Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise

Research output: Contribution to journal › Review › Research › peer-review

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Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise. / Dent, Jessica R.; Stocks, Ben; Campelj, Dean G.; Philp, Andrew.

In: Seminars in Cell and Developmental Biology, Vol. 143, 2023, p. 3-16.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Dent, JR, Stocks, B, Campelj, DG & Philp, A 2023, 'Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise', Seminars in Cell and Developmental Biology, vol. 143, pp. 3-16. https://doi.org/10.1016/j.semcdb.2022.03.022

APA

Dent, J. R., Stocks, B., Campelj, D. G., & Philp, A. (2023). Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise. Seminars in Cell and Developmental Biology, 143, 3-16. https://doi.org/10.1016/j.semcdb.2022.03.022

Vancouver

Dent JR, Stocks B, Campelj DG, Philp A. Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise. Seminars in Cell and Developmental Biology. 2023;143:3-16. https://doi.org/10.1016/j.semcdb.2022.03.022

Author

Dent, Jessica R. ; Stocks, Ben ; Campelj, Dean G. ; Philp, Andrew. / Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise. In: Seminars in Cell and Developmental Biology. 2023 ; Vol. 143. pp. 3-16.

Bibtex

@article{4bc4c2cb49b247a79f5b89a7e1fc4dfc,
title = "Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise",
abstract = "Endurance exercise is well established to increase mitochondrial content and function in skeletal muscle, a process termed mitochondrial biogenesis. Current understanding is that exercise initiates skeletal muscle mitochondrial remodeling via modulation of cellular nutrient, energetic and contractile stress pathways. These subtle changes in the cellular milieu are sensed by numerous transduction pathways that serve to initiate and coordinate an increase in mitochondrial gene transcription and translation. The result of these acute signaling events is the promotion of growth and assembly of mitochondria, coupled to a greater capacity for aerobic ATP provision in skeletal muscle. The aim of this review is to highlight the acute metabolic events induced by endurance exercise and the subsequent molecular pathways that sense this transient change in cellular homeostasis to drive mitochondrial adaptation and remodeling.",
keywords = "Adaptation, Exercise, Metabolism, Mitochondria",
author = "Dent, {Jessica R.} and Ben Stocks and Campelj, {Dean G.} and Andrew Philp",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2023",
doi = "10.1016/j.semcdb.2022.03.022",
language = "English",
volume = "143",
pages = "3--16",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise

AU - Dent, Jessica R.

AU - Stocks, Ben

AU - Campelj, Dean G.

AU - Philp, Andrew

N1 - Publisher Copyright: © 2022

PY - 2023

Y1 - 2023

N2 - Endurance exercise is well established to increase mitochondrial content and function in skeletal muscle, a process termed mitochondrial biogenesis. Current understanding is that exercise initiates skeletal muscle mitochondrial remodeling via modulation of cellular nutrient, energetic and contractile stress pathways. These subtle changes in the cellular milieu are sensed by numerous transduction pathways that serve to initiate and coordinate an increase in mitochondrial gene transcription and translation. The result of these acute signaling events is the promotion of growth and assembly of mitochondria, coupled to a greater capacity for aerobic ATP provision in skeletal muscle. The aim of this review is to highlight the acute metabolic events induced by endurance exercise and the subsequent molecular pathways that sense this transient change in cellular homeostasis to drive mitochondrial adaptation and remodeling.

AB - Endurance exercise is well established to increase mitochondrial content and function in skeletal muscle, a process termed mitochondrial biogenesis. Current understanding is that exercise initiates skeletal muscle mitochondrial remodeling via modulation of cellular nutrient, energetic and contractile stress pathways. These subtle changes in the cellular milieu are sensed by numerous transduction pathways that serve to initiate and coordinate an increase in mitochondrial gene transcription and translation. The result of these acute signaling events is the promotion of growth and assembly of mitochondria, coupled to a greater capacity for aerobic ATP provision in skeletal muscle. The aim of this review is to highlight the acute metabolic events induced by endurance exercise and the subsequent molecular pathways that sense this transient change in cellular homeostasis to drive mitochondrial adaptation and remodeling.

KW - Adaptation

KW - Exercise

KW - Metabolism

KW - Mitochondria

U2 - 10.1016/j.semcdb.2022.03.022

DO - 10.1016/j.semcdb.2022.03.022

M3 - Review

C2 - 35351374

AN - SCOPUS:85127323712

VL - 143

SP - 3

EP - 16

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -

ID: 305689097