Standard
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. / de Vries, Paul S; Chasman, Daniel I; Sabater-Lleal, Maria; Chen, Ming-Huei; Huffman, Jennifer E; Steri, Maristella; Tang, Weihong; Teumer, Alexander; Marioni, Riccardo E; Grossmann, Vera; Hottenga, Jouke J; Trompet, Stella; Müller-Nurasyid, Martina; Zhao, Jing Hua; Brody, Jennifer A; Kleber, Marcus E; Guo, Xiuqing; Wang, Jie Jin; Auer, Paul L; Attia, John R; Yanek, Lisa R; Ahluwalia, Tarun Veer Singh; Lahti, Jari; Venturini, Cristina; Tanaka, Toshiko; Bielak, Lawrence F; Joshi, Peter K; Rocanin-Arjo, Ares; Kolcic, Ivana; Navarro, Pau; Rose, Lynda M; Oldmeadow, Christopher; Riess, Helene; Mazur, Johanna; Basu, Saonli; Goel, Anuj; Yang, Qiong; Ghanbari, Mohsen; Willemsen, Gonneke; Rumley, Ann; Fiorillo, Edoardo; de Craen, Anton J M; Grotevendt, Anne; Scott, Robert; Taylor, Kent D; Delgado, Graciela E; Yao, Jie; Kifley, Annette; Kooperberg, Charles; Qayyum, Rehan; Lopez, Lorna M; Berentzen, Tina L; Räikkönen, Katri; Mangino, Massimo; Bandinelli, Stefania; Peyser, Patricia A; Wild, Sarah; Trégouët, David-Alexandre; Wright, Alan F; Marten, Jonathan; Zemunik, Tatijana; Morrison, Alanna C; Sennblad, Bengt; Tofler, Geoffrey; de Maat, Moniek P M; de Geus, Eco J C; Lowe, Gordon D; Zoledziewska, Magdalena; Sattar, Naveed; Binder, Harald; Völker, Uwe; Waldenberger, Melanie; Khaw, Kay-Tee; McKnight, Barbara; Huang, Jie; Jenny, Nancy S; Holliday, Elizabeth G; Qi, Lihong; McEvoy, Mark G; Becker, Diane M; Starr, John M; Sarin, Antti-Pekka; Hysi, Pirro G; Hernandez, Dena G; Jhun, Min A; Campbell, Harry; Hamsten, Anders; Rivadeneira, Fernando; McArdle, Wendy L; Slagboom, P Eline; Zeller, Tanja; Koenig, Wolfgang; Psaty, Bruce M; Haritunians, Talin; Liu, Jingmin; Palotie, Aarno; Uitterlinden, André G; Stott, David J; Hofman, Albert; Franco, Oscar H; Polasek, Ozren; Rudan, Igor; Morange, Pierre-Emmanuel; Wilson, James F; Kardia, Sharon L R; Ferrucci, Luigi; Spector, Tim D; Eriksson, Johan G; Hansen, Torben; Deary, Ian J; Becker, Lewis C; Scott, Rodney J; Mitchell, Paul; März, Winfried; Wareham, Nick J; Peters, Annette; Greinacher, Andreas; Wild, Philipp S; Jukema, Jan W; Boomsma, Dorret I; Hayward, Caroline; Cucca, Francesco; Tracy, Russell; Watkins, Hugh; Reiner, Alex P; Folsom, Aaron R; Ridker, Paul M; O'Donnell, Christopher J; Smith, Nicholas L; Strachan, David P; Dehghan, Abbas.
