Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
Research output: Contribution to journal › Journal article › peer-review
- Vogelezang et al_BMC Medical Genomics_2022_Vol 15_e124
Final published version, 1.46 MB, PDF document
Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.
Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.
Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.
Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
|Journal||BMC Medical Genomics|
|Number of pages||16|
|Publication status||Published - 2022|
© 2022. The Author(s).
- Head circumference, Infancy, Genetic correlations, Genome-Wide Association Study