- Published
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E., Kanoni, S. & 239 others, , 1 Feb 2016, In: Nature Communications. 7, p. 1-15 15 p., 10495.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
Scott, R. A., Chu, A. Y., Grarup, N., Manning, A. K., Hivert, M-F., Shungin, D., Tönjes, A., Yesupriya, A., Barnes, D., Bouatia-Naji, N., Glazer, N. L., Jackson, A. U., Kutalik, Z., Lagou, V., Marek, D., Rasmussen-Torvik, L. J., Stringham, H. M., Tanaka, T., Aadahl, M., Arking, D. E. & 87 others, , 2012, In: Diabetes. 61, 5, p. 1291-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations
Borisevich, D., Schnurr, T. M., pjx571, pjx571, Rakitko, A., Ängquist, Lars, Ilinsky, V., Aadahl, Mette, Grarup, Niels, Pedersen, Oluf Borbye, Sørensen, Thorkild I.A. & Hansen, Torben, 2021, In: PLoS ONE. 16, 10, 16 p., e0258748.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S. & 31 others, , 2012, In: P L o S Genetics (Online). 8, 3, p. e1002607Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Vogelezang, S., Bradfield, J. P., Ahluwalia, Tarun Veer Singh, Curtin, J. A., Grarup, Niels, Schnurr, T. M., Hansen, Torben, Michaelsen, Kim F., Pedersen, Oluf Borbye, Stokholm, Jakob, Lind, M. V., Frithioff-Bøjsøe, C., Holm, Jens-Christian, Felix, J. F. & Early Growth Genetics Consortium, E. G. G. C., 2020, In: P L o S Genetics. 16, 10, 26 p., e1008718.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality
Ghouse, Jonas, Have, C. T., Skov, M. W., Andreasen, Laura Korsholm, Ahlberg, G., Nielsen, J. B., Skaaby, T., Olesen, Søren-Peter, Grarup, Niels, Linneberg, Allan René, Pedersen, Oluf Borbye, drb459, drb459, Haunsø, Stig, Svendsen, Jesper Hastrup, Hansen, Torben, Kanters, Jørgen K. & Olesen, Morten Steen Salling, May 2017, In: Genetics In Medicine. 19, 5, p. 521-528 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obesity and unfavourable lifestyle increase type 2 diabetes-risk independent of genetic predisposition
Jakupovic, Hermina, Schnurr, T. M., Carrasquilla, Germán D., Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2019, In: Diabetologia. 62, Suppl. 1, p. S188 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study
Schnurr, T. M., Jakupovic, Hermina, Carrasquilla, Germán D., Ängquist, Lars, Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: Diabetologia. 63, 7, p. 1324-1332 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
Jacobsen, P., Grarup, Niels, Tarnow, L., Parving, H. & Pedersen, Oluf Borbye, 2002, In: Nephrology, Dialysis, Transplantation. 17, 8, p. 1408-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Schmidt, A. F., Holmes, M. V., Preiss, D., Swerdlow, D. I., Denaxas, S., Fatemifar, G., Faraway, R., Finan, C., Valentine, D., Fairhurst-Hunter, Z., Hartwig, F. P., Horta, B. L., Hypponen, E., Power, C., Moldovan, M., Van Iperen, E., Hovingh, K., Demuth, I., Norman, K., Steinhagen-Thiessen, E. & 145 others, , 2019, In: BMC Cardiovascular Disorders. 19, 1, 10 p., 240.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity
Lepola, Mette Andersen, Ängquist, Lars, Bork-Jensen, J., Jonsson, Anna Elisabet, Stinson, Sara, Sandholt, C. H., Thodberg, Malte, Pikkupeura, Laura Maarit, Ongstad, E. L., Grarup, Niels, Astrup, A., Pedersen, Oluf Borbye, Williams, K., Barrès, Romain, Sørensen, Thorkild I.A., Linneberg, Allan René, Grimsby, J., Rhodes, C. J. & Hansen, Torben, 2023, In: Diabetes Care. 46, 5, p. 985–992 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers
Schnurr, T. M., Jørsboe, E., Chadt, A., Dahl-Petersen, I. K., Kristensen, Jonas Møller, Wojtaszewski, Jørgen F P, Springer, C., Bjerregaard, P., Brage, S., Pedersen, Oluf Borbye, Moltke, Ida, Grarup, Niels, Al-Hasani, H., Albrechtsen, Anders, Jørgensen, M. E. & Hansen, Torben, 2021, In: Diabetologia. 64, p. 1795-1804Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiologic characterization of type 2 diabetes-related loci
