Protective succinate-SUCNR1 metabolic stress signaling gone bad

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Protective succinate-SUCNR1 metabolic stress signaling gone bad. / Winther, Sally; Trauelsen, Mette; Schwartz, Thue W.

In: Cell Metabolism, Vol. 33, No. 7, 2021, p. 1276-1278.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Winther, S, Trauelsen, M & Schwartz, TW 2021, 'Protective succinate-SUCNR1 metabolic stress signaling gone bad', Cell Metabolism, vol. 33, no. 7, pp. 1276-1278. https://doi.org/10.1016/j.cmet.2021.06.009

APA

Winther, S., Trauelsen, M., & Schwartz, T. W. (2021). Protective succinate-SUCNR1 metabolic stress signaling gone bad. Cell Metabolism, 33(7), 1276-1278. https://doi.org/10.1016/j.cmet.2021.06.009

Vancouver

Winther S, Trauelsen M, Schwartz TW. Protective succinate-SUCNR1 metabolic stress signaling gone bad. Cell Metabolism. 2021;33(7):1276-1278. https://doi.org/10.1016/j.cmet.2021.06.009

Author

Winther, Sally ; Trauelsen, Mette ; Schwartz, Thue W. / Protective succinate-SUCNR1 metabolic stress signaling gone bad. In: Cell Metabolism. 2021 ; Vol. 33, No. 7. pp. 1276-1278.

Bibtex

@article{336b73fcbd3d4cf09ea0e5a7c6842508,
title = "Protective succinate-SUCNR1 metabolic stress signaling gone bad",
abstract = "The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.",
keywords = "EXTRACELLULAR SUCCINATE, MACROPHAGES",
author = "Sally Winther and Mette Trauelsen and Schwartz, {Thue W.}",
year = "2021",
doi = "10.1016/j.cmet.2021.06.009",
language = "English",
volume = "33",
pages = "1276--1278",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Protective succinate-SUCNR1 metabolic stress signaling gone bad

AU - Winther, Sally

AU - Trauelsen, Mette

AU - Schwartz, Thue W.

PY - 2021

Y1 - 2021

N2 - The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

AB - The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

KW - EXTRACELLULAR SUCCINATE

KW - MACROPHAGES

U2 - 10.1016/j.cmet.2021.06.009

DO - 10.1016/j.cmet.2021.06.009

M3 - Journal article

C2 - 34233171

VL - 33

SP - 1276

EP - 1278

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 7

ER -

ID: 275484275