In:
Human Molecular Genetics, Vol. 25, No. 2, 2016, p. 358-370.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
de Vries, PS, Chasman, DI, Sabater-Lleal, M, Chen, M-H, Huffman, JE, Steri, M, Tang, W, Teumer, A, Marioni, RE, Grossmann, V, Hottenga, JJ, Trompet, S, Müller-Nurasyid, M, Zhao, JH, Brody, JA, Kleber, ME, Guo, X, Wang, JJ, Auer, PL, Attia, JR, Yanek, LR
, Ahluwalia, TVS, Lahti, J, Venturini, C, Tanaka, T, Bielak, LF, Joshi, PK, Rocanin-Arjo, A, Kolcic, I, Navarro, P, Rose, LM, Oldmeadow, C, Riess, H, Mazur, J, Basu, S, Goel, A, Yang, Q, Ghanbari, M, Willemsen, G, Rumley, A, Fiorillo, E, de Craen, AJM, Grotevendt, A, Scott, R, Taylor, KD, Delgado, GE, Yao, J, Kifley, A, Kooperberg, C, Qayyum, R, Lopez, LM, Berentzen, TL, Räikkönen, K, Mangino, M, Bandinelli, S, Peyser, PA, Wild, S, Trégouët, D-A, Wright, AF, Marten, J, Zemunik, T, Morrison, AC, Sennblad, B, Tofler, G, de Maat, MPM, de Geus, EJC, Lowe, GD, Zoledziewska, M, Sattar, N, Binder, H, Völker, U, Waldenberger, M, Khaw, K-T, McKnight, B, Huang, J, Jenny, NS, Holliday, EG, Qi, L, McEvoy, MG, Becker, DM, Starr, JM, Sarin, A-P, Hysi, PG, Hernandez, DG, Jhun, MA, Campbell, H, Hamsten, A, Rivadeneira, F, McArdle, WL, Slagboom, PE, Zeller, T, Koenig, W, Psaty, BM, Haritunians, T, Liu, J, Palotie, A, Uitterlinden, AG, Stott, DJ, Hofman, A, Franco, OH, Polasek, O, Rudan, I, Morange, P-E, Wilson, JF, Kardia, SLR, Ferrucci, L, Spector, TD, Eriksson, JG
, Hansen, T, Deary, IJ, Becker, LC, Scott, RJ, Mitchell, P, März, W, Wareham, NJ, Peters, A, Greinacher, A, Wild, PS, Jukema, JW, Boomsma, DI, Hayward, C, Cucca, F, Tracy, R, Watkins, H, Reiner, AP, Folsom, AR, Ridker, PM, O'Donnell, CJ, Smith, NL, Strachan, DP & Dehghan, A 2016, '
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration',
Human Molecular Genetics, vol. 25, no. 2, pp. 358-370.
https://doi.org/10.1093/hmg/ddv454APA
de Vries, P. S., Chasman, D. I., Sabater-Lleal, M., Chen, M-H., Huffman, J. E., Steri, M., Tang, W., Teumer, A., Marioni, R. E., Grossmann, V., Hottenga, J. J., Trompet, S., Müller-Nurasyid, M., Zhao, J. H., Brody, J. A., Kleber, M. E., Guo, X., Wang, J. J., Auer, P. L., ... Dehghan, A. (2016).
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
Human Molecular Genetics,
25(2), 358-370.
https://doi.org/10.1093/hmg/ddv454Vancouver
de Vries PS, Chasman DI, Sabater-Lleal M, Chen M-H, Huffman JE, Steri M et al.
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
Human Molecular Genetics. 2016;25(2):358-370.