Grarup, Niels, Sparsø, T. & Hansen, Torben, 1 Dec 2010, In: Current Diabetes Reports. 10, 6, p. 485-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polygenic predisposition to breast cancer and the risk of coronary artery disease
D'Souza, M., Schou, Morten, Skals, R., Weeke, P. E., Lee, C., Smedegaard, L., Madelaire, C., Gerds, Thomas Alexander, Poulsen, Henrik Enghusen, Hansen, Torben, Grarup, Niels, Pedersen, Oluf Borbye, Stender, Steen, Engstrøm, Thomas, Fosbøl, E., Nielsen, D., Gislason, Gunnar Hilmar, Køber, Lars Valeur, Torp-Pedersen, C. & Andersson, C., 2019, In: International Journal of Cardiology. 291, p. 145-151 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake
Bojsen-Møller, Kirstine Nyvold, Svane, M. S., Martinussen, C., Dirksen, Carsten Moro, Jørgensen, Nils Bruun, Jensen, Jens-Erik Beck, Jensen, Christian Zinck, Torekov, Signe Sørensen, Kristiansen, V. B., Rehfeld, Jens Frederik, Bork-Jensen, J., Grarup, Niels, Hansen, Torben, Hartmann, Bolette, Holst, Jens Juul & Madsbad, Sten, 2023, In: International Journal of Obesity. 47, 11, p. 1143-1151 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures
Svendstrup, M., Appel, E. V. R., Sandholt, C. H., Ahluwalia, Tarun Veer Singh, Ängquist, Lars, Thuesen, B. H., Jørgensen, M. E., Pedersen, Oluf Borbye, Grarup, Niels, Hansen, Torben, Sørensen, Thorkild I.A. & drb459, drb459, 2018, In: Obesity. 26, 4, p. 747-754 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V., Lu, Y., Highland, H. M., Bang, L. E., Benn, M., Kamstrup, P. R., Bork-Jensen, J., Frikke-Schmidt, R., Gjesing, A. P., Grarup, N., Hansen, T., Have, C. T., Jørgensen, T., Nielsen, S. F., Linneberg, A. R., Pedersen, O., Pers, T. H., Vestergaard, H., Nordestgaard, B., Tybjærg-Hansen, A. & 15 others, , 1 Jan 2018, In: Nature Genetics. 50, p. 26-41 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S., Guo, X., Schurmann, C., Lempradl, A., Marouli, E., Mahajan, A., Winkler, T. W., Locke, A. E., Medina-Gomez, C., Esko, T., Vedantam, S., Giri, A. & 31 others, , 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
Merino, J., Guasch-Ferré, M., Ellervik, C., Dashti, H. S., Sharp, S. J., Wu, P., Overvad, K., Sarnowski, C., Kuokkanen, M., Lemaitre, R. N., Justice, A. E., Ericson, U., Braun, K. V. E., Mahendran, Y., Frazier-Wood, A. C., Sun, D., Chu, A. Y., Tanaka, T., Luan, J., Hong, J. & 48 others, , 2019, In: BMJ (Clinical research ed.). 366, p. l4292Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes
Melchiorsen, Josefine Ulrikke, Sørensen, Kimmie Vestergaard, Bork-Jensen, J., Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt, Hauser, Alexander Sebastian, Rungby, Jørgen, Sørensen, H. T., Vaag, Allan, Nielsen, J. S., Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Gjesing, A. P., Holst, Jens Juul, Hansen, Torben, Rosenkilde, Mette & Grarup, Niels, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare and low-frequency coding variants alter human adult height
Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T. & 31 others, , 9 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes
Hindy, G., Dornbos, P., Chaffin, M. D., Liu, D. J., Wang, M., Selvaraj, M. S., Zhang, D., Park, J., Aguilar-Salinas, C. A., Antonacci-Fulton, L., Ardissino, D., Arnett, D. K., Aslibekyan, S., Atzmon, G., Ballantyne, C. M., Barajas-Olmos, F., Barzilai, N., Becker, L. C., Bielak, L. F., Bis, J. C. & 33 others, , 2022, In: American Journal of Human Genetics. 109, 1, p. 81-96 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare genetic variants previously associated with congenital forms of long QT syndrome have little or no effect on the QT interval
