Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

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Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. / Imamura, Minako; Takahashi, Atsushi; Yamauchi, Toshimasa; Hara, Kazuo; Yasuda, Kazuki; Grarup, Niels; Zhao, Wei; Wang, Xu; Huerta-Chagoya, Alicia; Hu, Cheng; Moon, Sanghoon; Long, Jirong; Kwak, Soo Heon; Rasheed, Asif; Saxena, Richa; Ma, Ronald C W; Okada, Yukinori; Iwata, Minoru; Hosoe, Jun; Shojima, Nobuhiro; Iwasaki, Minaka; Fujita, Hayato; Suzuki, Ken; Danesh, John; Jørgensen, Torben; Jørgensen, Marit E; Witte, Daniel R; Brandslund, Ivan; Christensen, Cramer; Hansen, Torben; Mercader, Josep M; Flannick, Jason; Moreno-Macías, Hortensia; Burtt, Noël P; Zhang, Rong; Kim, Young Jin; Zheng, Wei; Singh, Jai Rup; Tam, Claudia H T; Hirose, Hiroshi; Maegawa, Hiroshi; Ito, Chikako; Kaku, Kohei; Watada, Hirotaka; Tanaka, Yasushi; Tobe, Kazuyuki; Kawamori, Ryuzo; Kubo, Michiaki; Cho, Yoon Shin; Chan, Juliana C N; Sanghera, Dharambir; Frossard, Philippe; Park, Kyong Soo; Shu, Xiao-Ou; Kim, Bong-Jo; Florez, Jose C; Tusié-Luna, Teresa; Jia, Weiping; Tai, E Shyong; Pedersen, Oluf; Saleheen, Danish; Maeda, Shiro; Kadowaki, Takashi.

In: Nature Communications, Vol. 7, 10531, 2016.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Imamura, M, Takahashi, A, Yamauchi, T, Hara, K, Yasuda, K, Grarup, N, Zhao, W, Wang, X, Huerta-Chagoya, A, Hu, C, Moon, S, Long, J, Kwak, SH, Rasheed, A, Saxena, R, Ma, RCW, Okada, Y, Iwata, M, Hosoe, J, Shojima, N, Iwasaki, M, Fujita, H, Suzuki, K, Danesh, J, Jørgensen, T, Jørgensen, ME, Witte, DR, Brandslund, I, Christensen, C, Hansen, T, Mercader, JM, Flannick, J, Moreno-Macías, H, Burtt, NP, Zhang, R, Kim, YJ, Zheng, W, Singh, JR, Tam, CHT, Hirose, H, Maegawa, H, Ito, C, Kaku, K, Watada, H, Tanaka, Y, Tobe, K, Kawamori, R, Kubo, M, Cho, YS, Chan, JCN, Sanghera, D, Frossard, P, Park, KS, Shu, X-O, Kim, B-J, Florez, JC, Tusié-Luna, T, Jia, W, Tai, ES, Pedersen, O, Saleheen, D, Maeda, S & Kadowaki, T 2016, 'Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes', Nature Communications, vol. 7, 10531. https://doi.org/10.1038/ncomms10531

APA

Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., Zhao, W., Wang, X., Huerta-Chagoya, A., Hu, C., Moon, S., Long, J., Kwak, S. H., Rasheed, A., Saxena, R., Ma, R. C. W., Okada, Y., Iwata, M., Hosoe, J., ... Kadowaki, T. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications, 7, [10531]. https://doi.org/10.1038/ncomms10531

Vancouver

Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N et al. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications. 2016;7. 10531. https://doi.org/10.1038/ncomms10531

Author

Imamura, Minako ; Takahashi, Atsushi ; Yamauchi, Toshimasa ; Hara, Kazuo ; Yasuda, Kazuki ; Grarup, Niels ; Zhao, Wei ; Wang, Xu ; Huerta-Chagoya, Alicia ; Hu, Cheng ; Moon, Sanghoon ; Long, Jirong ; Kwak, Soo Heon ; Rasheed, Asif ; Saxena, Richa ; Ma, Ronald C W ; Okada, Yukinori ; Iwata, Minoru ; Hosoe, Jun ; Shojima, Nobuhiro ; Iwasaki, Minaka ; Fujita, Hayato ; Suzuki, Ken ; Danesh, John ; Jørgensen, Torben ; Jørgensen, Marit E ; Witte, Daniel R ; Brandslund, Ivan ; Christensen, Cramer ; Hansen, Torben ; Mercader, Josep M ; Flannick, Jason ; Moreno-Macías, Hortensia ; Burtt, Noël P ; Zhang, Rong ; Kim, Young Jin ; Zheng, Wei ; Singh, Jai Rup ; Tam, Claudia H T ; Hirose, Hiroshi ; Maegawa, Hiroshi ; Ito, Chikako ; Kaku, Kohei ; Watada, Hirotaka ; Tanaka, Yasushi ; Tobe, Kazuyuki ; Kawamori, Ryuzo ; Kubo, Michiaki ; Cho, Yoon Shin ; Chan, Juliana C N ; Sanghera, Dharambir ; Frossard, Philippe ; Park, Kyong Soo ; Shu, Xiao-Ou ; Kim, Bong-Jo ; Florez, Jose C ; Tusié-Luna, Teresa ; Jia, Weiping ; Tai, E Shyong ; Pedersen, Oluf ; Saleheen, Danish ; Maeda, Shiro ; Kadowaki, Takashi. / Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. In: Nature Communications. 2016 ; Vol. 7.

