The use of a systems approach to increase NAD+ in human participants

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Final published version, 2.49 MB, PDF document

Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement – Nuchido TIME+® (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.

Original languageEnglish
Article number7
Journalnpj Aging
Number of pages12
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024, The Author(s).

ID: 383005966