Ghouse, Jonas, Have, C. T., Weeke, P., Nielsen, J. B., Ahlberg, G., Balslev-Harder, M., Appel, E. V., Skaaby, T., Olesen, S., Grarup, Niels, Linneberg, Allan René, Pedersen, Oluf Borbye, Haunsø, Stig, Svendsen, Jesper Hastrup, Hansen, Torben, Kanters, Jørgen K. & Salling Olesen, M., 1 Oct 2015, In: European Heart Journal. 36, 37, p. 2523-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs-Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastian, D., Rodriguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortes-Sánchez, P., González, S., Timshel, P., Pers, T. H., Morgan, C. C., Moran, I., Atla, G., González, J. R., Puiggros, M., Martí, J., Andersson, E. A., Díaz, C. & 23 others, , 22 Jan 2018, In: Nature Communications. 9, 14 p., 321.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes
O'Connor, M. J., Schroeder, P., Huerta-Chagoya, A., Cortés-Sánchez, P., Bonàs-Guarch, S., Guindo Martínez, Marta, Cole, J. B., Kaur, V., Torrents, D., Veerapen, K., Grarup, Niels, Kurki, M., Friis, Carsten, Pedersen, Oluf Borbye, Brandslund, I., Linneberg, Allan René, Hansen, Torben, Leong, A., Florez, J. C. & Mercader, J. M., 2022, In: Diabetes. 71, 3, p. 554–565Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced CD300LG mRNA tissue expression, increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG: a novel genometabolic cross-link between CD300LG and common metabolic phenotypes
Støy, J., Kampmann, U., Mengel, A., Magnusson, N. E., Jessen, N., Grarup, Niels, Rungby, Jørgen, Stødkilde-Jørgensen, H., Brandslund, I., Christensen, C., Hansen, Torben, Pedersen, Oluf Borbye & Møller, N., 2015, In: BMJ open diabetes research & care. 3, 1, p. 1-12 12 p., e000095.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P. & 32 others, , Apr 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
Esserlind, A., Christensen, A. F., Le, H., Kirchmann, M., Hauge, A. W., Toyserkani, N. M., Hansen, Torben, Grarup, Niels, Werge, Thomas, Steinberg, S., Bettella, F., Stefansson, H. & Olesen, Jes, May 2013, In: European Journal of Neurology. 20, 5, p. 765-772 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H., Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T. S., Grarup, N., Guo, Y., Hellman, I., Jin, X., Li, Q., Liu, J., Liu, X., Sparsø, T., Tang, M., Wu, H. & 18 others, , 2010, In: Nature Genetics. 42, 11, p. 969-72 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J-M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K. S., Grarup, N., Jørgensen, T., Brandslund, I., Nielsen, H. B., Juncker, A., dos Santos, M. B. Q., Levenez, F. & 62 others, , 2013, In: Nature. 500, 7464, p. 541-546 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L-P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 31 others, , 2017, In: Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report
Niazi, R. K., Gjesing, A. P., Hollensted, M., Have, C. T., Borisevich, D., Grarup, Niels, Pedersen, Oluf Borbye, Ullah, A., Shahid, G., Shafqat, I., Gul, A. & Hansen, Torben, 2019, In: B M C Medical Genetics. 20, 8 p., 152.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selection in Europeans on fatty acid desaturases associated with dietary changes
Buckley, M. T., Racimo, Fernando, Allentoft, Morten Erik, Jensen, M. K., Jonsson, Anna Elisabet, Huang, H., Hormozdiari, F., Sikora, Martin, Marnetto, D., Eskin, E., Jørgensen, M. E., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Kraft, P., Willerslev, Eske & Nielsen, Rasmus, Jun 2017, In: Molecular Biology and Evolution. 34, 6, p. 1307-1318 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility
