Monoamines' role in islet cell function and type 2 diabetes risk
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The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets in vitro. Herein, we focus on the role of serotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing β-cell function, melatonin treatment, and compounds that alter serotonin availability and signaling.
Original language | English |
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Journal | Trends in Molecular Medicine |
Volume | 29 |
Issue number | 12 |
Pages (from-to) | 1045-1058 |
Number of pages | 14 |
ISSN | 1471-4914 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
This work was supported by grants from the Swedish Research Council ( 2021-01116 to M.F.), the Hjelt Foundation (to M.F.), the Albert Påhlsson’s Foundation (to M.F.), and the Crafoord Foundation (to M.F.) and also by grants from the Lund University Diabetes Centre (LUDC) and the Swedish Foundation for Strategic Research Dnr IRC15-0067 (to LUDC-IRC).
Publisher Copyright:
© 2023 The Authors
- G protein-coupled receptors, insulin secretion, type 2 diabetes mellitus, β-cell dysfunction
Research areas
ID: 369983852