Exerkines in health, resilience and disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Exerkines in health, resilience and disease. / Chow, Lisa S; Gerszten, Robert E; Taylor, Joan M; Pedersen, Bente K; van Praag, Henriette; Trappe, Scott; Febbraio, Mark A; Galis, Zorina S; Gao, Yunling; Haus, Jacob M; Lanza, Ian R; Lavie, Carl J; Lee, Chih-Hao; Lucia, Alejandro; Moro, Cedric; Pandey, Ambarish; Robbins, Jeremy M; Stanford, Kristin I; Thackray, Alice E; Villeda, Saul; Watt, Matthew J; Xia, Ashley; Zierath, Juleen R; Goodpaster, Bret H; Snyder, Michael P.

In: Nature Reviews Endocrinology, Vol. 18, 2022, p. 273-289.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Chow, LS, Gerszten, RE, Taylor, JM, Pedersen, BK, van Praag, H, Trappe, S, Febbraio, MA, Galis, ZS, Gao, Y, Haus, JM, Lanza, IR, Lavie, CJ, Lee, C-H, Lucia, A, Moro, C, Pandey, A, Robbins, JM, Stanford, KI, Thackray, AE, Villeda, S, Watt, MJ, Xia, A, Zierath, JR, Goodpaster, BH & Snyder, MP 2022, 'Exerkines in health, resilience and disease', Nature Reviews Endocrinology, vol. 18, pp. 273-289. https://doi.org/10.1038/s41574-022-00641-2

APA

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., Lanza, I. R., Lavie, C. J., Lee, C-H., Lucia, A., Moro, C., Pandey, A., Robbins, J. M., Stanford, K. I., Thackray, A. E., ... Snyder, M. P. (2022). Exerkines in health, resilience and disease. Nature Reviews Endocrinology, 18, 273-289. https://doi.org/10.1038/s41574-022-00641-2

Vancouver

Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S et al. Exerkines in health, resilience and disease. Nature Reviews Endocrinology. 2022;18:273-289. https://doi.org/10.1038/s41574-022-00641-2

Author

Chow, Lisa S ; Gerszten, Robert E ; Taylor, Joan M ; Pedersen, Bente K ; van Praag, Henriette ; Trappe, Scott ; Febbraio, Mark A ; Galis, Zorina S ; Gao, Yunling ; Haus, Jacob M ; Lanza, Ian R ; Lavie, Carl J ; Lee, Chih-Hao ; Lucia, Alejandro ; Moro, Cedric ; Pandey, Ambarish ; Robbins, Jeremy M ; Stanford, Kristin I ; Thackray, Alice E ; Villeda, Saul ; Watt, Matthew J ; Xia, Ashley ; Zierath, Juleen R ; Goodpaster, Bret H ; Snyder, Michael P. / Exerkines in health, resilience and disease. In: Nature Reviews Endocrinology. 2022 ; Vol. 18. pp. 273-289.

Bibtex

@article{36594beb404f405b8c992562f12e17e3,
title = "Exerkines in health, resilience and disease",
abstract = "The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardiovascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.",
author = "Chow, {Lisa S} and Gerszten, {Robert E} and Taylor, {Joan M} and Pedersen, {Bente K} and {van Praag}, Henriette and Scott Trappe and Febbraio, {Mark A} and Galis, {Zorina S} and Yunling Gao and Haus, {Jacob M} and Lanza, {Ian R} and Lavie, {Carl J} and Chih-Hao Lee and Alejandro Lucia and Cedric Moro and Ambarish Pandey and Robbins, {Jeremy M} and Stanford, {Kristin I} and Thackray, {Alice E} and Saul Villeda and Watt, {Matthew J} and Ashley Xia and Zierath, {Juleen R} and Goodpaster, {Bret H} and Snyder, {Michael P}",
note = "{\textcopyright} 2022. Springer Nature Limited.",
year = "2022",
doi = "10.1038/s41574-022-00641-2",
language = "English",
volume = "18",
pages = "273--289",
journal = "Nature reviews. Endocrinology",
issn = "1759-5029",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Exerkines in health, resilience and disease

AU - Chow, Lisa S

AU - Gerszten, Robert E

AU - Taylor, Joan M

AU - Pedersen, Bente K

AU - van Praag, Henriette

AU - Trappe, Scott

AU - Febbraio, Mark A

AU - Galis, Zorina S

AU - Gao, Yunling

AU - Haus, Jacob M

AU - Lanza, Ian R

AU - Lavie, Carl J

AU - Lee, Chih-Hao

AU - Lucia, Alejandro

AU - Moro, Cedric

AU - Pandey, Ambarish

AU - Robbins, Jeremy M

AU - Stanford, Kristin I

AU - Thackray, Alice E

AU - Villeda, Saul

AU - Watt, Matthew J

AU - Xia, Ashley

AU - Zierath, Juleen R

AU - Goodpaster, Bret H

AU - Snyder, Michael P

N1 - © 2022. Springer Nature Limited.

PY - 2022

Y1 - 2022

N2 - The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardiovascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

AB - The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardiovascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

U2 - 10.1038/s41574-022-00641-2

DO - 10.1038/s41574-022-00641-2

M3 - Review

C2 - 35304603

VL - 18

SP - 273

EP - 289

JO - Nature reviews. Endocrinology

JF - Nature reviews. Endocrinology

SN - 1759-5029

ER -

ID: 300910605