Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy

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Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. / Kelstrup, Louise; Clausen, Tine D; Mathiesen, Elisabeth R; Hansen, Torben; Holst, Jens Juul; Damm, Peter.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 5, 2015, p. 1967-75.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kelstrup, L, Clausen, TD, Mathiesen, ER, Hansen, T, Holst, JJ & Damm, P 2015, 'Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 5, pp. 1967-75. https://doi.org/10.1210/jc.2014-3978

APA

Kelstrup, L., Clausen, T. D., Mathiesen, E. R., Hansen, T., Holst, J. J., & Damm, P. (2015). Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. Journal of Clinical Endocrinology and Metabolism, 100(5), 1967-75. https://doi.org/10.1210/jc.2014-3978

Vancouver

Kelstrup L, Clausen TD, Mathiesen ER, Hansen T, Holst JJ, Damm P. Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. Journal of Clinical Endocrinology and Metabolism. 2015;100(5):1967-75. https://doi.org/10.1210/jc.2014-3978

Author

Kelstrup, Louise ; Clausen, Tine D ; Mathiesen, Elisabeth R ; Hansen, Torben ; Holst, Jens Juul ; Damm, Peter. / Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 5. pp. 1967-75.

Bibtex

@article{b9ffc86711ed4b2ca9c6912d8dd66ba2,
title = "Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy",
abstract = "CONTEXT: Fetal exposure to maternal diabetes is associated with increased risk of type 2 diabetes mellitus (T2DM) later in life. The pathogenesis of T2DM involves dysfunction of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as hyperglucagonemia.OBJECTIVE: Our aim was to investigate circulating plasma levels of GLP-1, GIP, and glucagon during the oral glucose tolerance test (OGTT) in adult offspring of women with diabetes in pregnancy.DESIGN AND PARTICIPANTS: We conducted a follow-up study of 567 offspring, aged 18-27 years. We included two groups exposed to maternal diabetes in utero: offspring of women with diet-treated gestational diabetes mellitus (O-GDM; n = 163) or type 1 diabetes (O-T1DM; n = 146). Two reference groups were included: offspring of women with risk factors for GDM, but normoglycemia during pregnancy (O-NoGDM; n = 133) and offspring from the background population (O-BP; n = 125). The subjects underwent a 75-g OGTT with venous samples at 0, 30, and 120 minutes.RESULTS: Fasting plasma levels of GLP-1 were lower in the two diabetes-exposed groups compared to O-BP (O-GDM, P = .040; O-T1DM, P = .008). Increasing maternal blood glucose during OGTT in pregnancy was associated with reduced postprandial suppression of glucagon in the offspring. Lower levels of GLP-1 and higher levels of glucagon during the OGTT were present in offspring characterized by overweight or prediabetes/T2DM at follow-up, irrespective of exposure status.CONCLUSION: Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed.",
author = "Louise Kelstrup and Clausen, {Tine D} and Mathiesen, {Elisabeth R} and Torben Hansen and Holst, {Jens Juul} and Peter Damm",
year = "2015",
doi = "10.1210/jc.2014-3978",
language = "English",
volume = "100",
pages = "1967--75",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy

AU - Kelstrup, Louise

AU - Clausen, Tine D

AU - Mathiesen, Elisabeth R

AU - Hansen, Torben

AU - Holst, Jens Juul

AU - Damm, Peter

PY - 2015

Y1 - 2015

N2 - CONTEXT: Fetal exposure to maternal diabetes is associated with increased risk of type 2 diabetes mellitus (T2DM) later in life. The pathogenesis of T2DM involves dysfunction of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as hyperglucagonemia.OBJECTIVE: Our aim was to investigate circulating plasma levels of GLP-1, GIP, and glucagon during the oral glucose tolerance test (OGTT) in adult offspring of women with diabetes in pregnancy.DESIGN AND PARTICIPANTS: We conducted a follow-up study of 567 offspring, aged 18-27 years. We included two groups exposed to maternal diabetes in utero: offspring of women with diet-treated gestational diabetes mellitus (O-GDM; n = 163) or type 1 diabetes (O-T1DM; n = 146). Two reference groups were included: offspring of women with risk factors for GDM, but normoglycemia during pregnancy (O-NoGDM; n = 133) and offspring from the background population (O-BP; n = 125). The subjects underwent a 75-g OGTT with venous samples at 0, 30, and 120 minutes.RESULTS: Fasting plasma levels of GLP-1 were lower in the two diabetes-exposed groups compared to O-BP (O-GDM, P = .040; O-T1DM, P = .008). Increasing maternal blood glucose during OGTT in pregnancy was associated with reduced postprandial suppression of glucagon in the offspring. Lower levels of GLP-1 and higher levels of glucagon during the OGTT were present in offspring characterized by overweight or prediabetes/T2DM at follow-up, irrespective of exposure status.CONCLUSION: Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed.

AB - CONTEXT: Fetal exposure to maternal diabetes is associated with increased risk of type 2 diabetes mellitus (T2DM) later in life. The pathogenesis of T2DM involves dysfunction of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as hyperglucagonemia.OBJECTIVE: Our aim was to investigate circulating plasma levels of GLP-1, GIP, and glucagon during the oral glucose tolerance test (OGTT) in adult offspring of women with diabetes in pregnancy.DESIGN AND PARTICIPANTS: We conducted a follow-up study of 567 offspring, aged 18-27 years. We included two groups exposed to maternal diabetes in utero: offspring of women with diet-treated gestational diabetes mellitus (O-GDM; n = 163) or type 1 diabetes (O-T1DM; n = 146). Two reference groups were included: offspring of women with risk factors for GDM, but normoglycemia during pregnancy (O-NoGDM; n = 133) and offspring from the background population (O-BP; n = 125). The subjects underwent a 75-g OGTT with venous samples at 0, 30, and 120 minutes.RESULTS: Fasting plasma levels of GLP-1 were lower in the two diabetes-exposed groups compared to O-BP (O-GDM, P = .040; O-T1DM, P = .008). Increasing maternal blood glucose during OGTT in pregnancy was associated with reduced postprandial suppression of glucagon in the offspring. Lower levels of GLP-1 and higher levels of glucagon during the OGTT were present in offspring characterized by overweight or prediabetes/T2DM at follow-up, irrespective of exposure status.CONCLUSION: Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed.

U2 - 10.1210/jc.2014-3978

DO - 10.1210/jc.2014-3978

M3 - Journal article

C2 - 25781355

VL - 100

SP - 1967

EP - 1975

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -

ID: 137419129