Thue W. Schwartz
Professor
Schwartz Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- Published
Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28
Kledal, T. N., Rosenkilde, Mette & Schwartz, Thue W., 1998, In: FEBS Letters. 441, p. 209-214Research output: Contribution to journal › Journal article › Research › peer-review
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Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery
Lappa, D., Meijnikman, A. S., Krautkramer, K. A., Olsson, L. M., Aydin, Ö., Van Rijswijk, A. S., Acherman, Y. I. Z., De Brauw, M. L., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Hjorth, Siv Annegrethe, Ji, B., Gerdes, V. E. A., Groen, A. K., Schwartz, Thue W., Nieuwdorp, M., Bäckhed, F. & Nielsen, J., 2023, In: PLoS ONE. 18, 3, 26 p., e0279335.Research output: Contribution to journal › Journal article › Research › peer-review
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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
Engelstoft, M. S., Park, W-M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., Pan, J., Sinz, C. J., Carrington, P. E., Akiyama, T. E., Jones, R. M., Tang, C., Ahmed, K., Offermanns, S., Egerod, K. L., Zigman, J. M. & 1 others, , Nov 2013, In: Molecular Metabolism. 2, 4, p. 376-92 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74
McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Single-chain vascular endothelial growth factor variant with antagonist activity
Boesen, T. P., Soni, B., Schwartz, Thue W. & Halkier, T., 2002, In: Journal of Biological Chemistry. 277, 43, p. 40335-41 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3
Nielsen, S. M., Elling, C. E. & Schwartz, Thue W., 1998, In: European Journal of Biochemistry. 251, p. 217-226Research output: Contribution to journal › Journal article › Research › peer-review
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Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor
Holst, Birgitte, Jensen, S. Z., Elling, C. E., Hjorth, S. A. & Schwartz, Thue W., 1998, In: Molecular Pharmacology. 53, no. 1, p. 166-175Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands
Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2020, In: Current Opinion in Cell Biology. 63, p. 38-48Research output: Contribution to journal › Review › Research › peer-review
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Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119
Engelstoft, M. S., Norn, C., Pedersen, M. H., Holliday, N. D., Elster, L., Lehmann, J., Jones, R. M., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2014, In: British Journal of Pharmacology. 171, 24, p. 5774-89 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural biology: A moving story of receptors
Schwartz, Thue W. & Hubbell, W. L., 2008, In: Nature. 455, 7212, p. 473-4 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural biology: Full monty of family B GPCRs
Schwartz, Thue W. & Frimurer, Thomas Michael, 2017, In: Nature Chemical Biology. 13, 8, p. 819-821Research output: Contribution to journal › Journal article › Research › peer-review
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Structural biology: snapshot of a signalling complex.
Schwartz, Thue W. & Sakmar, T., Sep 2011, In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-based discovery of novel US28 small molecule ligands with different modes of action
Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release
Hamid, Y. H., Vissing, H., Holst, Birgitte, Urhammer, S. A., Pyke, C., Hansen, S. K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, Thue W., Pedersen, O. & Hansen, Torben, 2005, In: Diabetic Medicine. 22, 1, p. 74-80 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthetic G protein-coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
Tough, I. R., Schwartz, Thue W. & Cox, H. M., 2020, In: Neurogastroenterology and Motility. 32, 12, 14 p., e13943.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting CXCR4 in HIV Cell-Entry Inhibition
Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies
Ditzel, H. J., Rosenkilde, Mette, Garred, P., Wang, M., Pedersen, C., Burton, D. R. & Schwartz, Thue W., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, no. 9, p. 5241-5245Research output: Contribution to journal › Journal article › Research › peer-review
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The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins
Rosenkilde, Mette, McLean, K. A., Holst, Peter Johannes & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 31, p. 32524-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The HETE Is on FFAR1 and Pancreatic Islet Cells
Trauelsen, Mette, Lückmann, Michael, Frimurer, Thomas Michael & Schwartz, Thue W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The MicroRNA Repertoire in Enteroendocrine Cells: Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage
Knudsen, L. A., Petersen, N., Schwartz, Thue W. & Egerod, Kristoffer Lihme, Nov 2015, In: Endocrinology. 156, 11, p. 3971-83 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Molecular Diversity of Vagal Afferents Revealed
Egerod, Kristoffer Lihme, Schwartz, Thue W. & Gautron, L., 2019, In: Trends in Neurosciences. 42, 10, p. 663-666Research output: Contribution to journal › Editorial › Research › peer-review
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The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR
Nygaard, R., Nielbo, S., Schwartz, Thue W. & Poulsen, F. M., 2006, In: Biochemistry. 45, 27, p. 8350-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration
Cornelia Peeters, M., Fokkelman, M., Boogaard, B., Egerod, Kristoffer Lihme, van de Water, B., IJzerman, A. P. & Schwartz, Thue W., Dec 2015, In: Cellular Signalling. 27, 12, p. 2579-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor
Hansen, L. V., Groenen, M., Nygaard, R., Frimurer, Thomas Michael, Holliday, N. D. & Schwartz, Thue W., 14 Sep 2012, In: Journal of Biological Chemistry. 287, 38, p. 31973-82 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
Rudenko, Olga, Shang, J., Munk, A., Ekberg, J. P., Petersen, N., Engelstoft, M. S., Egerod, Kristoffer Lihme, Hjorth, Siv Annegrethe, Wu, M., Feng, Y., Zhou, Y., Mokrosinski, J., Thams, P., Reimann, F., Gribble, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Treebak, Jonas Thue, Howard, A. D. & Schwartz, Thue W., 2019, In: Molecular Metabolism. 19, p. 49-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82Research output: Contribution to journal › Journal article › Research › peer-review
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The chemokine system - a major regulator of angiogenesis in health and disease
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95Research output: Contribution to journal › Journal article › Research › peer-review
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The dual nature of the NK-1 receptor
Maggi, C. & Schwartz, Thue W., 1997, In: TIPS - Trends in Pharmacological Sciences. 18, no. 10, p. 351-355Research output: Contribution to journal › Journal article › Research › peer-review
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The first PP supper - Camelot at Bispebjerg
Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. vol. 234, p. 109-21Research output: Contribution to journal › Journal article › Research › peer-review
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The first PP supper--Camelot at Bispebjerg
Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 234, p. 109-21 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus encoded chemokine MC148, inhibits the CCR10 receptor
Lüttichau, H. R., Lewis, I. C., Gerstoft, J. & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31 (4), p. 1217-1220Research output: Contribution to journal › Journal article › Research › peer-review
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The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor
Lüttichau, H. R., Lewis, I. C., Gerstoft, Jan & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31, 4, p. 1217-20 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling
Fraile-Ramos, A., Kledal, T. N., Pelchen-Matthews, A., Bowers, K., Schwartz, Thue W. & Marsh, M., 2001, In: Molecular Biology of the Cell. 12, 6, p. 1737-49 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma
Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. 174, 6, p. 3686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.
Jensen, K., Manfra, D., Grisotto, M., Martin, A., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S., Mar 2005, In: Journal of immunology (Baltimore, Md. : 1950).Research output: Contribution to journal › Journal article › Research › peer-review
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The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposis sarcoma
Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. Vol. 174, no. 6, p. 3686-94Research output: Contribution to journal › Journal article › Research › peer-review
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The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo
Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The minor binding pocket: a major player in 7TM receptor activation
Rosenkilde, Mette, Benned-Jensen, T., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Trends in Pharmacological Sciences. 31, 12, p. 567-574 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation
Lindow, M., Nansen, A., Bartholdy, C., Stryhn, A., Hansen, N. J. V., Boesen, T. P., Wells, T. N. C., Schwartz, Thue W. & Thomsen, Allan Randrup, 2003, In: Journal of Virology. 77, 13, p. 7393-400 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells
Egerod, Kristoffer Lihme, Engelstoft, M. S., Lund, M. L., Grunddal, Kaare Villum, Zhao, M., Barir-Jensen, D., Nygaard, E. B., Petersen, N., Holst, Jens Juul & Schwartz, Thue W., Nov 2015, In: Endocrinology. 156, 11, p. 3909-23 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
Holst, Jens Juul, Ørskov, Cathrine, Nielsen, Olaf & Schwartz, Thue W., 1987, In: F E B S Letters. 211, 2, p. 169-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity
Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis
Holst, Birgitte, Hastrup, H., Raffetseder, U., Martini, L. & Schwartz, Thue W., 2001, In: Journal of Biological Chemistry. 276, 23, p. 19793-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
Mikkelsen, R. B., Arora, Tulika, Trošt, K., Dmytriyeva, O., Jensen, Sune K. , Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, Thomas, van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, Siv Annegrethe, Schwartz, Thue W. & Bäckhed, F., 2022, In: iScience. 25, 12, 29 p., 105683.Research output: Contribution to journal › Journal article › Research › peer-review
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Unique interaction pattern for a functionally biased ghrelin receptor agonist
Sivertsen, B. B., Lang, M., Frimurer, T. M., Holliday, N. D., Bach, Anders, Els, S., Engelstoft, M. S., Petersen, P. S., Madsen, A. N., Schwartz, Thue W., Beck-Sickinger, A. G. & Holst, Birgitte, 10 Jun 2011, In: The Journal of Biological Chemistry. 286, 23, p. 20845-20860 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1–induced satiation
Vana, V., Lærke, M. K., Rehfeld, Jens Frederik, Arnold, M., Dmytriyeva, O., Langhans, W., Schwartz, Thue W. & Hansen, Harald S., 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 268-280Research output: Contribution to journal › Journal article › Research › peer-review
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Validation of chemokine receptors as drug targets
Lüttichau, H. R. & Schwartz, Thue W., 2000, In: Current Opinion in Drug Discovery & Development. 3, no. 5, p. 610-623Research output: Contribution to journal › Journal article › Research › peer-review
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Viral leads for chemokine-modulatory drugs
Lindow, M., Lüttichau, H. R. & Schwartz, