Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments

Research output: Contribution to journal › Review › Research › peer-review

Standard

Impaired skeletal muscle regeneration in diabetes : From cellular and molecular mechanisms to novel treatments. / Espino-Gonzalez, Ever; Dalbram, Emilie; Mounier, Rémi; Gondin, Julien; Farup, Jean; Jessen, Niels; Treebak, Jonas T.

In: Cell Metabolism, 07.03.2024.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Espino-Gonzalez, E, Dalbram, E, Mounier, R, Gondin, J, Farup, J, Jessen, N & Treebak, JT 2024, 'Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments', Cell Metabolism. https://doi.org/10.1016/j.cmet.2024.02.014

APA

Espino-Gonzalez, E., Dalbram, E., Mounier, R., Gondin, J., Farup, J., Jessen, N., & Treebak, J. T. (2024). Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments. Cell Metabolism. https://doi.org/10.1016/j.cmet.2024.02.014

Vancouver

Espino-Gonzalez E, Dalbram E, Mounier R, Gondin J, Farup J, Jessen N et al. Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments. Cell Metabolism. 2024 Mar 7. https://doi.org/10.1016/j.cmet.2024.02.014

Author

Espino-Gonzalez, Ever ; Dalbram, Emilie ; Mounier, Rémi ; Gondin, Julien ; Farup, Jean ; Jessen, Niels ; Treebak, Jonas T. / Impaired skeletal muscle regeneration in diabetes : From cellular and molecular mechanisms to novel treatments. In: Cell Metabolism. 2024.

Bibtex

@article{823bcc5f7cce4aa283a40bbbdff1d07d,
title = "Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments",
abstract = "Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration, yet underlying mechanisms and therapeutic treatments remain poorly established. In this review, we describe the cellular and molecular alterations currently known to occur during skeletal muscle regeneration in people with diabetes and animal models of diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, and insulin resistance. We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.",
author = "Ever Espino-Gonzalez and Emilie Dalbram and R{\'e}mi Mounier and Julien Gondin and Jean Farup and Niels Jessen and Treebak, {Jonas T}",
note = "Copyright {\textcopyright} 2024 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2024",
month = mar,
day = "7",
doi = "10.1016/j.cmet.2024.02.014",
language = "English",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - Impaired skeletal muscle regeneration in diabetes

T2 - From cellular and molecular mechanisms to novel treatments

AU - Espino-Gonzalez, Ever

AU - Dalbram, Emilie

AU - Mounier, Rémi

AU - Gondin, Julien

AU - Farup, Jean

AU - Jessen, Niels

AU - Treebak, Jonas T

N1 - Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2024/3/7

Y1 - 2024/3/7

N2 - Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration, yet underlying mechanisms and therapeutic treatments remain poorly established. In this review, we describe the cellular and molecular alterations currently known to occur during skeletal muscle regeneration in people with diabetes and animal models of diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, and insulin resistance. We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.

AB - Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration, yet underlying mechanisms and therapeutic treatments remain poorly established. In this review, we describe the cellular and molecular alterations currently known to occur during skeletal muscle regeneration in people with diabetes and animal models of diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, and insulin resistance. We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.

U2 - 10.1016/j.cmet.2024.02.014

DO - 10.1016/j.cmet.2024.02.014

M3 - Review

C2 - 38490209

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

ER -

ID: 386607465