Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex
Research output: Contribution to journal › Journal article › Research › peer-review
Background: Different fatty acids signal to control intracellular lipid dynamic metabolism. Results: In skeletal muscle cells, oleic acid inducescAMP/PKAand SIRT1 Ser-434 phosphorylation and activity, causingPGC1α deacetylation and increased fatty acid oxidation. Conclusion: Oleic acid signals to the SIRT1-PGC1α complex to increase rates of fatty acid oxidation. Significance: Pharmacological manipulation of the oleic acid signaling pathway might be a therapeutic option for conditions of lipid dysregulation.
| Original language | English |
|---|---|
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 10 |
| Pages (from-to) | 7117-7126 |
| Number of pages | 10 |
| ISSN | 0021-9258 |
| DOIs | |
| Publication status | Published - 8 Mar 2013 |
ID: 347797209