Gerhart-Hines Group

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  1. Published

    Lipolysis regulates major transcriptional programs in brown adipocytes

    Markussen, L. K., Rondini, E. A., Johansen, O. S., Madsen, J. G. S., Sustarsic, E. G., Marcher, A. B., Hansen, Jacob B., Gerhart-Hines, Zach, Granneman, J. G. & Mandrup, S., 2022, In: Nature Communications. 13, 1, 16 p., 3956.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    No effect of dietary fish oil supplementation on the recruitment of brown and brite adipocytes in mice or humans under thermoneutral conditions

    Maurer, S. F., Dieckmann, S., Lund, Jens, Fromme, T., Hess, A. L., Colson, C., Kjølbæk, Louise, Astrup, A., Gillum, M. P., Larsen, L. H., Liebisch, G., Amri, E. & Klingenspor, M., 2021, In: Molecular Nutrition & Food Research. 65, 2, 15 p., 2000681.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

    Møller, S. H., Mellergaard, M., Madsen, M., Bermejo, A. V., Jepsen, Stine Dam, Hansen, M. H., Høgh, R. I., Aldana, Blanca, Desler, Claus, Rasmussen, Lene Juel, Sustarsic, E. G., Gerhart-Hines, Zach, Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, Hans H., Andresen, Lars & Skov, Søren, 2020, In: Frontiers in Immunology. 11, 22 p., 1968.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis

    Neess, D., Kruse, V., Marcher, A. B., Wæde, M. R., Vistisen, J., Møller, P. M., Petersen, R., Brewer, J. R., Ma, Tao, Colleluori, G., Severi, I., Cinti, S., Gerhart-Hines, Zach, Mandrup, S. & Færgeman, N. J., 2021, In: Molecular Metabolism. 44, 11 p., 101144.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure

    Nicolaisen, T. S., Klein, A. B., Dmytriyeva, O., Lund, Jens, Ingerslev, L. R., Fritzen, Andreas Mæchel, Carl, Christian Strini, Lundsgaard, Anne-Marie, Frost, M., Ma, Tao, Schjerling, P., Gerhart-Hines, Zach, Flamant, F., Gauthier, K., Larsen, Steen, Richter, Erik A., Kiens, Bente & Clemmensen, Christoffer, 2020, In: F A S E B Journal. 34, 11, p. 15480-15491 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    NAMPT-mediated NAD+ biosynthesis is indispensable for adipose tissue plasticity and development of obesity

    Nielsen, K. N., Peics, J., Ma, Tao, Karavaeva, Iuliia, Dall, M., Chubanava, Sabina, Basse, A. L., Dmytriyeva, O., Treebak, Jonas Thue & Gerhart-Hines, Zach, May 2018, In: Molecular Metabolism. 11, p. 178-188 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Keeping fat on time: Circadian control of adipose tissue

    Ninel Hansen, S., Peics, J. & Gerhart-Hines, Zach, Nov 2017, In: Experimental Cell Research. 360, 1, p. 31-34 4 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Genetics and epigenetics of liver cancer

    Ozen, C., Yildiz, G., Dagcan, A. T., Cevik, D., Ors, A., Keles, U., Topel, Hande & Ozturk, M., 25 May 2013, In: New Biotechnology. 30, 4, p. 381-4 4 p.

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

    Pedersen, J. S., Rygg, M. O., Chrøis, K., Sustarsic, E. G., Gerhart-Hines, Zach, Wever Albrechtsen, N. J., Serizawa, R. R., Kristiansen, V. B., Basse, A. L., Boilesen, Astrid Elisabeth Bruun, Olsen, B. H., Hansen, Torben, Gluud, Lise Lotte, Madsbad, Sten, Larsen, S., Bendtsen, Flemming & Dela, Flemming, 2022, In: Nature Communications. 13, 15 p., 2931.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

    Peluso, A. A., Lundgaard, A. T., Babaei, P., Mousovich-Neto, F., Rocha, A. L., Damgaard, M. V., Bak, E. G., Gnanasekaran, T., Dollerup, O. L., Trammell, S. A. J., Nielsen, T. S., Kern, T., Abild, C. B., Sulek, K., Ma, T., Gerhart-Hines, Z., Gillum, M. P., Arumugam, M., Ørskov, C., McCloskey, D. & 4 others, Jessen, N., Herrgård, M. J., Mori, M. A. S. & Treebak, Jonas Thue, 2023, In: npj Aging. 9, 21 p., 7.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice

    Pendergrast, L. A., Ashcroft, Stephen Paul, Ehrlich, Amy M, Treebak, Jonas Thue, Krook, A., Dollet, L. & Zierath, Juleen R, 2024, In: Metabolism: Clinical and Experimental. 155, 12 p., 155834.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Time of day determines postexercise metabolism in mouse adipose tissue

    Pendergrast, L. A., Lundell, L. S., Ehrlich, Amy M, Ashcroft, Stephen Paul, Schönke, M., Basse, A. L., Krook, A., Treebak, Jonas Thue, Dollet, L. & Zierath, Juleen R, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, e2218510120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    TNIK is a conserved regulator of glucose and lipid metabolism in obesity