https://doi.org/10.1093/hmg/ddv454Author
de Vries, Paul S ; Chasman, Daniel I ; Sabater-Lleal, Maria ; Chen, Ming-Huei ; Huffman, Jennifer E ; Steri, Maristella ; Tang, Weihong ; Teumer, Alexander ; Marioni, Riccardo E ; Grossmann, Vera ; Hottenga, Jouke J ; Trompet, Stella ; Müller-Nurasyid, Martina ; Zhao, Jing Hua ; Brody, Jennifer A ; Kleber, Marcus E ; Guo, Xiuqing ; Wang, Jie Jin ; Auer, Paul L ; Attia, John R ; Yanek, Lisa R ; Ahluwalia, Tarun Veer Singh ; Lahti, Jari ; Venturini, Cristina ; Tanaka, Toshiko ; Bielak, Lawrence F ; Joshi, Peter K ; Rocanin-Arjo, Ares ; Kolcic, Ivana ; Navarro, Pau ; Rose, Lynda M ; Oldmeadow, Christopher ; Riess, Helene ; Mazur, Johanna ; Basu, Saonli ; Goel, Anuj ; Yang, Qiong ; Ghanbari, Mohsen ; Willemsen, Gonneke ; Rumley, Ann ; Fiorillo, Edoardo ; de Craen, Anton J M ; Grotevendt, Anne ; Scott, Robert ; Taylor, Kent D ; Delgado, Graciela E ; Yao, Jie ; Kifley, Annette ; Kooperberg, Charles ; Qayyum, Rehan ; Lopez, Lorna M ; Berentzen, Tina L ; Räikkönen, Katri ; Mangino, Massimo ; Bandinelli, Stefania ; Peyser, Patricia A ; Wild, Sarah ; Trégouët, David-Alexandre ; Wright, Alan F ; Marten, Jonathan ; Zemunik, Tatijana ; Morrison, Alanna C ; Sennblad, Bengt ; Tofler, Geoffrey ; de Maat, Moniek P M ; de Geus, Eco J C ; Lowe, Gordon D ; Zoledziewska, Magdalena ; Sattar, Naveed ; Binder, Harald ; Völker, Uwe ; Waldenberger, Melanie ; Khaw, Kay-Tee ; McKnight, Barbara ; Huang, Jie ; Jenny, Nancy S ; Holliday, Elizabeth G ; Qi, Lihong ; McEvoy, Mark G ; Becker, Diane M ; Starr, John M ; Sarin, Antti-Pekka ; Hysi, Pirro G ; Hernandez, Dena G ; Jhun, Min A ; Campbell, Harry ; Hamsten, Anders ; Rivadeneira, Fernando ; McArdle, Wendy L ; Slagboom, P Eline ; Zeller, Tanja ; Koenig, Wolfgang ; Psaty, Bruce M ; Haritunians, Talin ; Liu, Jingmin ; Palotie, Aarno ; Uitterlinden, André G ; Stott, David J ; Hofman, Albert ; Franco, Oscar H ; Polasek, Ozren ; Rudan, Igor ; Morange, Pierre-Emmanuel ; Wilson, James F ; Kardia, Sharon L R ; Ferrucci, Luigi ; Spector, Tim D ; Eriksson, Johan G ; Hansen, Torben ; Deary, Ian J ; Becker, Lewis C ; Scott, Rodney J ; Mitchell, Paul ; März, Winfried ; Wareham, Nick J ; Peters, Annette ; Greinacher, Andreas ; Wild, Philipp S ; Jukema, Jan W ; Boomsma, Dorret I ; Hayward, Caroline ; Cucca, Francesco ; Tracy, Russell ; Watkins, Hugh ; Reiner, Alex P ; Folsom, Aaron R ; Ridker, Paul M ; O'Donnell, Christopher J ; Smith, Nicholas L ; Strachan, David P ; Dehghan, Abbas. / A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. In: Human Molecular Genetics. 2016 ; Vol. 25, No. 2. pp. 358-370.
Bibtex
@article{5968316b0f604fd5ba18f0682f424149,
title = "A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration",
abstract = "Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120,000 participants of European ancestry (95,806 participants with data on the X chromosome). Approximately 10.7 million SNPs and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci of which 18 were newly identified. There were no genome-wide significant signals on the X chromosome. The lead variants of 5 significant loci were indels. We further identified 6 additional independent signals, including 3 rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.",
