- 2024
- Published
Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
Sanchez, C., Colson, C., Gautier, N., Noser, Pascal, Salvi, J., Villet, M., Fleuriot, L., Peltier, C., Schlich, P., Brau, F., Sharif, A., Altıntaş, Ali, Amri, E. Z., Nahon, J. L., Blondeau, N., Benani, A., Barrès, Romain & Rovère, C., 2024, In: Brain, Behavior, and Immunity. 117, p. 330-346 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise induces tissue-specific adaptations to enhance cardiometabolic health
Ashcroft, Stephen Paul, Stocks, Ben Nicholas, Egan, B. & Zierath, Juleen R, 2024, In: Cell Metabolism. 36, 2, p. 278-300Research output: Contribution to journal › Review › Research › peer-review
- Published
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Dollet, L., Lundell, L. S., Chibalin, A. V., Pendergrast, L. A., Pillon, N. J., Lansbury, Elizabeth Laura, Elmastas, M., Frendo-Cumbo, S., Jalkanen, J., de Castro Barbosa, T., Cervone, D. T., Caidahl, K., Dmytriyeva, O., Deshmukh, Atul Shahaji, Barrès, Romain, Rydén, M., Wallberg-Henriksson, H., Zierath, Juleen R & Krook, A., 2024, In: Cell Reports Medicine. 5, 1, 20 p., 101348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploratory physiological experiments are not clinical trials
Richter, Erik A., James, D. E., Kirwan, J. P. & Zierath, Juleen R, 2024, In: Cell Metabolism. 36, 5, p. 882-883Research output: Contribution to journal › Letter › Research › peer-review
- Published
Mass spectrometry-based proteomics approaches to interrogate skeletal muscle adaptations to exercise
Cervone, D. T., Moreno Justicia, Roger, Prats Quesada, Júlia & Deshmukh, Atul Shahaji, 2024, In: Scandinavian Journal of Medicine and Science in Sports. 34, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice
Pendergrast, L. A., Ashcroft, Stephen Paul, Ehrlich, Amy M, Treebak, Jonas Thue, Krook, A., Dollet, L. & Zierath, Juleen R, 2024, In: Metabolism: Clinical and Experimental. 155, 12 p., 155834.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation
Hansen, Signe Schmidt Kjølner, Krautz, Robert, Rago, D., Havelund, J., Stigliani, Arnaud, Færgeman, N. J., Prézelin, A., Rivière, J., Couturier-Tarrade, A., Akimov, V., Blagoev, B., Elfving, B., Neess, D., Vogel, U., Khodosevich, Konstantin, Hougaard, Karin Sørig & Sandelin, Albin Gustav, 2024, In: Nature Communications. 15, 24 p., 4711.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The use of a systems approach to increase NAD+ in human participants
Henderson, John David, Quigley, S. N. Z., Chachra, S. S., Conlon, N. & Ford, D., 2024, In: npj Aging. 10, 12 p., 7.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., Garratt, E. S., Vasiloglou, M. F., Chanvillard, L., Dalbram, E., Ehrlich, A. M., Sanchez-Garcia, J. L., Canto, C., Karagounis, L. G., Treebak, J. T., Migaud, M. E. & 15 others, , 2024, In: Nature Metabolism. 6, 3, p. 433–447Research output: Contribution to journal › Letter › Research › peer-review
- 2023
- Published
Exercise metabolism and adaptation in skeletal muscle
Smith, J. A. B., Murach, K. A., Dyar, K. A. & Zierath, Juleen R, 2023, In: Nature Reviews Molecular Cell Biology. 24, p. 607-632Research output: Contribution to journal › Review › Research › peer-review
- Published
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Brown, A. A., Fernandez-Tajes, J. J., Hong, M. G., Brorsson, C. A., Koivula, R. W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T. D., Forgie, I. M., Adam, J., Allin, K. H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P. J. M., Giordano, G. N., Haid, M., Hansen, T., Hansen, T. H. & 134 others, , 2023, In: Nature Communications. 14, 17 p., 5062.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner
Basse, A. L., Nielsen, K. N., Karavaeva, Iuliia, Ingerslev, L. R., Ma, Tao, Havelund, J. F., Nielsen, Thomas Svava, Frost, M., Peics, J., Kellezi, Emilie Dalbram, Dall, M., Zierath, Juleen R, Barrès, Romain, Færgeman, N. J., Treebak, Jonas Thue & Gerhart-Hines, Zach, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2220102120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise
Ashcroft, Stephen Paul, Jepsen, Sara Lind, Ehrlich, Amy M, Treebak, Jonas Thue, Holst, Jens Juul & Zierath, Juleen R, 2023, In: STAR Protocols. 4, 1, 11 p., 101985.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Seasonal light hours modulate peripheral clocks and energy metabolism in mice
Small, Lewin Barkla, Lundell, L. S., Iversen, Jo Frøkjær, Ehrlich, Amy M, Dall, M., Basse, A. L., Kellezi, Emilie Dalbram, Hansen, Ann Normann, Treebak, Jonas Thue, Barrès, Romain & Zierath, Juleen R, 2023, In: Cell Metabolism. 35, 10, p. 1722-1735.e5 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural elucidation of 3-nitrophenylhydrazine derivatives of tricarboxylic acid cycle acids and optimization of their fragmentation to boost sensitivity in liquid chromatography-mass spectrometry
Hodek, O., Henderson, John David, Argemi Muntadas, Lidia, Khan, Adnan & Moritz, Thomas, 2023, In: Journal of Chromatography - B. 1222, 9 p., 123719.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time of day determines postexercise metabolism in mouse adipose tissue
Pendergrast, L. A., Lundell, L. S., Ehrlich, Amy M, Ashcroft, Stephen Paul, Schönke, M., Basse, A. L., Krook, A., Treebak, Jonas Thue, Dollet, L. & Zierath, Juleen R, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, e2218510120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise
Dent, J. R., Stocks, Ben Nicholas, Campelj, D. G. & Philp, A., 2023, In: Seminars in Cell and Developmental Biology. 143, p. 3-16Research output: Contribution to journal › Review › Research › peer-review
- 2022
- Published
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato, S., Dyar, K. A., Treebak, J. T., Jepsen, S. L., Ehrlich, A. M., Ashcroft, S. P., Trost, K., Kunzke, T., Prade, V. M., Small, L., Basse, A. L., Schönke, M., Chen, S., Samad, M., Baldi, P., Barrès, R., Walch, A., Moritz, T., Holst, J. J., Lutter, D. & 2 others, , 2022, In: Cell Metabolism. 34, 2, p. 329-345.e8 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice
Small, Lewin Barkla, Ehrlich, Amy M, Iversen, Jo Frøkjær, Ashcroft, Stephen Paul, Trošt, K., Moritz, Thomas, Hartmann, Bolette, Holst, Jens Juul, Treebak, Jonas Thue, Zierath, Juleen R & Barrès, Romain, 2022, In: Molecular Metabolism. 57, 8 p., 101440.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation
Moharrek, Farideh, Ingerslev, L. R., Altıntaş, Ali, Lundell, L., Hansen, Ann Normann, Small, Lewin Barkla, Workman, C. T. & Barrès, Romain, 2022, In: Epigenomics. 14, 21, p. 1305-1324 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering inhibitory activity of flavonoids against tau protein kinases: a coupled molecular docking and quantum chemical study
Rasouli, H., Hosseini Ghazvini, S. M. B., Yarani, R., Altıntaş, Ali, Jooneghani, S. G. N. & Ramalho, T. C., 2022, In: Journal of Biomolecular Structure & Dynamics. 40, 1, p. 411-424 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice
Tozzi, M., Brown, E. L., Petersen, P. S., Lundh, M., Isidor, Marie Sophie, Plucinska, Kaja, Nielsen, Thomas Svava, Agueda Oyarzabal, Marina, Small, Lewin Barkla, Treebak, Jonas Thue & Emanuelli, Brice, 2022, In: The Journal of Physiology. 600, 4, p. 885-902Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial
Savikj, M., Stocks, Ben Nicholas, Sato, S., Caidahl, K., Krook, A., Deshmukh, Atul Shahaji, Zierath, Juleen R & Wallberg-Henriksson, H., 2022, In: Metabolism. 135, 14 p., 155268.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., Lanza, I. R., Lavie, C. J., Lee, C-H., Lucia, A., Moro, C., Pandey, A., Robbins, J. M., Stanford, K. I., Thackray, A. E., Villeda, S. & 5 others, , 2022, In: Nature Reviews Endocrinology. 18, p. 273-289Research output: Contribution to journal › Review › Research › peer-review