Guigas, B., de Leeuw van Weenen, J. E., van Leeuwen, N., Simonis-Bik, A. M., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R. & 15 others, , Aug 2014, In: Diabetic Medicine. 31, 8, p. 1001-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
Williams, K., Ingerslev, L. R., Bork-Jensen, J., Wohlwend, M., Hansen, Ann Normann, Small, Lewin Barkla, Ribel-Madsen, R., Astrup, A., Pedersen, Oluf Borbye, Auwerx, J., Workman, C. T., Grarup, Niels, Hansen, Torben & Barrès, Romain, 2020, In: Nature Communications. 11, 16 p., 2695.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease
Vazquez-Chantada, M., Gonzalez-Lahera, A., Martinez-Arranz, I., Garcia-Monzon, C., Regueiro, M. M., Garcia-Rodriguez, J. L., Schlangen, K. A., Mendibil, I., Rodriguez-Ezpeleta, N., Lozano, J. J., Banasik, K., Justesen, J. M., Jørgensen, T., Witte, D. R., Lauritzen, T., Hansen, T., Pedersen, O., Veyrie, N., Clement, K., Tordjman, J. & 12 others, , Feb 2013, In: Hepatology. 57, 2, p. 505-514 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
Snogdal, L. S., Grarup, Niels, Banasik, Karina, Wod, M., Jørgensen, T., Witte, D. R., Lauritzen, T., Nielsen, A. A., Brandslund, I., Christensen, C., Pedersen, Oluf Borbye, Yderstræde, K. B., Beck-Nielsen, H., Henriksen, J. E., Hansen, Torben & Højlund, K., 25 Oct 2013, In: BMC Medical Genetics. 14, 1, p. 113Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
Burgdorf, K. S., Grarup, Niels, Justesen, Johanne Marie, Harder, M. N., Witte, D. R., Jørgensen, T., Sandbæk, A., Lauritzen, T., Madsbad, Sten, Hansen, Torben, DIAGRAM Consortium, D. C. & Pedersen, Oluf Borbye, 2011, In: P L o S One. 6, 1, p. e15813 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects
Grarup, Niels, Lepola, Mette Andersen, Andreasen, C. H., Albrechtsen, Anders, Borch-Johnsen, K., Jørgensen, T., Auwerx, J., Schmitz, O., Hansen, Torben & Pedersen, Oluf Borbye, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 1, p. 363-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation
Krarup, N. T., Grarup, Niels, Banasik, Karina, Friedrichsen, M., Færch, K., Sandholt, C. H., Jørgensen, T., Poulsen, P., Witte, D. R., Vaag, Allan, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 2012, In: P L o S One. 7, 7, 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism
Metz, Sophia, Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, Christina, Neville, M. J., Christiansen, Malene Revsbech, Jonsson, Anna Elisabet, Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, Niklas Rye, Karpe, F., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 2022, In: Journal of the Endocrine Society. 6, 5, 10 p., bvac034.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge
Andersson, E. A., Harder, M. N., Pilgaard, K., Pisinger, C., Stancáková, A., Kuusisto, J., Grarup, Niels, Færch, K., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Laakso, M., Pedersen, Oluf Borbye & Hansen, Torben, Nov 2011, In: P L o S One. 6, 11, p. e27096 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Middeldorp, C. M., Mahajan, A., Horikoshi, M., Robertson, N. R., Beaumont, R. N., Bradfield, J. P., Bustamante, M., Cousminer, D. L., Day, F. R., De Silva, N. M., Guxens, M., Mook-Kanamori, D. O., St Pourcain, B., Warrington, N. M., Adair, L. S., Ahlqvist, E., Ahluwalia, T. S., Almgren, P., Ang, W., Atalay, M. & 463 others, , 2019, In: European Journal of Epidemiology. 34, 3, p. 279-300 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpeläinen, T. O., Lu, Y., Mägi, R., Mihailov, E., Pers, T. H., Rüeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J. & 31 others, , 1 Oct 2015, In: P L o S Genetics. 11, 10, p. 1-42 42 p., e1005378.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.
