elmastas, Merve

AU - Frendo-Cumbo, Scott

AU - Jalkanen, Jutta

AU - de Castro Barbosa, Thais

AU - Cervone, Daniel T.

AU - Caidahl, Kenneth

AU - Dmytriyeva, Oksana

AU - Deshmukh, Atul S.

AU - Barrès, Romain

AU - Rydén, Mikael

AU - Wallberg-Henriksson, Harriet

AU - Zierath, Juleen R.

AU - Krook, Anna

N1 - Publisher Copyright: © 2024 The Authors

PY - 2024

Y1 - 2024

N2 - The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk, especially between skeletal muscle and adipose tissue, and the role in mediating beneficial effects of exercise. We studied the adipose tissue transcriptome in men and women with normal glucose tolerance or type 2 diabetes following an acute exercise bout, revealing substantial exercise- and time-dependent changes, with sustained increase in inflammatory genes in type 2 diabetes. We identify oncostatin-M as one of the most upregulated adipose-tissue-secreted factors post-exercise. In cultured human adipocytes, oncostatin-M enhances MAPK signaling and regulates lipolysis. Oncostatin-M expression arises predominantly from adipose tissue immune cell fractions, while the corresponding receptors are expressed in adipocytes. Oncostatin-M expression increases in cultured human Thp1 macrophages following exercise-like stimuli. Our results suggest that immune cells, via secreted factors such as oncostatin-M, mediate a crosstalk between skeletal muscle and adipose tissue during exercise to regulate adipocyte metabolism and adaptation.

AB - The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk, especially between skeletal muscle and adipose tissue, and the role in mediating beneficial effects of exercise. We studied the adipose tissue transcriptome in men and women with normal glucose tolerance or type 2 diabetes following an acute exercise bout, revealing substantial exercise- and time-dependent changes, with sustained increase in inflammatory genes in type 2 diabetes. We identify oncostatin-M as one of the most upregulated adipose-tissue-secreted factors post-exercise. In cultured human adipocytes, oncostatin-M enhances MAPK signaling and regulates lipolysis. Oncostatin-M expression arises predominantly from adipose tissue immune cell fractions, while the corresponding receptors are expressed in adipocytes. Oncostatin-M expression increases in cultured human Thp1 macrophages following exercise-like stimuli. Our results suggest that immune cells, via secreted factors such as oncostatin-M, mediate a crosstalk between skeletal muscle and adipose tissue during exercise to regulate adipocyte metabolism and adaptation.

KW - adipose tissue

KW - crosstalk

KW - exercise

KW - human

KW - immune cells

KW - inflammation

KW - oncostatin-M

KW - skeletal muscle

KW - type 2 diabetes

U2 - 10.1016/j.xcrm.2023.101348

DO - 10.1016/j.xcrm.2023.101348

M3 - Journal article

C2 - 38151020

AN - SCOPUS:85182347436

VL - 5

JO - Cell Reports Medicine

JF - Cell Reports Medicine

SN - 2666-3791

IS - 1

M1 - 101348

ER -

ID: 386599234