- Published
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, , 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-intensity interval training remodels the proteome and acetylome of human skeletal muscle
Hostrup, Morten, Lemminger, A. K., Stocks, Ben Nicholas, Gonzalez-Franquesa, A., Larsen, Jeppe Kjærgaard, Prats Quesada, Júlia, Thomassen, Martin, Weinert, B. T., Bangsbo, Jens & Deshmukh, Atul Shahaji, 2022, In: eLife. 11, 37 p., 69802.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism
Belda, E., Voland, L., Tremaroli, V., Falony, G., Adriouch, S., Assmann, K. E., Prifiti, E., Aron-Wisnewsky, J., Debedat, J., Le Roy, T., Nielsen, T., Amouyal, C., Andre, S., Andreelli, F., Blueher, M., Chakaroun, R., Chilloux, J., Coelho, L. P., Dao, M. C., Das, P. & 42 others, , 2022, In: Gut. 71, 12, p. 2463-2480 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes
Isidor, Marie Sophie, Dong, W., Servin-Uribe, R. I., Villarroel, J., Altıntaş, Ali, Ayala-Sumuano, J. T., Varela-Echavarría, A., Barrès, Romain, Stephanopoulos, G., Macotela, Y. & Emanuelli, Brice, 2022, In: International Journal of Obesity. 46, 3, p. 535-543Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation
Stocks, Ben Nicholas, Gonzalez-Franquesa, A., Borg, M. L., Björnholm, M., Niu, Lili, Zierath, Juleen R & Deshmukh, Atul Shahaji, 2022, In: Molecular and Cellular Proteomics. 21, 3, 19 p., 100207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity
Damgaard, Mads Vargas, Nielsen, Thomas Svava, Basse, A. L., Chubanava, Sabina, Trost, K., Moritz, Thomas, Dellinger, R. W., Larsen, Steen & Treebak, Jonas Thue, 2022, In: iScience. 25, 2, 21 p., 103863.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers
Pillon, N. J., Puig, L. S., Altıntaş, Ali, Kamble, P. G., Casaní-Galdón, S., Gabriel, B. M., Barrès, Romain, Conesa, A., Chibalin, A. V., Näslund, E., Krook, A. & Zierath, Juleen R, 2022, In: Life Science Alliance. 6, 1, 14 p., e202201598.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Post-translational modifications: The signals at the intersection of exercise, glucose uptake and insulin sensitivity
Stocks, Ben Nicholas & Zierath, Juleen R, 2022, In: Endocrine Reviews. 43, 4, p. 654-677 24 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Protocol to characterize mitochondrial supercomplexes from mouse tissues by combining BN-PAGE and MS-based proteomics
Moreno Justicia, Roger, Gonzalez-Franquesa, A., Stocks, Ben Nicholas & Deshmukh, Atul Shahaji, 2022, In: STAR Protocols. 3, 1, 21 p., 101135.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes
Damgaard, Mads Vargas, Jepsen, Sara Lind, Ashcroft, Stephen Paul, Holst, Jens Juul & Treebak, Jonas Thue, 2022, In: Nutrients. 14, 18, 11 p., 3741.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reply to ‘Lactate as a major myokine and exerkine’
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., Lanza, I. R., Lavie, C. J., Lee, C. H., Lucia, A., Moro, C., Pandey, A., Robbins, J. M., Stanford, K. I., Thackray, A. E., Villeda, S. & 5 others, , 2022, In: Nature Reviews Endocrinology. 18, 11, p. 713 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Transforming growth factor β1 impairs the transcriptomic response to contraction in myotubes from women with polycystic ovary syndrome
McIlvenna, L. C., Altıntaş, Ali, Patten, R. K., McAinch, A. J., Rodgers, R. J., Stepto, N. K., Barrès, Romain & Moreno-Asso, A., 2022, In: The Journal of Physiology. 600, 14, p. 3313-3330Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zeitgebers of skeletal muscle and implications for metabolic health
Gabriel, B. M. & Zierath, Juleen R, 2022, In: Journal of Physiology. 600, 5, p. 1027-1036Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity
Basse, A. L., Agerholm, M., Farup, J., Dalbram, E., Nielsen, J., Ørtenblad, N., Altıntaş, A., Ehrlich, A. M., Krag, T., Bruzzone, S., Dall, M., de Guia, R. M., Jensen, J. B., Møller, A. B., Karlsen, A., Kjær, M., Barrès, R., Vissing, J., Larsen, S., Jessen, N. & 1 others, , 2021, In: Molecular Metabolism. 53, 101271.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity
Small, Lewin Barkla, Ingerslev, L. R., Manitta, Eleonora, Laker, R. C., Hansen, Ann Normann, Deeney, B., Carrie, A., Couvert, P. & Barrès, Romain, 2021, In: PLOS Genetics. 17, 1, 24 p., 1009325.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic
Tessier, C. M., Kokkinos, A., Mingrone, G., Koliaki, C., Zierath, Juleen R & Mantzoros, C. S., 2021, In: Metabolism. 119, 154769.Research output: Contribution to journal › Editorial › Research
- Published
Cold-induction of afadin in brown fat supports its thermogenic capacity
Lundh, M., Altıntaş, Ali, Tozzi, M., Fabre, O., Ma, Tao, Shamsi, F., Gerhart-Hines, Zach, Barrès, Romain, Tseng, Y. & Emanuelli, Brice, 2021, In: Scientific Reports. 11, 11 p., 9794.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W., Sanders, M. J. & 4 others, , 2021, In: Molecular Metabolism. 51, 18 p., 101228.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of thymosin β4 as a human exerkine and growth factor
Gonzalez-Franquesa, A., Stocks, Ben Nicholas, Borg, M. L., Kuefner, M., Kellezi, Emilie Dalbram, Nielsen, Thomas Svava, Agrawal, A., Pankratova, Stanislava, Chibalin, A. V., Karlsson, H. K. R., Gheibi, S., Björnholm, M., Jørgensen, Niklas Rye, Clemmensen, Christoffer, Treebak, Jonas Thue, Hostrup, Morten, Krook, A., Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: American Journal of Physiology: Cell Physiology. 321, 5, p. C770-C778 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Gabriel, B. M., Altıntaş, Ali, Smith, J. A. B., Sardon-Puig, L., Zhang, X., Basse, A. L., Laker, R. C., Gao, H., Liu, Z., Dollet, L., Treebak, Jonas Thue, Zorzano, A., Huo, Z., Rydén, M., Lanner, J. T., Esser, K. A., Barrès, Romain, Pillon, N. J., Krook, A. & Zierath, Juleen R, 2021, In: Science Advances. 7, 43, 20 p., eabi9654.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of lifestyle intervention in tissue‐specific lipidomic profile of formerly obese mice
Dahdah, N., Gonzalez‐franquesa, A., Samino, S., Gama‐perez, P., Herrero, L., Perales, J. C., Yanes, O., Malagón, M. D. M. & Garcia‐roves, P. M., 2021, In: International Journal of Molecular Sciences. 22, 7, 18 p., 3694.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
Massart, J., Sjögren, R. J. O., Egan, B., Garde, C., Lindgren, M., Gu, W., Ferreira, D. M. S., Katayama, M., Ruas, J. L., Barrès, Romain, O'Gorman, D. J., Zierath, Juleen R & Krook, A., 2021, In: Nature Communications. 12, 1, 13 p., 5948.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health
Williams, K., Carrasquilla, Germán D., Ingerslev, L. R., Hochreuter, Mette Yde, Hansson, Svenja, Pillon, N. J., Donkin, I., Versteyhe, S., Zierath, Juleen R, Kilpeläinen, Tuomas O. & Barrès, Romain, 2021, In: Molecular Metabolism. 53, 13 p., 101290.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring
Laker, R. C. C., Altıntaş, Ali, Lillard, T. S., Zhang, M., Connelly, J. J., Sabik, O. L., Onengut, S., Rich, S. S., Farber, C. R., Barrès, Romain & Yan, Z., 2021, In: Journal of Applied Physiology. 130, 3, p. 605-616Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin and 5-aminoimidazole-4-carboxamide ribonucleotide (Aicar) differentially regulate the skeletal muscle cell secretome
Gonzalez-Franquesa, A., Peijs, Lone, Cervone, D. T., Koçana, C., Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: Proteomes. 9, 3, 16 p., 37.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity
Gonzalez-Franquesa, A., Stocks, Ben Nicholas, Chubanava, Sabina, Hattel, H. B., Moreno Justicia, Roger, Peijs, Lone, Treebak, Jonas Thue, Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: Cell Reports. 35, 8, 20 p., 109180.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