Nielsen, T., Burgdorf, K. S., Grarup, Niels, Borch-Johnsen, K., Hansen, T., Jørgensen, T., Pedersen, Oluf Borbye & Andersen, G., 2008, In: Journal of Hypertension. 26, 11, p. 2142-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Vuckovic, D., Bao, E. L., Akbari, P., Lareau, C. A., Mousas, A., Jiang, T., Chen, M-H., Raffield, L. M., Tardaguila, M., Huffman, J. E., Ritchie, S. C., Megy, K., Ponstingl, H., Penkett, C. J., Albers, P. K., Wigdor, E. M., Sakaue, S., Moscati, A., Manansala, R., Lo, K. S. & 31 others, , 2020, In: Cell. 182, 5, p. 1214-1231 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Taste Liking Questionnaire (TasteLQ) – A tool for assessment of taste liking in the Danish population
Haydar, Sara, Karlsson, Camilla Cederbye, Linneberg, Allan René, Kårhus, L. L., Ängquist, Lars, Hansen, Torben, Bredie, Wender & Grarup, Niels, 2024, In: Food Quality and Preference. 117, 12 p., 105176.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Type 2 Diabetes Risk Allele of TMEM154-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes
Balslev-Harder, M., Appel, E. V. R., Grarup, Niels, Gjesing, A. M. P., Ahluwalia, Tarun Veer Singh, Jørgensen, T., Christensen, C., Brandslund, I., Linneberg, Allan René, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 2015, In: PLOS ONE. 10, 3, p. 1-13 13 p., e0120890.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample
Esserlind, A., Christensen, A. F., Steinberg, S., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Werge, Thomas, Hansen, T. F., Husemoen, L. L. N., Linneberg, Allan René, Budtz-Joergensen, Esben, Westergaard, M. L., Stefansson, H. & Olesen, Jes, 2016, In: Cephalalgia : an international journal of headache. 36, 7, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders
Andersen, M. K., Jørsboe, E., Skotte, L., Hanghøj, K., Sandholt, C. H., Moltke, I., Grarup, N., Kern, T., Mahendran, Y., Søborg, B., Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Tiwari, H. K., Feenstra, B., Koch, A., Wiener, H. W., Hopkins, S. E., Pedersen, O., Melbye, M. & 4 others, , 2020, In: PLOS Genetics. 16, 1, 17 p., e1008544.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals
Grarup, Niels, Overvad, M., Sparsø, T., Witte, D. R., Pisinger, C., Jørgensen, T., Yamauchi, T., Hara, K., Maeda, S., Kadowaki, T., Hansen, T. & Pedersen, Oluf Borbye, 2011, In: Diabetologica. 54, 4, p. 789-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of GWAS identified BMI loci on changes in body weight among middle-aged danes during a five year period
Sandholt, C. H., Allin, K. H., Toft, U., Borglykke, A., Ribel-Madsen, R., Sparsø, T. H., Justesen, Johanne Marie, Harder, M. N., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 26 Jun 2013, In: Obesity. 22, 3, p. 901-908 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of an extreme and prolonged population bottleneck on patterns of deleterious variation: insights from the Greenlandic Inuit
Pedersen, C. T., Lohmueller, K. E., Grarup, Niels, Bjerregaard, P., Hansen, Torben, Siegismund, Hans Redlef, Moltke, Ida & Albrechtsen, Anders, Feb 2017, In: Genetics. 205, 2, p. 787-801 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
Overvad, M., Diaz, L. J., Bjerregaard, P., Pedersen, M. L., Larsen, C. V. L., Senftleber, N., Grarup, Niels, Hansen, Torben & Jørgensen, M. E., 2020, In: Scientific Reports. 10, 9 p., 22081.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland
Overvad, M., Díaz, L. J., Bjerregaard, P., Pedersen, M. L., Larsen, C. V. L., Grarup, Niels, Hansen, Torben, Rossing, Peter & Jørgensen, M. E., 2023, In: International Journal of Circumpolar Health. 82, 8 p., 2191406.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of melatonin on incretin hormones: results from experimental and randomized clinical studies