author = "{de Vries}, {Paul S} and Chasman, {Daniel I} and Maria Sabater-Lleal and Ming-Huei Chen and Huffman, {Jennifer E} and Maristella Steri and Weihong Tang and Alexander Teumer and Marioni, {Riccardo E} and Vera Grossmann and Hottenga, {Jouke J} and Stella Trompet and Martina M{\"u}ller-Nurasyid and Zhao, {Jing Hua} and Brody, {Jennifer A} and Kleber, {Marcus E} and Xiuqing Guo and Wang, {Jie Jin} and Auer, {Paul L} and Attia, {John R} and Yanek, {Lisa R} and Ahluwalia, {Tarun Veer Singh} and Jari Lahti and Cristina Venturini and Toshiko Tanaka and Bielak, {Lawrence F} and Joshi, {Peter K} and Ares Rocanin-Arjo and Ivana Kolcic and Pau Navarro and Rose, {Lynda M} and Christopher Oldmeadow and Helene Riess and Johanna Mazur and Saonli Basu and Anuj Goel and Qiong Yang and Mohsen Ghanbari and Gonneke Willemsen and Ann Rumley and Edoardo Fiorillo and {de Craen}, {Anton J M} and Anne Grotevendt and Robert Scott and Taylor, {Kent D} and Delgado, {Graciela E} and Jie Yao and Annette Kifley and Charles Kooperberg and Rehan Qayyum and Lopez, {Lorna M} and Berentzen, {Tina L} and Katri R{\"a}ikk{\"o}nen and Massimo Mangino and Stefania Bandinelli and Peyser, {Patricia A} and Sarah Wild and David-Alexandre Tr{\'e}gou{\"e}t and Wright, {Alan F} and Jonathan Marten and Tatijana Zemunik and Morrison, {Alanna C} and Bengt Sennblad and Geoffrey Tofler and {de Maat}, {Moniek P M} and {de Geus}, {Eco J C} and Lowe, {Gordon D} and Magdalena Zoledziewska and Naveed Sattar and Harald Binder and Uwe V{\"o}lker and Melanie Waldenberger and Kay-Tee Khaw and Barbara McKnight and Jie Huang and Jenny, {Nancy S} and Holliday, {Elizabeth G} and Lihong Qi and McEvoy, {Mark G} and Becker, {Diane M} and Starr, {John M} and Antti-Pekka Sarin and Hysi, {Pirro G} and Hernandez, {Dena G} and Jhun, {Min A} and Harry Campbell and Anders Hamsten and Fernando Rivadeneira and McArdle, {Wendy L} and Slagboom, {P Eline} and Tanja Zeller and Wolfgang Koenig and Psaty, {Bruce M} and Talin Haritunians and Jingmin Liu and Aarno Palotie and Uitterlinden, {Andr{\'e} G} and Stott, {David J} and Albert Hofman and Franco, {Oscar H} and Ozren Polasek and Igor Rudan and Pierre-Emmanuel Morange and Wilson, {James F} and Kardia, {Sharon L R} and Luigi Ferrucci and Spector, {Tim D} and Eriksson, {Johan G} and Torben Hansen and Deary, {Ian J} and Becker, {Lewis C} and Scott, {Rodney J} and Paul Mitchell and Winfried M{\"a}rz and Wareham, {Nick J} and Annette Peters and Andreas Greinacher and Wild, {Philipp S} and Jukema, {Jan W} and Boomsma, {Dorret I} and Caroline Hayward and Francesco Cucca and Russell Tracy and Hugh Watkins and Reiner, {Alex P} and Folsom, {Aaron R} and Ridker, {Paul M} and O'Donnell, {Christopher J} and Smith, {Nicholas L} and Strachan, {David P} and Abbas Dehghan",
note = "{\textcopyright} The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
year = "2016",
doi = "10.1093/hmg/ddv454",
language = "English",
volume = "25",
pages = "358--370",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "2",
}
RIS
TY - JOUR
T1 - A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
AU - de Vries, Paul S
AU - Chasman, Daniel I
AU - Sabater-Lleal, Maria
AU - Chen, Ming-Huei
AU - Huffman, Jennifer E
AU - Steri, Maristella
AU - Tang, Weihong
AU - Teumer, Alexander
AU - Marioni, Riccardo E
AU - Grossmann, Vera
AU - Hottenga, Jouke J
AU - Trompet, Stella
AU - Müller-Nurasyid, Martina
AU - Zhao, Jing Hua
AU - Brody, Jennifer A
AU - Kleber, Marcus E
AU - Guo, Xiuqing
AU - Wang, Jie Jin
AU - Auer, Paul L
AU - Attia, John R
AU - Yanek, Lisa R
AU - Ahluwalia, Tarun Veer Singh
AU - Lahti, Jari
AU - Venturini, Cristina
AU - Tanaka, Toshiko
AU - Bielak, Lawrence F
AU - Joshi, Peter K
AU - Rocanin-Arjo, Ares
