Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. / Sato, Shogo; Dyar, Kenneth A; Treebak, Jonas T; Jepsen, Sara L; Ehrlich, Amy M; Ashcroft, Stephen P; Trost, Kajetan; Kunzke, Thomas; Prade, Verena M; Small, Lewin; Basse, Astrid Linde; Schönke, Milena; Chen, Siwei; Samad, Muntaha; Baldi, Pierre; Barrès, Romain; Walch, Axel; Moritz, Thomas; Holst, Jens J; Lutter, Dominik; Zierath, Juleen R.; Sassone-Corsi, Paolo.

In: Cell Metabolism, Vol. 34, No. 2, 2022, p. 329-345.e8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sato, S, Dyar, KA, Treebak, JT, Jepsen, SL, Ehrlich, AM, Ashcroft, SP, Trost, K, Kunzke, T, Prade, VM, Small, L, Basse, AL, Schönke, M, Chen, S, Samad, M, Baldi, P, Barrès, R, Walch, A, Moritz, T, Holst, JJ, Lutter, D, Zierath, JR & Sassone-Corsi, P 2022, 'Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis', Cell Metabolism, vol. 34, no. 2, pp. 329-345.e8. https://doi.org/10.1016/j.cmet.2021.12.016

APA

Sato, S., Dyar, K. A., Treebak, J. T., Jepsen, S. L., Ehrlich, A. M., Ashcroft, S. P., Trost, K., Kunzke, T., Prade, V. M., Small, L., Basse, A. L., Schönke, M., Chen, S., Samad, M., Baldi, P., Barrès, R., Walch, A., Moritz, T., Holst, J. J., ... Sassone-Corsi, P. (2022). Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. Cell Metabolism, 34(2), 329-345.e8. https://doi.org/10.1016/j.cmet.2021.12.016

Vancouver

Sato S, Dyar KA, Treebak JT, Jepsen SL, Ehrlich AM, Ashcroft SP et al. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. Cell Metabolism. 2022;34(2):329-345.e8. https://doi.org/10.1016/j.cmet.2021.12.016

Author

Sato, Shogo ; Dyar, Kenneth A ; Treebak, Jonas T ; Jepsen, Sara L ; Ehrlich, Amy M ; Ashcroft, Stephen P ; Trost, Kajetan ; Kunzke, Thomas ; Prade, Verena M ; Small, Lewin ; Basse, Astrid Linde ; Schönke, Milena ; Chen, Siwei ; Samad, Muntaha ; Baldi, Pierre ; Barrès, Romain ; Walch, Axel ; Moritz, Thomas ; Holst, Jens J ; Lutter, Dominik ; Zierath, Juleen R. ; Sassone-Corsi, Paolo. / Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. In: Cell Metabolism. 2022 ; Vol. 34, No. 2. pp. 329-345.e8.

Bibtex

@article{1c5c11c4c8f14cb7b82be818199b59b7,
title = "Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis",
abstract = "Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.",
author = "Shogo Sato and Dyar, {Kenneth A} and Treebak, {Jonas T} and Jepsen, {Sara L} and Ehrlich, {Amy M} and Ashcroft, {Stephen P} and Kajetan Trost and Thomas Kunzke and Prade, {Verena M} and Lewin Small and Basse, {Astrid Linde} and Milena Sch{\"o}nke and Siwei Chen and Muntaha Samad and Pierre Baldi and Romain Barr{\`e}s and Axel Walch and Thomas Moritz and Holst, {Jens J} and Dominik Lutter and Zierath, {Juleen R.} and Paolo Sassone-Corsi",
note = "Copyright {\textcopyright} 2021 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2022",
doi = "10.1016/j.cmet.2021.12.016",
language = "English",
volume = "34",
pages = "329--345.e8",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

AU - Sato, Shogo

AU - Dyar, Kenneth A

AU - Treebak, Jonas T

AU - Jepsen, Sara L

AU - Ehrlich, Amy M

AU - Ashcroft, Stephen P

AU - Trost, Kajetan

AU - Kunzke, Thomas

AU - Prade, Verena M

AU - Small, Lewin

AU - Basse, Astrid Linde

AU - Schönke, Milena

AU - Chen, Siwei

AU - Samad, Muntaha

AU - Baldi, Pierre

AU - Barrès, Romain

AU - Walch, Axel

AU - Moritz, Thomas

AU - Holst, Jens J

AU - Lutter, Dominik

AU - Zierath, Juleen R.

AU - Sassone-Corsi, Paolo

N1 - Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.

AB - Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.

U2 - 10.1016/j.cmet.2021.12.016

DO - 10.1016/j.cmet.2021.12.016

M3 - Journal article

C2 - 35030324

VL - 34

SP - 329-345.e8

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 2

ER -

ID: 290597652