Lauritzen, E. S., Støy, J., Bæch-Laursen, C., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N., Hartmann, Bolette, Holst, Jens Juul & Kampmann, U., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 12, p. e5109-e5123 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17¿636 Danes
Andersen, G., Dalgaard, L. T., Justesen, Johanne Marie, Anthonsen, S., Nielsen, T., Thørner, L. W., Witte, D., Jørgensen, T., Clausen, J. O., Lauritzen, T., Holmkvist, J., Hansen, Torben & Pedersen, Oluf Borbye, 2012, In: International Journal of Obesity.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The genetic architecture of type 2 diabetes
Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., Ma, C., Fontanillas, P., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Fernandez Tajes, J., Highland, H. M. & 281 others, , 4 Aug 2016, In: Nature. 536, 7614, p. 41-47 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load
Hornbak, M., Banasik, Karina, Justesen, Johanne Marie, Krarup, N. T., Sandholt, C. H., Andersson, Åsa, Sandbaek, A., Lauritzen, T., Pisinger, C., Witte, D. R., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 6 Jan 2011, In: BMC Medical Genetics. 12, 1, p. 4 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The power of genetic diversity in genome-wide association studies of lipids
Graham, S. E., Clarke, S. L., Wu, K-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., Trivedi, B. & 504 others, , 2021, In: Nature. 600, p. 675-679Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The trans-ancestral genomic architecture of glycemic traits
Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J. & 31 others, , 2021, In: Nature Genetics. 53, 6, p. 840-860 41 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T. N., Saleheen, D., Lehne, B., Mateo Leach, I., Drong, A. W., Abbott, J., Wahl, S., Tan, S-T., Scott, W. R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T. V. S., Bonder, M. J. & 31 others, , 2015, In: Nature Genetics. 47, 11, p. 1282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J. P., Manning, A. K., Grarup, N., Sim, X., Barnes, D. R., Witkowska, K., Staley, J. R., Tragante, V., Tukiainen, T., Yaghootkar, H., Masca, N., Freitag, D. F., Ferreira, T., Giannakopoulou, O., Tinker, A., Harakalova, M. & 32 others, , 12 Sep 2016, In: Nature Genetics. 48, 10, p. 1151-1161 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
Chen, M-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., Trivedi, B., Jiang, T., Akbari, P., Vuckovic, D., Bao, E. L., Zhong, X., Manansala, R., Laplante, V., Chen, M., Lo, K. S., Qian, H., Lareau, C. A., Beaudoin, M., Hunt, K. A. & 31 others, , 2020, In: Cell. 182, 5, p. 1198-+ 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., Hofmann, O. M. & 31 others, , 1 Jul 2010, In: Nature Genetics. 42, 7, p. 579-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased ß-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort
Harder, M. N., Ribel-Madsen, R., Justesen, Johanne Marie, Sparsø, T., Galijatovic, E. A. A., Grarup, Niels, Jørgensen, T., Linneberg, Allan René, Hansen, Torben & Pedersen, Oluf Borbye, 1 Apr 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 4, p. 801-806Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release
Nielsen, T., Sparsø, T., Grarup, Niels, Jørgensen, T., Pisinger, C. H., Witte, D. R., Hansen, T., Pedersen, Oluf Borbye & Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, D. G. R. A. M. (. C., 1 May 2011, In: Diabetologica. 54, 5, p. 1052-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight
Andersson, E. A., Pilgaard, K., Pisinger, C., Harder, M. N., Grarup, Niels, Faerch, K., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Hansen, Torben & Pedersen, Oluf Borbye, 1 Sep 2010, In: Diabetologia. 53, 9, p. 1908-16 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uncovering the genetic history of the present-day greenlandic population
