Monoamines' role in islet cell function and type 2 diabetes risk

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Monoamines' role in islet cell function and type 2 diabetes risk. / Roberts, Fiona Louise; Cataldo, Luis Rodrigo; Fex, Malin.

In: Trends in Molecular Medicine, Vol. 29, No. 12, 2023, p. 1045-1058.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Roberts, FL, Cataldo, LR & Fex, M 2023, 'Monoamines' role in islet cell function and type 2 diabetes risk', Trends in Molecular Medicine, vol. 29, no. 12, pp. 1045-1058. https://doi.org/10.1016/j.molmed.2023.08.009

APA

Roberts, F. L., Cataldo, L. R., & Fex, M. (2023). Monoamines' role in islet cell function and type 2 diabetes risk. Trends in Molecular Medicine, 29(12), 1045-1058. https://doi.org/10.1016/j.molmed.2023.08.009

Vancouver

Roberts FL, Cataldo LR, Fex M. Monoamines' role in islet cell function and type 2 diabetes risk. Trends in Molecular Medicine. 2023;29(12):1045-1058. https://doi.org/10.1016/j.molmed.2023.08.009

Author

Roberts, Fiona Louise ; Cataldo, Luis Rodrigo ; Fex, Malin. / Monoamines' role in islet cell function and type 2 diabetes risk. In: Trends in Molecular Medicine. 2023 ; Vol. 29, No. 12. pp. 1045-1058.

Bibtex

@article{7388d4ea8cb54c7eb40be7ef91822355,
title = "Monoamines' role in islet cell function and type 2 diabetes risk",
abstract = "The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function, melatonin treatment, and compounds that alter serotonin availability and signaling.",
keywords = "G protein-coupled receptors, insulin secretion, type 2 diabetes mellitus, β-cell dysfunction",
author = "Roberts, {Fiona Louise} and Cataldo, {Luis Rodrigo} and Malin Fex",
note = "Funding Information: This work was supported by grants from the Swedish Research Council ( 2021-01116 to M.F.), the Hjelt Foundation (to M.F.), the Albert P{\aa}hlsson{\textquoteright}s Foundation (to M.F.), and the Crafoord Foundation (to M.F.) and also by grants from the Lund University Diabetes Centre (LUDC) and the Swedish Foundation for Strategic Research Dnr IRC15-0067 (to LUDC-IRC). Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.molmed.2023.08.009",
language = "English",
volume = "29",
pages = "1045--1058",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Ltd. * Trends Journals",
number = "12",

}

RIS

TY - JOUR

T1 - Monoamines' role in islet cell function and type 2 diabetes risk

AU - Roberts, Fiona Louise

AU - Cataldo, Luis Rodrigo

AU - Fex, Malin

N1 - Funding Information: This work was supported by grants from the Swedish Research Council ( 2021-01116 to M.F.), the Hjelt Foundation (to M.F.), the Albert Påhlsson’s Foundation (to M.F.), and the Crafoord Foundation (to M.F.) and also by grants from the Lund University Diabetes Centre (LUDC) and the Swedish Foundation for Strategic Research Dnr IRC15-0067 (to LUDC-IRC). Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function, melatonin treatment, and compounds that alter serotonin availability and signaling.

AB - The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function, melatonin treatment, and compounds that alter serotonin availability and signaling.

KW - G protein-coupled receptors

KW - insulin secretion

KW - type 2 diabetes mellitus

KW - β-cell dysfunction

U2 - 10.1016/j.molmed.2023.08.009

DO - 10.1016/j.molmed.2023.08.009

M3 - Review

C2 - 37722934

AN - SCOPUS:85171279422

VL - 29

SP - 1045

EP - 1058

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 12

ER -

ID: 369983852