Integration of molecular profiles in a longitudinal wellness profiling cohort

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Integration of molecular profiles in a longitudinal wellness profiling cohort. / Tebani, Abdellah; Gummesson, Anders; Zhong, Wen; Koistinen, Ina Schuppe; Lakshmikanth, Tadepally; Olsson, Lisa M.; Boulund, Fredrik; Neiman, Maja; Stenlund, Hans; Hellström, Cecilia; Karlsson, Max J.; Arif, Muhammad; Dodig-Crnković, Tea; Mardinoglu, Adil; Lee, Sunjae; Zhang, Cheng; Chen, Yang; Olin, Axel; Mikes, Jaromir; Danielsson, Hanna; von Feilitzen, Kalle; Jansson, Per Anders; Angerås, Oskar; Huss, Mikael; Kjellqvist, Sanela; Odeberg, Jacob; Edfors, Fredrik; Tremaroli, Valentina; Forsström, Björn; Schwenk, Jochen M.; Nilsson, Peter; Moritz, Thomas; Bäckhed, Fredrik; Engstrand, Lars; Brodin, Petter; Bergström, Göran; Uhlen, Mathias; Fagerberg, Linn.

In: Nature Communications, Vol. 11, No. 1, 4487, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tebani, A, Gummesson, A, Zhong, W, Koistinen, IS, Lakshmikanth, T, Olsson, LM, Boulund, F, Neiman, M, Stenlund, H, Hellström, C, Karlsson, MJ, Arif, M, Dodig-Crnković, T, Mardinoglu, A, Lee, S, Zhang, C, Chen, Y, Olin, A, Mikes, J, Danielsson, H, von Feilitzen, K, Jansson, PA, Angerås, O, Huss, M, Kjellqvist, S, Odeberg, J, Edfors, F, Tremaroli, V, Forsström, B, Schwenk, JM, Nilsson, P, Moritz, T, Bäckhed, F, Engstrand, L, Brodin, P, Bergström, G, Uhlen, M & Fagerberg, L 2020, 'Integration of molecular profiles in a longitudinal wellness profiling cohort', Nature Communications, vol. 11, no. 1, 4487. https://doi.org/10.1038/s41467-020-18148-7

APA

Tebani, A., Gummesson, A., Zhong, W., Koistinen, I. S., Lakshmikanth, T., Olsson, L. M., Boulund, F., Neiman, M., Stenlund, H., Hellström, C., Karlsson, M. J., Arif, M., Dodig-Crnković, T., Mardinoglu, A., Lee, S., Zhang, C., Chen, Y., Olin, A., Mikes, J., ... Fagerberg, L. (2020). Integration of molecular profiles in a longitudinal wellness profiling cohort. Nature Communications, 11(1), [4487]. https://doi.org/10.1038/s41467-020-18148-7

Vancouver

Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM et al. Integration of molecular profiles in a longitudinal wellness profiling cohort. Nature Communications. 2020;11(1). 4487. https://doi.org/10.1038/s41467-020-18148-7

Author

Tebani, Abdellah ; Gummesson, Anders ; Zhong, Wen ; Koistinen, Ina Schuppe ; Lakshmikanth, Tadepally ; Olsson, Lisa M. ; Boulund, Fredrik ; Neiman, Maja ; Stenlund, Hans ; Hellström, Cecilia ; Karlsson, Max J. ; Arif, Muhammad ; Dodig-Crnković, Tea ; Mardinoglu, Adil ; Lee, Sunjae ; Zhang, Cheng ; Chen, Yang ; Olin, Axel ; Mikes, Jaromir ; Danielsson, Hanna ; von Feilitzen, Kalle ; Jansson, Per Anders ; Angerås, Oskar ; Huss, Mikael ; Kjellqvist, Sanela ; Odeberg, Jacob ; Edfors, Fredrik ; Tremaroli, Valentina ; Forsström, Björn ; Schwenk, Jochen M. ; Nilsson, Peter ; Moritz, Thomas ; Bäckhed, Fredrik ; Engstrand, Lars ; Brodin, Petter ; Bergström, Göran ; Uhlen, Mathias ; Fagerberg, Linn. / Integration of molecular profiles in a longitudinal wellness profiling cohort. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{8b8123810ec740a8a8523535e600e780,
title = "Integration of molecular profiles in a longitudinal wellness profiling cohort",
abstract = "An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.",
author = "Abdellah Tebani and Anders Gummesson and Wen Zhong and Koistinen, {Ina Schuppe} and Tadepally Lakshmikanth and Olsson, {Lisa M.} and Fredrik Boulund and Maja Neiman and Hans Stenlund and Cecilia Hellstr{\"o}m and Karlsson, {Max J.} and Muhammad Arif and Tea Dodig-Crnkovi{\'c} and Adil Mardinoglu and Sunjae Lee and Cheng Zhang and Yang Chen and Axel Olin and Jaromir Mikes and Hanna Danielsson and {von Feilitzen}, Kalle and Jansson, {Per Anders} and Oskar Anger{\aa}s and Mikael Huss and Sanela Kjellqvist and Jacob Odeberg and Fredrik Edfors and Valentina Tremaroli and Bj{\"o}rn Forsstr{\"o}m and Schwenk, {Jochen M.} and Peter Nilsson and Thomas Moritz and Fredrik B{\"a}ckhed and Lars Engstrand and Petter Brodin and G{\"o}ran Bergstr{\"o}m and Mathias Uhlen and Linn Fagerberg",
year = "2020",
doi = "10.1038/s41467-020-18148-7",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Integration of molecular profiles in a longitudinal wellness profiling cohort

AU - Tebani, Abdellah

AU - Gummesson, Anders

AU - Zhong, Wen

AU - Koistinen, Ina Schuppe

AU - Lakshmikanth, Tadepally

AU - Olsson, Lisa M.

AU - Boulund, Fredrik

AU - Neiman, Maja

AU - Stenlund, Hans

AU - Hellström, Cecilia

AU - Karlsson, Max J.

AU - Arif, Muhammad

AU - Dodig-Crnković, Tea

AU - Mardinoglu, Adil

AU - Lee, Sunjae

AU - Zhang, Cheng

AU - Chen, Yang

AU - Olin, Axel

AU - Mikes, Jaromir

AU - Danielsson, Hanna

AU - von Feilitzen, Kalle

AU - Jansson, Per Anders

AU - Angerås, Oskar

AU - Huss, Mikael

AU - Kjellqvist, Sanela

AU - Odeberg, Jacob

AU - Edfors, Fredrik

AU - Tremaroli, Valentina

AU - Forsström, Björn

AU - Schwenk, Jochen M.

AU - Nilsson, Peter

AU - Moritz, Thomas

AU - Bäckhed, Fredrik

AU - Engstrand, Lars

AU - Brodin, Petter

AU - Bergström, Göran

AU - Uhlen, Mathias

AU - Fagerberg, Linn

PY - 2020

Y1 - 2020

N2 - An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

AB - An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

U2 - 10.1038/s41467-020-18148-7

DO - 10.1038/s41467-020-18148-7

M3 - Journal article

C2 - 32900998

AN - SCOPUS:85090387884

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4487

ER -

ID: 251692918