Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. / Lim, Ji Hong; Gerhart-Hines, Zachary; Dominy, John E.; Lee, Yoonjin; Kim, Sungjin; Tabata, Mitsuhisa; Xiang, Yang K.; Puigserver, Pere.

In: Journal of Biological Chemistry, Vol. 288, No. 10, 08.03.2013, p. 7117-7126.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lim, JH, Gerhart-Hines, Z, Dominy, JE, Lee, Y, Kim, S, Tabata, M, Xiang, YK & Puigserver, P 2013, 'Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex', Journal of Biological Chemistry, vol. 288, no. 10, pp. 7117-7126. https://doi.org/10.1074/jbc.M112.415729

APA

Lim, J. H., Gerhart-Hines, Z., Dominy, J. E., Lee, Y., Kim, S., Tabata, M., Xiang, Y. K., & Puigserver, P. (2013). Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. Journal of Biological Chemistry, 288(10), 7117-7126. https://doi.org/10.1074/jbc.M112.415729

Vancouver

Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M et al. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. Journal of Biological Chemistry. 2013 Mar 8;288(10):7117-7126. https://doi.org/10.1074/jbc.M112.415729

Author

Lim, Ji Hong ; Gerhart-Hines, Zachary ; Dominy, John E. ; Lee, Yoonjin ; Kim, Sungjin ; Tabata, Mitsuhisa ; Xiang, Yang K. ; Puigserver, Pere. / Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 10. pp. 7117-7126.

Bibtex

@article{90f8b872727e493b898fbf0835ce7ef7,
title = "Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex",
abstract = "Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.",
author = "Lim, {Ji Hong} and Zachary Gerhart-Hines and Dominy, {John E.} and Yoonjin Lee and Sungjin Kim and Mitsuhisa Tabata and Xiang, {Yang K.} and Pere Puigserver",
year = "2013",
month = mar,
day = "8",
doi = "10.1074/jbc.M112.415729",
language = "English",
volume = "288",
pages = "7117--7126",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex

AU - Lim, Ji Hong

AU - Gerhart-Hines, Zachary

AU - Dominy, John E.

AU - Lee, Yoonjin

AU - Kim, Sungjin

AU - Tabata, Mitsuhisa

AU - Xiang, Yang K.

AU - Puigserver, Pere

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

AB - Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.

UR - http://www.scopus.com/inward/record.url?scp=84874817589&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.415729

DO - 10.1074/jbc.M112.415729

M3 - Journal article

C2 - 23329830

AN - SCOPUS:84874817589

VL - 288

SP - 7117

EP - 7126

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 10

ER -

ID: 347797209