Age‐dependent decline of NAD+ - universal truth or confounded consensus?

Novo Nordisk Foundation
Center for Basic Metabolic Research

Age‐dependent decline of NAD⁺- universal truth or confounded consensus?

Research output: Contribution to journal › Review › Research › peer-review

Standard

Age‐dependent decline of NAD⁺- universal truth or confounded consensus? / Peluso, A. Augusto; Damgaard, Mads V.; Mori, Marcelo A.S.; Treebak, Jonas T.

In: Nutrients, Vol. 14, No. 1, 101, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Peluso, AA, Damgaard, MV, Mori, MAS & Treebak, JT 2021, 'Age‐dependent decline of NAD⁺- universal truth or confounded consensus?', Nutrients, vol. 14, no. 1, 101. https://doi.org/10.3390/nu14010101

APA

Peluso, A. A., Damgaard, M. V., Mori, M. A. S., & Treebak, J. T. (2021). Age‐dependent decline of NAD⁺- universal truth or confounded consensus? Nutrients, 14(1), [101]. https://doi.org/10.3390/nu14010101

Vancouver

Peluso AA, Damgaard MV, Mori MAS, Treebak JT. Age‐dependent decline of NAD⁺- universal truth or confounded consensus? Nutrients. 2021;14(1). 101. https://doi.org/10.3390/nu14010101

Author

Peluso, A. Augusto ; Damgaard, Mads V. ; Mori, Marcelo A.S. ; Treebak, Jonas T. / Age‐dependent decline of NAD⁺- universal truth or confounded consensus?. In: Nutrients. 2021 ; Vol. 14, No. 1.

Bibtex

@article{ffaac53effcc43d58beef804e12bf7d9,

title = "Age‐dependent decline of NAD+ - universal truth or confounded consensus?",

abstract = "Nicotinamide adenine dinucleotide (NAD+) is an essential molecule involved in various metabolic reactions, acting as an electron donor in the electron transport chain and as a co‐factor for NAD+ ‐dependent enzymes. In the early 2000s, reports that NAD+ declines with aging introduced the notion that NAD+ metabolism is globally and progressively impaired with age. Since then, NAD+ became an attractive target for potential pharmacological therapies aiming to increase NAD+ levels to promote vitality and protect against age‐related diseases. This review summarizes and discusses a collection of studies that report the levels of NAD+ with aging in different species (i.e., yeast, C. elegans, rat, mouse, monkey, and human), to determine whether the notion that overall NAD+ levels decrease with aging stands true. We find that, despite systematic claims of overall changes in NAD+ levels with aging, the evidence to support such claims is very limited and often restricted to a single tissue or cell type. This is particularly true in humans, where the development of NAD+ levels during aging is still poorly characterized. There is a need for much larger, preferably longitudinal, studies to assess how NAD+ levels develop with aging in various tissues. This will strengthen our conclusions on NAD metabolism during aging and should provide a foundation for better pharmacological targeting of relevant tissues.",

keywords = "Aging, C. elegans, Human, Monkey, Mouse, NAD, Rat, Yeast",

author = "Peluso, {A. Augusto} and Damgaard, {Mads V.} and Mori, {Marcelo A.S.} and Treebak, {Jonas T.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the author. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/nu14010101",

language = "English",

volume = "14",

journal = "Nutrients",

issn = "2072-6643",

publisher = "M D P I AG",

number = "1",