Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. / Massart, Julie; Sjögren, Rasmus J O; Egan, Brendan; Garde, Christian; Lindgren, Magnus; Gu, Weifeng; Ferreira, Duarte M S; Katayama, Mutsumi; Ruas, Jorge L; Barrès, Romain; O'Gorman, Donal J; Zierath, Juleen R; Krook, Anna.

In: Nature Communications, Vol. 12, No. 1, 5948, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Massart, J, Sjögren, RJO, Egan, B, Garde, C, Lindgren, M, Gu, W, Ferreira, DMS, Katayama, M, Ruas, JL, Barrès, R, O'Gorman, DJ, Zierath, JR & Krook, A 2021, 'Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism', Nature Communications, vol. 12, no. 1, 5948. https://doi.org/10.1038/s41467-021-26095-0

APA

Massart, J., Sjögren, R. J. O., Egan, B., Garde, C., Lindgren, M., Gu, W., Ferreira, D. M. S., Katayama, M., Ruas, J. L., Barrès, R., O'Gorman, D. J., Zierath, J. R., & Krook, A. (2021). Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Nature Communications, 12(1), [5948]. https://doi.org/10.1038/s41467-021-26095-0

Vancouver

Massart J, Sjögren RJO, Egan B, Garde C, Lindgren M, Gu W et al. Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Nature Communications. 2021;12(1). 5948. https://doi.org/10.1038/s41467-021-26095-0

Author

Massart, Julie ; Sjögren, Rasmus J O ; Egan, Brendan ; Garde, Christian ; Lindgren, Magnus ; Gu, Weifeng ; Ferreira, Duarte M S ; Katayama, Mutsumi ; Ruas, Jorge L ; Barrès, Romain ; O'Gorman, Donal J ; Zierath, Juleen R ; Krook, Anna. / Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. In: Nature Communications. 2021 ; Vol. 12, No. 1.

Bibtex

@article{8998e58bdccf45278e9223763000a7bb,
title = "Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism",
abstract = "Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Overexpression of miR-19b-3p in human skeletal muscle cells increases insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training. Overexpression of miR-19b-3p in mouse flexor digitorum brevis muscle enhances contraction-induced glucose uptake, indicating that miR-19b-3p exerts control on exercise training-induced adaptations in skeletal muscle. Potential targets of miR-19b-3p that are reduced after aerobic exercise training include KIF13A, MAPK6, RNF11, and VPS37A. Amongst these, RNF11 silencing potentiates glucose uptake in human skeletal muscle cells. Collectively, we identify miR-19b-3p as an aerobic exercise training-induced miRNA that regulates skeletal muscle glucose metabolism.",
author = "Julie Massart and Sj{\"o}gren, {Rasmus J O} and Brendan Egan and Christian Garde and Magnus Lindgren and Weifeng Gu and Ferreira, {Duarte M S} and Mutsumi Katayama and Ruas, {Jorge L} and Romain Barr{\`e}s and O'Gorman, {Donal J} and Zierath, {Juleen R} and Anna Krook",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
doi = "10.1038/s41467-021-26095-0",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

AU - Massart, Julie

AU - Sjögren, Rasmus J O

AU - Egan, Brendan

AU - Garde, Christian

AU - Lindgren, Magnus

AU - Gu, Weifeng

AU - Ferreira, Duarte M S

AU - Katayama, Mutsumi

AU - Ruas, Jorge L

AU - Barrès, Romain

AU - O'Gorman, Donal J

AU - Zierath, Juleen R

AU - Krook, Anna

N1 - © 2021. The Author(s).

PY - 2021

Y1 - 2021

N2 - Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Overexpression of miR-19b-3p in human skeletal muscle cells increases insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training. Overexpression of miR-19b-3p in mouse flexor digitorum brevis muscle enhances contraction-induced glucose uptake, indicating that miR-19b-3p exerts control on exercise training-induced adaptations in skeletal muscle. Potential targets of miR-19b-3p that are reduced after aerobic exercise training include KIF13A, MAPK6, RNF11, and VPS37A. Amongst these, RNF11 silencing potentiates glucose uptake in human skeletal muscle cells. Collectively, we identify miR-19b-3p as an aerobic exercise training-induced miRNA that regulates skeletal muscle glucose metabolism.

AB - Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Overexpression of miR-19b-3p in human skeletal muscle cells increases insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training. Overexpression of miR-19b-3p in mouse flexor digitorum brevis muscle enhances contraction-induced glucose uptake, indicating that miR-19b-3p exerts control on exercise training-induced adaptations in skeletal muscle. Potential targets of miR-19b-3p that are reduced after aerobic exercise training include KIF13A, MAPK6, RNF11, and VPS37A. Amongst these, RNF11 silencing potentiates glucose uptake in human skeletal muscle cells. Collectively, we identify miR-19b-3p as an aerobic exercise training-induced miRNA that regulates skeletal muscle glucose metabolism.

U2 - 10.1038/s41467-021-26095-0

DO - 10.1038/s41467-021-26095-0

M3 - Journal article

C2 - 34642330

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5948

ER -

ID: 282189384