Moltke, Ida, Fumagalli, M., Korneliussen, Thorfinn Sand, Crawford, J. E., Bjerregaard, P., Jørgensen, M. E., Grarup, Niels, Gulløv, H. C., Linneberg, Allan René, Pedersen, Oluf Borbye, Hansen, Torben, Nielsen, Rasmus & Albrechtsen, Anders, 2015, In: American Journal of Human Genetics. 96, 1, p. 54-69 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts
Friedrich, N., Pietzner, M., Cannet, C., Thuesen, B. H., Hansen, Torben, Wallaschofski, H., Grarup, Niels, Skaaby, T., Budde, K., Pedersen, Oluf Borbye, Nauck, M. & Linneberg, Allan René, 2017, In: PLOS ONE. 12, 3, 17 p., e0173078.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease
Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., Helgadottir, A., Magnusdottir, A., Jonasdottir, A., Gretarsdottir, S., Jonsdottir, I., Steinthorsdottir, V., Rafnar, T., Swinkels, D. W., Galesloot, T. E., Grarup, N., Jørgensen, T., Vestergaard, H., Hansen, T., Lauritzen, T. & 34 others, , 2 Jun 2016, In: New England Journal of Medicine. 374, 22, p. 2131-2141 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people
Boesgaard, T. W., Grarup, Niels, Jørgensen, T., Borch-Johnsen, K., Hansen, Torben, Pedersen, Oluf Borbye & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), M. O. G. A. I. T. C. (., 1 Aug 2010, In: Diabetologia. 53, 8, p. 1647-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population
Li, S., Besenbacher, S., Li, Y., Kristiansen, Karsten, Grarup, Niels, Albrechtsen, Anders, Sparsø, T. H., Korneliussen, Thorfinn Sand, Hansen, Torben, Wang, J., Nielsen, Rasmus, Pedersen, Oluf Borbye, Bolund, L. & Schierup, M. H., 2014, In: European Journal of Human Genetics. 22, p. 1040-1045 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?
Bonnefond, A., Saulnier, P., Stathopoulou, M. G., Grarup, Niels, Ndiaye, N. C., Roussel, R., Nezhad, M. A., Dechaume, A., Lantieri, O., Hercberg, S., Lauritzen, T., Balkau, B., El-Sayed Moustafa, J. S., Hansen, Torben, Pedersen, Oluf Borbye, Froguel, P., Charpentier, G., Marre, M., Hadjadj, S. & Visvikis-Siest, S., Feb 2013, In: P L o S One. 8, 2, p. e55921Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole exome sequencing identified a novel splice donor site variant in interleukin 2 receptor alpha chain
Waheed, N., Naseer, M., Haider, N., Suleman, Sufyan & Ullah, A., 2023, In: Immunogenetics. 75, p. 71-79Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes
Lohmueller, K. E., Sparsø, T. H., Li, Q., Galijatovic, E. A. A., Korneliussen, T. S., Albrechtsen, A., Banasik, K., Grarup, N., Hallgrimsdottir, I., Kiil, K., Oskari Kilpeläinen, T., Krarup, N. T., Pers, T. H., Sanchez, G., Hu, Y., DeGiorgio, M., Jørgensen, T., Sandbæk, A., Lauritzen, T., Brunak, S. & 6 others, , 5 Dec 2013, In: American Journal of Human Genetics. 93, 6, p. 1072-1086 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Most downloads
-
5481
downloads
Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
5235
downloads
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
2449
downloads
Estimation of allele frequency and association mapping using next-generation sequencing data
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Latest publications
Genome-wide association study of preserved ratio impaired spirometry (PRISm)
Research output: Contribution to journal › Journal article › Research › peer-review
Identification of novel homozygous variants in FOXE3 and AP4M1 underlying congenital syndromic anophthalmia and microphthalmia
Research output: Contribution to journal › Journal article › Research › peer-review
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal
Research output: Contribution to journal › Journal article › Research › peer-review