    Pham, Tang Cam Phung, Dollet, L., Ali, Mona Sadek, Raun, Steffen Henning, Møller, Lisbeth L V, Jafari Kermani, Abbas, Ditzel, N., Andersen, Nicoline Resen, Fritzen, Andreas Mæchel, Gerhart-Hines, Zach, Kiens, Bente, Suomalainen, A., Simpson, S. J., Salling Olsen, M., Kieser, A., Schjerling, Peter, Nieminen, A. I., Richter, Erik A., Havula, E. & Sylow, Lykke, 2023, In: Science Advances. 9, 32, 18 p., eadf7119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment

    Rabiee, A., Plucinska, Kaja, Isidor, Marie Sophie, Brown, E. L., Tozzi, M., Sidoli, S., Petersen, P. S. S., Agueda Oyarzabal, Marina, Torsetnes, S. B., Chehabi, G. N., Lundh, M., Altıntaş, Ali, Barrès, Romain, Jensen, O. N., Gerhart-Hines, Zach & Emanuelli, Brice, 2021, In: Molecular Metabolism. 44, 17 p., 101137.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP

    Rahbani, J. F., Scholtes, C., Lagarde, D. M., Hussain, M. F., Roesler, A., Dykstra, C. B., Bunk, J., Samborska, B., O’Brien, S. L., Tripp, E., Pacis, A., Angueira, A. R., Johansen, O. S., Cinkornpumin, J., Hossain, I., Lynes, M. D., Zhang, Y., White, A. P., Pastor, W. A., Chondronikola, M. & 12 others, Sidossis, L., Klein, S., Kralli, A., Cypess, A. M., Pedersen, S. B., Jessen, N., Tseng, Y. H., Gerhart-Hines, Zach, Seale, P., Calebiro, D., Giguère, V. & Kazak, L., 2022, In: Nature Metabolism. 4, 11, p. 1459-1473

    Research output: Contribution to journal › Letter › Research › peer-review

  16. Published

    The physiology of experimental overfeeding in animals

    Ranea-Robles, Pablo, Lund, Jens & Clemmensen, Christoffer, 2022, In: Molecular Metabolism. 64, 15 p., 101573.

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Housing temperature influences exercise training adaptations in mice

    Raun, Steffen Henning, Henriquez-Olguín, Carlos, Karavaeva, Iuliia, Ali, Mona Sadek, Møller, Lisbeth L V, Kot, Witold, Castro-Mejía, J. L., Nielsen, Dennis Sandris, Gerhart-Hines, Zach, Richter, Erik A. & Sylow, Lykke, 2020, In: Nature Communications. 11, 16 p., 1560.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Metabolic adaptations through the PGC-1α and SIRT1 pathways

    Rodgers, J. T., Lerin, C., Gerhart-Hines, Zach & Puigserver, P., 9 Jan 2008, In: FEBS Letters. 582, 1, p. 46-53 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Full activation of thermogenesis in brown adipocytes requires Basigin action

    Rupar, K., Isidor, Marie Sophie, Argemi Muntadas, Lidia, Agueda Oyarzabal, Marina, Plucinska, Kaja, Brown, E. L., Mattanovich, M., Bossi, Simone, Tozzi, M., Tandio, David, Petersen, P. S. S., Henriksen, T. I., Trošt, K., Hansen, Jacob B., Gerhart-Hines, Zach, Nielsen, S., Moritz, Thomas & Emanuelli, Brice, 2023, In: F E B S Journal. 290, 10, p. 2673-2691

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

    Sass, Frederike, Schlein, C., Jaeckstein, M. Y., Pertzborn, P., Schweizer, M., Schinke, T., Ballabio, A., Scheja, L., Heeren, J. & Fischer, A. W., 1 May 2021, In: Molecular Metabolism. 47, 19 p., 101173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    THU-491-The role of alanine glyoxylate aminotransferase in hepatocellular carcinoma

    Satriano, L., Lewinska, Monika, Rourke, C. O., Oliveira, D. V., Bhatt, D. K., Taranta, A., Herr, M., Straub, B., Conner, D. E. A., Budhu, D. A., Pomyen, Y., Ma, Tao, Gerhart-Hines, Zach, Stjernegaard, D. C. S., Matter, M., Crocoll, D. C., Wang, X. W., Marquardt, J. & Andersen, Jesper Bøje, 2019, p. e377.