Pillon, N. J., Loos, R. J. F., Marshall, S. M. & Zierath, Juleen R, 2021, In: Cell. 184, 6, p. 1530-1544 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome
Moreno-Asso, A., Altıntaş, Ali, McIlvenna, L. C., Patten, R. K., Botella, J., McAinch, A. J., Rodgers, R. J., Barrès, Romain & Stepto, N. K., 2021, In: Journal of Molecular Endocrinology. 68, 1, p. 63-76Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action
Altıntaş, Ali, Liu, J., Fabre, O., Chuang, T., Wang, Y., Sakurai, R., Chehabi, G. N., Barrès, Romain & Rehan, V. K., 2021, In: F A S E B Journal. 35, 7, e21702.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
Karlsson, H. K. R., Kasahara, A., Ikeda, M., Chibalin, A. V., Harada, J., Rydén, M., Krook, A., Kato, M., Kubota, K. & Zierath, Juleen R, 2021, In: Metabolism. 118, 7 p., 154726.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle
Maasar, M. F., Turner, D. C., Gorski, P. P., Seaborne, R. A., Strauss, J. A., Shepherd, S. O., Cocks, M., Pillon, N. J., Zierath, Juleen R, Hulton, A. T., Drust, B. & Sharples, A. P., 2021, In: Frontiers in Physiology. 12, 17 p., 619447.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of the molecular circadian clock in human energy homeostasis
Dollet, L., Pendergrast, L. A. & Zierath, Juleen R, 2021, In: Current Opinion in Lipidology. 32, 1, p. 16-23 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment
Rabiee, A., Plucinska, Kaja, Isidor, Marie Sophie, Brown, E. L., Tozzi, M., Sidoli, S., Petersen, P. S. S., Agueda Oyarzabal, Marina, Torsetnes, S. B., Chehabi, G. N., Lundh, M., Altıntaş, Ali, Barrès, Romain, Jensen, O. N., Gerhart-Hines, Zach & Emanuelli, Brice, 2021, In: Molecular Metabolism. 44, 17 p., 101137.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
Batista, T. M., Jayavelu, A. K., Albrechtsen, Nicolai Jacob Wewer, Iovino, S., Lebastchi, J., Pan, H., Dreyfuss, J. M., Krook, A., Zierath, Juleen R, Mann, Matthias & Kahn, C. R., 2020, In: Cell Metabolism. 32, 5, p. 844-859.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
Hawley, J. A., Sassone-Corsi, P. & Zierath, Juleen R, 2020, In: Diabetologia. 63, 11, p. 2253-2259 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism
Abdelmoez, A. M., Puig, L. S., Smith, J. A. B., Gabriel, B. M., Savikj, M., Dollet, L., Chibalin, A. V., Krook, A., Zierath, Juleen R & Pillon, N. J., 2020, In: American Journal of Physiology: Cell Physiology. 318, 3, p. C615-C626 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway
Small, Lewin Barkla, Altıntaş, Ali, Laker, R. C., Ehrlich, Amy M, Pattamaprapanont, P., Villarroel, J., Pillon, N. J., Zierath, Juleen R & Barrès, Romain, 2020, In: The Journal of Physiology. 598, 24, p. 5739-5752Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise
Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S., Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D., Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., Emanuelli, B. & 6 others, , 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23932-23941Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression
Puig, L. S., Pillon, N. J., Naslund, E., Krook, A. & Zierath, Juleen R, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 318, 1, p. E1-E10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes
Ardenkjær-Larsen, J., Rupar, K., Snieckute, Goda, Petersen, P. S. S., Villarroel, J., Lundh, M., Barrès, Romain, Rabiee, A. & Emanuelli, Brice, 2020, In: Adipocyte (Philadelphia). 9, 1, p. 142-152 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research
Gonzalez-Franquesa, A., Carrasquilla Lopez, G. D., Mamidi, A., Ghiasi, S. M., Juel, H. B., Falk, S., Isidor, M. S., Gillberg, L. M. E., Huang, L. O., Quist, J. S., Knudsen, J. R., Quaranta, R., Tozzi, M., Mikkelsen, R. B., Dall, M., Drag, M. H., Small, L. B., Altıntaş, A., Osborne, B., Modvig, I. M. & 11 others, , 2020, In: Acta Physiologica. 229, 2, 5 p., e13455.Research output: Contribution to journal › Comment/debate › Research