Bibtex

@article{2e0c93ae27374961a111185ac6bb0a1a,
title = "Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes",
abstract = "Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.",
author = "Minako Imamura and Atsushi Takahashi and Toshimasa Yamauchi and Kazuo Hara and Kazuki Yasuda and Niels Grarup and Wei Zhao and Xu Wang and Alicia Huerta-Chagoya and Cheng Hu and Sanghoon Moon and Jirong Long and Kwak, {Soo Heon} and Asif Rasheed and Richa Saxena and Ma, {Ronald C W} and Yukinori Okada and Minoru Iwata and Jun Hosoe and Nobuhiro Shojima and Minaka Iwasaki and Hayato Fujita and Ken Suzuki and John Danesh and Torben J{\o}rgensen and J{\o}rgensen, {Marit E} and Witte, {Daniel R} and Ivan Brandslund and Cramer Christensen and Torben Hansen and Mercader, {Josep M} and Jason Flannick and Hortensia Moreno-Mac{\'i}as and Burtt, {No{\"e}l P} and Rong Zhang and Kim, {Young Jin} and Wei Zheng and Singh, {Jai Rup} and Tam, {Claudia H T} and Hiroshi Hirose and Hiroshi Maegawa and Chikako Ito and Kohei Kaku and Hirotaka Watada and Yasushi Tanaka and Kazuyuki Tobe and Ryuzo Kawamori and Michiaki Kubo and Cho, {Yoon Shin} and Chan, {Juliana C N} and Dharambir Sanghera and Philippe Frossard and Park, {Kyong Soo} and Xiao-Ou Shu and Bong-Jo Kim and Florez, {Jose C} and Teresa Tusi{\'e}-Luna and Weiping Jia and Tai, {E Shyong} and Oluf Pedersen and Danish Saleheen and Shiro Maeda and Takashi Kadowaki",
year = "2016",
doi = "10.1038/ncomms10531",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

AU - Imamura, Minako

AU - Takahashi, Atsushi

AU - Yamauchi, Toshimasa

AU - Hara, Kazuo

AU - Yasuda, Kazuki

AU - Grarup, Niels

AU - Zhao, Wei

AU - Wang, Xu

AU - Huerta-Chagoya, Alicia

AU - Hu, Cheng

AU - Moon, Sanghoon

AU - Long, Jirong

AU - Kwak, Soo Heon

AU - Rasheed, Asif

AU - Saxena, Richa

AU - Ma, Ronald C W

AU - Okada, Yukinori

AU - Iwata, Minoru

AU - Hosoe, Jun

AU - Shojima, Nobuhiro

AU - Iwasaki, Minaka

AU - Fujita, Hayato

AU - Suzuki, Ken

AU - Danesh, John

AU - Jørgensen, Torben

AU - Jørgensen, Marit E

AU - Witte, Daniel R

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Hansen, Torben

AU - Mercader, Josep M

AU - Flannick, Jason

AU - Moreno-Macías, Hortensia

AU - Burtt, Noël P

AU - Zhang, Rong

AU - Kim, Young Jin

AU - Zheng, Wei

AU - Singh, Jai Rup

AU - Tam, Claudia H T

AU - Hirose, Hiroshi

AU - Maegawa, Hiroshi

AU - Ito, Chikako

AU - Kaku, Kohei

AU - Watada, Hirotaka

AU - Tanaka, Yasushi

AU - Tobe, Kazuyuki

AU - Kawamori, Ryuzo

AU - Kubo, Michiaki

AU - Cho, Yoon Shin

AU - Chan, Juliana C N

AU - Sanghera, Dharambir

AU - Frossard, Philippe

AU - Park, Kyong Soo

AU - Shu, Xiao-Ou

AU - Kim, Bong-Jo

AU - Florez, Jose C

AU - Tusié-Luna, Teresa

AU - Jia, Weiping

AU - Tai, E Shyong

AU - Pedersen, Oluf

AU - Saleheen, Danish

AU - Maeda, Shiro

AU - Kadowaki, Takashi

PY - 2016

Y1 - 2016

N2 - Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

AB - Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

U2 - 10.1038/ncomms10531

DO - 10.1038/ncomms10531

M3 - Journal article

C2 - 26818947

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 10531

ER -

ID: 156084624