c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device
Research output: Contribution to journal › Journal article › Research › peer-review
Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver.
Original language | English |
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Journal | B B A - Molecular Cell Research |
Volume | 1870 |
Issue number | 8 |
Pages (from-to) | 119557 |
ISSN | 0167-4889 |
DOIs | |
Publication status | Published - Dec 2023 |
Bibliographical note
Copyright © 2023 Elsevier B.V. All rights reserved.
- Humans, Carcinoma, Hepatocellular/pathology, Liver Neoplasms/genetics, Hepatocytes, Cell Line, Tumor Microenvironment
Research areas
ID: 389913292