- Published
Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men
Dollerup, O. L., Chubanava, Sabina, Agerholm, M., Søndergård, S. D., Altıntaş, Ali, Møller, A. B., Høyer, K. F., Ringgaard, S., Stødkilde-Jørgensen, H., Lavery, G. G., Barrès, Romain, Larsen, Steen, Prats Gavalda, Clara, Jessen, N. & Treebak, Jonas Thue, 2020, In: Journal of Physiology. 598, 4, p. 731-754Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes
Isidor, Marie Sophie, Winther, Sally, Markussen, L. K., Basse, A. L., Quistorff, B., Nedergaard, J., Emanuelli, Brice & Hansen, Jacob B., 2020, In: FEBS Letters. 594, 7, p. 1218-1225Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
Williams, K., Ingerslev, L. R., Bork-Jensen, J., Wohlwend, M., Hansen, Ann Normann, Small, Lewin Barkla, Ribel-Madsen, R., Astrup, A., Pedersen, Oluf Borbye, Auwerx, J., Workman, C. T., Grarup, Niels, Hansen, Torben & Barrès, Romain, 2020, In: Nature Communications. 11, 16 p., 2695.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression: [Author Correction]
Lundell, L. S., Parr, E. B., Devlin, B. L., Ingerslev, L. R., Altıntaş, Ali, Sato, S., Sassone-Corsi, P., Barrès, Romain, Zierath, Juleen R & Hawley, J. A., 2020, In: Nature Communications. 11, 1, 11 p., 4643.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Train like an athlete: applying exercise interventions to manage type 2 diabetes
Savikj, M. & Zierath, Juleen R, 2020, In: Diabetologia. 63, 8, p. 1491-1499Research output: Contribution to journal › Review › Research › peer-review
- Published
Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development
Altıntaş, Ali, Laker, R. C., Garde, C., Barrès, Romain & Zierath, Juleen R, 2020, In: Epigenomics. 12, 8, p. 701-713Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Pillon, N. J., Gabriel, B. M., Dollet, L., Smith, J. A. B., Puig, L. S., Botella, J., Bishop, D. J., Krook, A. & Zierath, Juleen R, 2020, In: Nature Communications. 11, 1, 15 p., 470.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue
Pardo, R., Vila, M., Cervela, L., de Marco, M., Gama-Perez, P., Gonzalez-Franquesa, A., Statuto, L., Vilallonga, R., Simo, R., Garcia-Roves, P. M. & Villena, J. A., 2019, In: FASEB Journal. 33, 2, p. 2343-2358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circadian rhythms and exercise - re-setting the clock in metabolic disease
Gabriel, B. M. & Zierath, Juleen R, 2019, In: Nature Reviews Endocrinology. 15, 4, p. 197-206Research output: Contribution to journal › Review › Research › peer-review
- Published
Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes
Andersen, E., Altıntaş, Ali, Andersson-Hall, U., Holmäng, A. & Barrès, Romain, 2019, In: Epigenomics. 11, 8, p. 861-873 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic reprogramming of immune cells in women with PCOS impact genes controlling reproductive function
Hiam, D., Simar, D., Laker, R., Altıntaş, Ali, Gibson-Helm, M., Fletcher, E., Moreno-Asso, A., Trewin, A. J., Barrès, Romain & Stepto, N. K., 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6155-6170Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
Jespersen, N. Z., Feizi, A., Andersen, E. S., Heywood, S., Hattel, H. B., Daugaard, S., Peijs, Lone, Bagi, P., Feldt-Rasmussen, Bo, Schultz, H. S., Hansen, N. S., Krogh-Madsen, Rikke, Pedersen, Bente Klarlund, Petrovic, N., Nielsen, S. & Schéele, Camilla Charlotte Nielsen, 2019, In: Molecular Metabolism. 24, p. 30-43 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Hochreuter, Mette Yde, Altıntaş, Ali, Garde, C., Emanuelli, Brice, Kahn, C. R., Zierath, Juleen R, Vienberg, S. & Barrès, Romain, 2019, In: Hepatology Research. 49, 12, p. 1451-1465Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue
Dollet, L. & Zierath, Juleen R, 2019, In: Journal of Physiology. 597, 6, p. 1439-1450Research output: Contribution to journal › Review › Research › peer-review
