The use of a systems approach to increase NAD+ in human participants

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The use of a systems approach to increase NAD+ in human participants. / Henderson, John D.; Quigley, Sophia N.Z.; Chachra, Shruti S.; Conlon, Nichola; Ford, Dianne.

In: npj Aging, Vol. 10, 7, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Henderson, JD, Quigley, SNZ, Chachra, SS, Conlon, N & Ford, D 2024, 'The use of a systems approach to increase NAD+ in human participants', npj Aging, vol. 10, 7. https://doi.org/10.1038/s41514-023-00134-0

APA

Henderson, J. D., Quigley, S. N. Z., Chachra, S. S., Conlon, N., & Ford, D. (2024). The use of a systems approach to increase NAD+ in human participants. npj Aging, 10, [7]. https://doi.org/10.1038/s41514-023-00134-0

Vancouver

Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D. The use of a systems approach to increase NAD+ in human participants. npj Aging. 2024;10. 7. https://doi.org/10.1038/s41514-023-00134-0

Author

Henderson, John D. ; Quigley, Sophia N.Z. ; Chachra, Shruti S. ; Conlon, Nichola ; Ford, Dianne. / The use of a systems approach to increase NAD+ in human participants. In: npj Aging. 2024 ; Vol. 10.

Bibtex

@article{7e93f5e664814ddebf4aaee3d7596efa,
title = "The use of a systems approach to increase NAD+ in human participants",
abstract = "Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement – Nuchido TIME+{\textregistered} (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.",
author = "Henderson, {John D.} and Quigley, {Sophia N.Z.} and Chachra, {Shruti S.} and Nichola Conlon and Dianne Ford",
note = "Publisher Copyright: {\textcopyright} 2024, The Author(s).",
year = "2024",
doi = "10.1038/s41514-023-00134-0",
language = "English",
volume = "10",
journal = "npj Aging",
issn = "2731-6068",

}

RIS

TY - JOUR

T1 - The use of a systems approach to increase NAD+ in human participants

AU - Henderson, John D.

AU - Quigley, Sophia N.Z.

AU - Chachra, Shruti S.

AU - Conlon, Nichola

AU - Ford, Dianne

N1 - Publisher Copyright: © 2024, The Author(s).

PY - 2024

Y1 - 2024

N2 - Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement – Nuchido TIME+® (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.

AB - Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement – Nuchido TIME+® (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.

U2 - 10.1038/s41514-023-00134-0

DO - 10.1038/s41514-023-00134-0

M3 - Journal article

C2 - 38302501

AN - SCOPUS:85183702814

VL - 10

JO - npj Aging

JF - npj Aging

SN - 2731-6068

M1 - 7

ER -

ID: 383005966