Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

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  • Shogo Sato
  • Kenneth A Dyar
  • Kajetan Trost
  • Thomas Kunzke
  • Verena M Prade
  • Astrid Linde Basse
  • Milena Schönke
  • Siwei Chen
  • Muntaha Samad
  • Pierre Baldi
  • Axel Walch
  • Dominik Lutter
  • Paolo Sassone-Corsi

Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.

Original languageEnglish
JournalCell Metabolism
Issue number2
Pages (from-to)329-345.e8
Number of pages26
Publication statusPublished - 2022

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Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

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