Physiological Control of Metabolic Homeostasis

The strategic objective of this program is to characterize the role of nutrient metabolite sensing and hormone tissuekine signal integration in maintaining metabolic health and as potential targets to treat metabolic disease.

Our overall metabolism is controlled through the integration of a large number of autocrine, paracrine, endocrine, and neuronal signals affecting the function of each of the individual metabolic organs. These signals are generated in metabolic and endocrine cells, where the state of the different types of energy stores, the amount and type of incoming nutrients and, for example, the state of the gut microbiota are sensed.