c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device. / Bagci, Gulsun; Comez, Dehan; Topel, Hande; Yilmaz, Yeliz; Bagirsakci, Ezgi; Gunes, Aysim; Batı Ayaz, Gizem; Tahmaz, Ismail; Bilgen, Muge; Solmaz, Gulhas; Pesen Okvur, Devrim; Atabey, Nese.

In: B B A - Molecular Cell Research, Vol. 1870, No. 8, 12.2023, p. 119557.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bagci, G, Comez, D, Topel, H, Yilmaz, Y, Bagirsakci, E, Gunes, A, Batı Ayaz, G, Tahmaz, I, Bilgen, M, Solmaz, G, Pesen Okvur, D & Atabey, N 2023, 'c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device', B B A - Molecular Cell Research, vol. 1870, no. 8, pp. 119557. https://doi.org/10.1016/j.bbamcr.2023.119557

APA

Bagci, G., Comez, D., Topel, H., Yilmaz, Y., Bagirsakci, E., Gunes, A., Batı Ayaz, G., Tahmaz, I., Bilgen, M., Solmaz, G., Pesen Okvur, D., & Atabey, N. (2023). c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device. B B A - Molecular Cell Research, 1870(8), 119557. https://doi.org/10.1016/j.bbamcr.2023.119557

Vancouver

Bagci G, Comez D, Topel H, Yilmaz Y, Bagirsakci E, Gunes A et al. c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device. B B A - Molecular Cell Research. 2023 Dec;1870(8):119557. https://doi.org/10.1016/j.bbamcr.2023.119557

Author

Bagci, Gulsun ; Comez, Dehan ; Topel, Hande ; Yilmaz, Yeliz ; Bagirsakci, Ezgi ; Gunes, Aysim ; Batı Ayaz, Gizem ; Tahmaz, Ismail ; Bilgen, Muge ; Solmaz, Gulhas ; Pesen Okvur, Devrim ; Atabey, Nese. / c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device. In: B B A - Molecular Cell Research. 2023 ; Vol. 1870, No. 8. pp. 119557.

Bibtex

@article{d7e61591ce2d433d91ff00d4e82bf327,
title = "c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device",
abstract = "Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver.",
keywords = "Humans, Carcinoma, Hepatocellular/pathology, Liver Neoplasms/genetics, Hepatocytes, Cell Line, Tumor Microenvironment",
author = "Gulsun Bagci and Dehan Comez and Hande Topel and Yeliz Yilmaz and Ezgi Bagirsakci and Aysim Gunes and {Batı Ayaz}, Gizem and Ismail Tahmaz and Muge Bilgen and Gulhas Solmaz and {Pesen Okvur}, Devrim and Nese Atabey",
note = "Copyright {\textcopyright} 2023 Elsevier B.V. All rights reserved.",
year = "2023",
month = dec,
doi = "10.1016/j.bbamcr.2023.119557",
language = "English",
volume = "1870",
pages = "119557",
journal = "B B A - Molecular Cell Research",
issn = "0167-4889",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device

AU - Bagci, Gulsun

AU - Comez, Dehan

AU - Topel, Hande

AU - Yilmaz, Yeliz

AU - Bagirsakci, Ezgi

AU - Gunes, Aysim

AU - Batı Ayaz, Gizem

AU - Tahmaz, Ismail

AU - Bilgen, Muge

AU - Solmaz, Gulhas

AU - Pesen Okvur, Devrim

AU - Atabey, Nese

N1 - Copyright © 2023 Elsevier B.V. All rights reserved.

PY - 2023/12

Y1 - 2023/12

N2 - Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver.

AB - Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver.

KW - Humans

KW - Carcinoma, Hepatocellular/pathology

KW - Liver Neoplasms/genetics

KW - Hepatocytes

KW - Cell Line

KW - Tumor Microenvironment

U2 - 10.1016/j.bbamcr.2023.119557

DO - 10.1016/j.bbamcr.2023.119557

M3 - Journal article

C2 - 37549739

VL - 1870

SP - 119557

JO - B B A - Molecular Cell Research

JF - B B A - Molecular Cell Research

SN - 0167-4889

IS - 8

ER -

ID: 389913292