Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development

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Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development. / Altıntaş, Ali; Laker, Rhianna C; Garde, Christian; Barrès, Romain; Zierath, Juleen R.

In: Epigenomics, Vol. 12, No. 8, 2020, p. 701-713.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Altıntaş, A, Laker, RC, Garde, C, Barrès, R & Zierath, JR 2020, 'Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development', Epigenomics, vol. 12, no. 8, pp. 701-713. https://doi.org/10.2217/epi-2019-0391

APA

Altıntaş, A., Laker, R. C., Garde, C., Barrès, R., & Zierath, J. R. (2020). Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development. Epigenomics, 12(8), 701-713. https://doi.org/10.2217/epi-2019-0391

Vancouver

Altıntaş A, Laker RC, Garde C, Barrès R, Zierath JR. Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development. Epigenomics. 2020;12(8):701-713. https://doi.org/10.2217/epi-2019-0391

Author

Altıntaş, Ali ; Laker, Rhianna C ; Garde, Christian ; Barrès, Romain ; Zierath, Juleen R. / Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development. In: Epigenomics. 2020 ; Vol. 12, No. 8. pp. 701-713.

Bibtex

@article{2cca3109840c4fdda979bd8fcfbdc1af,
title = "Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development",
abstract = "Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal muscle, a major insulin-sensitive tissue responsible for glucose homeostasis. We determined whether transcriptional oscillations are associated with CpG methylation changes in skeletal muscle. Materials & methods: We performed rhythmicity analysis on the transcriptome and CpG methylome of circadian synchronized myotubes. Results: We identified several transcripts and CpG-sites displaying oscillatory behavior, which were enriched with GO terms related to metabolism and development. Oscillating CpG methylation was associated with rhythmic expression of 31 transcripts. Conclusion: Although circadian oscillations may be regulated by rhythmic DNA methylation, strong rhythmic associations between transcriptome and CpG methylation were not identified. This resource constitutes a transcriptomic/epigenomic atlas of skeletal muscle and regulation of circadian rhythms.",
author = "Ali Altınta{\c s} and Laker, {Rhianna C} and Christian Garde and Romain Barr{\`e}s and Zierath, {Juleen R}",
year = "2020",
doi = "10.2217/epi-2019-0391",
language = "English",
volume = "12",
pages = "701--713",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development

AU - Altıntaş, Ali

AU - Laker, Rhianna C

AU - Garde, Christian

AU - Barrès, Romain

AU - Zierath, Juleen R

PY - 2020

Y1 - 2020

N2 - Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal muscle, a major insulin-sensitive tissue responsible for glucose homeostasis. We determined whether transcriptional oscillations are associated with CpG methylation changes in skeletal muscle. Materials & methods: We performed rhythmicity analysis on the transcriptome and CpG methylome of circadian synchronized myotubes. Results: We identified several transcripts and CpG-sites displaying oscillatory behavior, which were enriched with GO terms related to metabolism and development. Oscillating CpG methylation was associated with rhythmic expression of 31 transcripts. Conclusion: Although circadian oscillations may be regulated by rhythmic DNA methylation, strong rhythmic associations between transcriptome and CpG methylation were not identified. This resource constitutes a transcriptomic/epigenomic atlas of skeletal muscle and regulation of circadian rhythms.

AB - Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal muscle, a major insulin-sensitive tissue responsible for glucose homeostasis. We determined whether transcriptional oscillations are associated with CpG methylation changes in skeletal muscle. Materials & methods: We performed rhythmicity analysis on the transcriptome and CpG methylome of circadian synchronized myotubes. Results: We identified several transcripts and CpG-sites displaying oscillatory behavior, which were enriched with GO terms related to metabolism and development. Oscillating CpG methylation was associated with rhythmic expression of 31 transcripts. Conclusion: Although circadian oscillations may be regulated by rhythmic DNA methylation, strong rhythmic associations between transcriptome and CpG methylation were not identified. This resource constitutes a transcriptomic/epigenomic atlas of skeletal muscle and regulation of circadian rhythms.

U2 - 10.2217/epi-2019-0391

DO - 10.2217/epi-2019-0391

M3 - Journal article

C2 - 32157909

VL - 12

SP - 701

EP - 713

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 8

ER -

ID: 237651915