AU - Kolcic, Ivana
AU - Navarro, Pau
AU - Rose, Lynda M
AU - Oldmeadow, Christopher
AU - Riess, Helene
AU - Mazur, Johanna
AU - Basu, Saonli
AU - Goel, Anuj
AU - Yang, Qiong
AU - Ghanbari, Mohsen
AU - Willemsen, Gonneke
AU - Rumley, Ann
AU - Fiorillo, Edoardo
AU - de Craen, Anton J M
AU - Grotevendt, Anne
AU - Scott, Robert
AU - Taylor, Kent D
AU - Delgado, Graciela E
AU - Yao, Jie
AU - Kifley, Annette
AU - Kooperberg, Charles
AU - Qayyum, Rehan
AU - Lopez, Lorna M
AU - Berentzen, Tina L
AU - Räikkönen, Katri
AU - Mangino, Massimo
AU - Bandinelli, Stefania
AU - Peyser, Patricia A
AU - Wild, Sarah
AU - Trégouët, David-Alexandre
AU - Wright, Alan F
AU - Marten, Jonathan
AU - Zemunik, Tatijana
AU - Morrison, Alanna C
AU - Sennblad, Bengt
AU - Tofler, Geoffrey
AU - de Maat, Moniek P M
AU - de Geus, Eco J C
AU - Lowe, Gordon D
AU - Zoledziewska, Magdalena
AU - Sattar, Naveed
AU - Binder, Harald
AU - Völker, Uwe
AU - Waldenberger, Melanie
AU - Khaw, Kay-Tee
AU - McKnight, Barbara
AU - Huang, Jie
AU - Jenny, Nancy S
AU - Holliday, Elizabeth G
AU - Qi, Lihong
AU - McEvoy, Mark G
AU - Becker, Diane M
AU - Starr, John M
AU - Sarin, Antti-Pekka
AU - Hysi, Pirro G
AU - Hernandez, Dena G
AU - Jhun, Min A
AU - Campbell, Harry
AU - Hamsten, Anders
AU - Rivadeneira, Fernando
AU - McArdle, Wendy L
AU - Slagboom, P Eline
AU - Zeller, Tanja
AU - Koenig, Wolfgang
AU - Psaty, Bruce M
AU - Haritunians, Talin
AU - Liu, Jingmin
AU - Palotie, Aarno
AU - Uitterlinden, André G
AU - Stott, David J
AU - Hofman, Albert
AU - Franco, Oscar H
AU - Polasek, Ozren
AU - Rudan, Igor
AU - Morange, Pierre-Emmanuel
AU - Wilson, James F
AU - Kardia, Sharon L R
AU - Ferrucci, Luigi
AU - Spector, Tim D
AU - Eriksson, Johan G
AU - Hansen, Torben
AU - Deary, Ian J
AU - Becker, Lewis C
AU - Scott, Rodney J
AU - Mitchell, Paul
AU - März, Winfried
AU - Wareham, Nick J
AU - Peters, Annette
AU - Greinacher, Andreas
AU - Wild, Philipp S
AU - Jukema, Jan W
AU - Boomsma, Dorret I
AU - Hayward, Caroline
AU - Cucca, Francesco
AU - Tracy, Russell
AU - Watkins, Hugh
AU - Reiner, Alex P
AU - Folsom, Aaron R
AU - Ridker, Paul M
AU - O'Donnell, Christopher J
AU - Smith, Nicholas L
AU - Strachan, David P
AU - Dehghan, Abbas
N1 - © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PY - 2016
Y1 - 2016
N2 - Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120,000 participants of European ancestry (95,806 participants with data on the X chromosome). Approximately 10.7 million SNPs and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci of which 18 were newly identified. There were no genome-wide significant signals on the X chromosome. The lead variants of 5 significant loci were indels. We further identified 6 additional independent signals, including 3 rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
AB - Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120,000 participants of European ancestry (95,806 participants with data on the X chromosome). Approximately 10.7 million SNPs and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci of which 18 were newly identified. There were no genome-wide significant signals on the X chromosome. The lead variants of 5 significant loci were indels. We further identified 6 additional independent signals, including 3 rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
U2 - 10.1093/hmg/ddv454
DO - 10.1093/hmg/ddv454
M3 - Journal article
C2 - 26561523
VL - 25
SP - 358
EP - 370
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 2
ER -