- Published
Mechanisms preserving insulin action during high dietary fat intake
Lundsgaard, Anne-Marie, Holm, J. B., Sjøberg, K. A., Bojsen-Møller, K. N., Myrmel, L. S., Fjære, E., Jensen, Benjamin Anderschou Holbech, Nicolaisen, T. S., Hingst, J. R., Hansen, S. L., Doll, S., Geyer, P. E., Deshmukh, Atul Shahaji, Holst, Jens Juul, Madsen, L., Kristiansen, Karsten, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2019, In: Cell Metabolism. 29, 1, p. 50-63, e1-e4 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation
Batth, Tanveer Singh, Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, Simon Holst, Deshmukh, Atul Shahaji & Olsen, Jesper Velgaard, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine
Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, , 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle
Lundell, L. S., Massart, J., Altıntaş, Ali, Krook, A. & Zierath, Juleen R, 2019, In: Molecular Metabolism. 20, p. 79-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis
Massart, J. & Zierath, Juleen R, 2019, In: Trends in Endocrinology and Metabolism. 30, 9, p. 603-617Research output: Contribution to journal › Review › Research › peer-review
- Published
Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis
Sato, S., Basse, A. L., Schönke, M., Chen, S., Samad, M., Altıntaş, Ali, Laker, R. C., Kellezi, Emilie Dalbram, Barrès, Romain, Baldi, P., Treebak, Jonas Thue, Zierath, Juleen R & Sassone-Corsi, P., 2019, In: Cell Metabolism. 30, 1, p. 92-110.e4 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action
Kellezi, Emilie Dalbram, Basse, A. L., Zierath, Juleen R & Treebak, Jonas Thue, 2019, In: Journal of Applied Physiology. 126, 4, p. 993-1005 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Squeezing Flux Out of Fat
Gonzalez-Franquesa, A. & Patti, M., 2018, In: Trends in Endocrinology and Metabolism. 29, 4, p. 201-202Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Quantification of oxidative stress phenotypes based on high-throughput growth profiling of protein kinase and phosphatase knockouts.
Altıntaş, Ali, 11 Nov 2015, In: FEMS Yeast Research.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diabetes mellitus and metabolic syndrome
Ortega, E., Martín-Cordero, L., Garcia-Roves, P. M., Chicco, A. J., Gonzalez-Franquesa, A. & Marado, D., 1 Jan 2015, Biomarkers of Cardiometabolic Risk, Inflammation and Disease. Springer, p. 55-79 25 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2014
- Published
Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice
Zachariah Tom, R., Garcia-Roves, P. M., Sjögren, R. J. O., Jiang, L. Q., Holmström, M. H., Deshmukh, Atul Shahaji, Vieira, E., Chibalin, A. V., Björnholm, M. & Zierath, Juleen R, May 2014, In: Diabetes. 63, 5, p. 1560-71 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle
Montgomery, M. K., Osborne, Brenna, Brown, S. H. J., Small, Lewin Barkla, Mitchell, T. W., Cooney, G. J. & Turner, N., Dec 2013, In: Journal of Lipid Research. 54, 12, p. 3322-3333 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Role of AMPK in IL-6 release from isolated mouse skeletal muscle
Glund, S., Treebak, Jonas Thue, Long, Y. C., Barrès, Romain, Viollet, B., Wojtaszewski, Jørgen F P & Zierath, Juleen R, 2008, In: Diabetologia.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation
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Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
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Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes
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Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation
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Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
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Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
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