    Research output: Contribution to conference › Poster › Research

  22. Published

    Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

    Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Zach, Irie, H. Y., Gao, S., Puigserver, P. & Brugge, J. S., 3 Sep 2009, In: Nature. 461, 7260, p. 109-113 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

    Segref, A., Vakkayil, K. L., Padvitski, T., Li, Q., Kroef, V., Lormann, J., Körner, L., Finger, Fabian Michael & Hoppe, T., 2022, In: Nature Communications. 13, 1, 17 p., 5874.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Atlas of exercise-induced brain activation in mice

    Skovbjerg, G., Fritzen, Andreas Mæchel, Svendsen, C. S. A., Perens, J., Skytte, J. L., Lund, Camilla, Lund, Jens, Madsen, M. R., Roostalu, U., Hecksher-Sørensen, J. & Clemmensen, Christoffer, 2024, In: Molecular Metabolism. 82, 14 p., 101907.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

    Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S-Y., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., Willis, A. E. & 10 others, Lund, Anders H., Treebak, Jonas Thue, Olsen, Jesper Velgaard, Poulsen, Steen Seier, Pownall, M. E., Jensen, Benjamin Anderschou Holbech, Clemmensen, Christoffer, Gerhart-Hines, Zach, Gatfield, D. & Bekker-Jensen, Simon Holst, 2023, In: Science (New York, N.Y.). 382, 6675, 14 p., eadf3208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

    Snieckute, Goda, Genzor Garbayo, Aitana Victoria, Vind, Anna Constance, Jordan, Laura Ryder, Stoneley, M., Chamois, S., Dreos, R., Nordgaard, C., Sass, Frederike, Blasius, Melanie, López, A. R., Brynjólfsdóttir, S. H., Andersen, Kasper Langebjerg, Willis, A. E., Frankel, Lisa, Poulsen, Steen Seier, Gatfield, D., Gerhart-Hines, Zach, Clemmensen, Christoffer & Bekker-Jensen, Simon Holst, 2022, In: Cell Metabolism. 34, 12, p. 2036-2046.e8 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

    Soberg, S., Löfgren, J., Philipsen, F. E., Jensen, M., Hansen, Adam Espe, Ahrens, E., Nystrup, K. B., Nielsen, R. D., Solling, C., Wedell-Neergaard, A., Berntsen, M., Loft, A., Kjær, Andreas, Gerhart-Hines, Zach, Johannesen, H. H., Pedersen, Bente Klarlund, Karstoft, Kristian & Schéele, Camilla Charlotte Nielsen, 2021, In: Cell Reports Medicine. 2, 10, 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

    Suchankova, G., Nelson, L. E., Gerhart-Hines, Zach, Kelly, M., Gauthier, M. S., Saha, A. K., Ido, Y., Puigserver, P. & Ruderman, N. B., 23 Jan 2009, In: Biochemical and Biophysical Research Communications. 378, 4, p. 836-841 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

    Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 others, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, Allan René, Pedersen, Oluf Borbye, Kiebish, M. A., Qvortrup, Klaus, Han, X., Pedersen, Bente Klarlund, Jastroch, M., Mandrup, S., Kjær, Andreas, Gygi, S. P., Hansen, Torben, Gillum, M. P., Grarup, Niels, Emanuelli, Brice, Nielsen, S., Schéele, Camilla Charlotte Nielsen, Tseng, Y., Færgeman, N. J. & Gerhart-Hines, Zach, 2018, In: Cell Metabolism. 28, 1, p. 159-174.e11

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases

    Sveidahl Johansen, O., Ma, Tao & Gerhart-Hines, Zach, 2022, In: Molecular Metabolism. 60, 8 p., 101474.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Fueling the fire of adipose thermogenesis

    Wolfrum, C. & Gerhart-Hines, Zach, 2022, In: Science. 375, 6586, p. 1229-1231 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Signaling Pathways as Potential Therapeutic Targets in Hepatocarcinogenesis

    Yılmaz, Y., Güneş, A., Topel, Hande & Atabey, N., Sep 2017, In: Journal of Gastrointestinal Cancer. 48, 3, p. 225-237 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus

    de Guia, R. M., Hassing, Anna Skab, Skov, Louise Julie, Ratner, C., Plucinska, Kaja, Madsen, S., Diep, T. A., dela Cruz, Gelo, Trammell, Sam, Sustarsic, E. G., Emanuelli, Brice, Gillum, M. P., Gerhart-Hines, Zach, Holst, Birgitte & Treebak, Jonas Thue, 2020, In: Acta Physiologica. 228, 4

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting- and ghrelin-mediated food intake

    de Guia, R. M., Hassing, Anna Skab, Ma, Tao, Plucinska, Kaja, Holst, Birgitte, Gerhart-Hines, Zach, Emanuelli, Brice & Treebak, Jonas Thue, 2021, In: F A S E B Journal. 35, 5, e21450.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

    van den Berg, R., Kooijman, S., Noordam, R., Ramkisoensing, A., Abreu-Vieira, G., Tambyrajah, L. L., Dijk, W., Ruppert, P., Mol, I. M., Kramar, B., Caputo, R., Puig, L. S., de Ruiter, E. M., Kroon, J., Hoekstra, M., van der Sluis, R. J., Meijer, O. C., Willems van Dijk, K., van Kerkhof, L. W. M., Christodoulides, C. & 8 others, Karpe, F., Gerhart-Hines, Zach, Kersten, S., Meijer, J. H., Coomans, C. P., van Heemst, D., Biermasz, N. R. & Rensen, P. C. N., 2018, In: Cell Reports. 22, 13, p. 3521-3533 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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