Seasonal light hours modulate peripheral clocks and energy metabolism in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Seasonal light hours modulate peripheral clocks and energy metabolism in mice. / Small, Lewin; Lundell, Leonidas S.; Iversen, Jo; Ehrlich, Amy M.; Dall, Morten; Basse, Astrid L.; Dalbram, Emilie; Hansen, Ann N.; Treebak, Jonas T.; Barrès, Romain; Zierath, Juleen R.

In: Cell Metabolism, Vol. 35, No. 10, 2023, p. 1722-1735.e5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Small, L, Lundell, LS, Iversen, J, Ehrlich, AM, Dall, M, Basse, AL, Dalbram, E, Hansen, AN, Treebak, JT, Barrès, R & Zierath, JR 2023, 'Seasonal light hours modulate peripheral clocks and energy metabolism in mice', Cell Metabolism, vol. 35, no. 10, pp. 1722-1735.e5. https://doi.org/10.1016/j.cmet.2023.08.005

APA

Small, L., Lundell, L. S., Iversen, J., Ehrlich, A. M., Dall, M., Basse, A. L., Dalbram, E., Hansen, A. N., Treebak, J. T., Barrès, R., & Zierath, J. R. (2023). Seasonal light hours modulate peripheral clocks and energy metabolism in mice. Cell Metabolism, 35(10), 1722-1735.e5. https://doi.org/10.1016/j.cmet.2023.08.005

Vancouver

Small L, Lundell LS, Iversen J, Ehrlich AM, Dall M, Basse AL et al. Seasonal light hours modulate peripheral clocks and energy metabolism in mice. Cell Metabolism. 2023;35(10):1722-1735.e5. https://doi.org/10.1016/j.cmet.2023.08.005

Author

Small, Lewin ; Lundell, Leonidas S. ; Iversen, Jo ; Ehrlich, Amy M. ; Dall, Morten ; Basse, Astrid L. ; Dalbram, Emilie ; Hansen, Ann N. ; Treebak, Jonas T. ; Barrès, Romain ; Zierath, Juleen R. / Seasonal light hours modulate peripheral clocks and energy metabolism in mice. In: Cell Metabolism. 2023 ; Vol. 35, No. 10. pp. 1722-1735.e5.

Bibtex

@article{034acd4c74c9486a8782734300c42635,
title = "Seasonal light hours modulate peripheral clocks and energy metabolism in mice",
abstract = "Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h light:12 h dark photoperiod corresponding to the light duration at the equator. We hypothesized that altering the seasonal photoperiod affects both the rhythmicity of peripheral tissue clocks and energy homeostasis. Mice were housed at photoperiods representing either light hours in summer, winter, or the equinox. Mice housed at a winter photoperiod exhibited an increase in the amplitude of rhythmic lipid metabolism and a modest reduction in fat mass and liver triglyceride content. Comparing melatonin-proficient and -deficient mice, the effect of seasonal light on energy metabolism was largely driven by differences in the rhythmicity of food intake and not melatonin. Together, these data indicate that seasonal light impacts energy metabolism by modulating the timing of eating.",
keywords = "circadian biology, energy homeostasis, glucose metabolism, hormones, integrative physiology, obesity, transcriptomics",
author = "Lewin Small and Lundell, {Leonidas S.} and Jo Iversen and Ehrlich, {Amy M.} and Morten Dall and Basse, {Astrid L.} and Emilie Dalbram and Hansen, {Ann N.} and Treebak, {Jonas T.} and Romain Barr{\`e}s and Zierath, {Juleen R.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.cmet.2023.08.005",
language = "English",
volume = "35",
pages = "1722--1735.e5",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "10",

}

RIS

TY - JOUR

T1 - Seasonal light hours modulate peripheral clocks and energy metabolism in mice

AU - Small, Lewin

AU - Lundell, Leonidas S.

AU - Iversen, Jo

AU - Ehrlich, Amy M.

AU - Dall, Morten

AU - Basse, Astrid L.

AU - Dalbram, Emilie

AU - Hansen, Ann N.

AU - Treebak, Jonas T.

AU - Barrès, Romain

AU - Zierath, Juleen R.

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h light:12 h dark photoperiod corresponding to the light duration at the equator. We hypothesized that altering the seasonal photoperiod affects both the rhythmicity of peripheral tissue clocks and energy homeostasis. Mice were housed at photoperiods representing either light hours in summer, winter, or the equinox. Mice housed at a winter photoperiod exhibited an increase in the amplitude of rhythmic lipid metabolism and a modest reduction in fat mass and liver triglyceride content. Comparing melatonin-proficient and -deficient mice, the effect of seasonal light on energy metabolism was largely driven by differences in the rhythmicity of food intake and not melatonin. Together, these data indicate that seasonal light impacts energy metabolism by modulating the timing of eating.

AB - Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h light:12 h dark photoperiod corresponding to the light duration at the equator. We hypothesized that altering the seasonal photoperiod affects both the rhythmicity of peripheral tissue clocks and energy homeostasis. Mice were housed at photoperiods representing either light hours in summer, winter, or the equinox. Mice housed at a winter photoperiod exhibited an increase in the amplitude of rhythmic lipid metabolism and a modest reduction in fat mass and liver triglyceride content. Comparing melatonin-proficient and -deficient mice, the effect of seasonal light on energy metabolism was largely driven by differences in the rhythmicity of food intake and not melatonin. Together, these data indicate that seasonal light impacts energy metabolism by modulating the timing of eating.

KW - circadian biology

KW - energy homeostasis

KW - glucose metabolism

KW - hormones

KW - integrative physiology

KW - obesity

KW - transcriptomics

U2 - 10.1016/j.cmet.2023.08.005

DO - 10.1016/j.cmet.2023.08.005

M3 - Journal article

C2 - 37689069

AN - SCOPUS:85173590530

VL - 35

SP - 1722-1735.e5

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 10

ER -

ID: 371655598