A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Research output: Contribution to journal › Journal article › Research › peer-review
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120,000 participants of European ancestry (95,806 participants with data on the X chromosome). Approximately 10.7 million SNPs and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci of which 18 were newly identified. There were no genome-wide significant signals on the X chromosome. The lead variants of 5 significant loci were indels. We further identified 6 additional independent signals, including 3 rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
Original language | English |
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Journal | Human Molecular Genetics |
Volume | 25 |
Issue number | 2 |
Pages (from-to) | 358-370 |
Number of pages | 13 |
ISSN | 0964-6906 |
DOIs | |
Publication status | Published - 2016 |
ID: 150705097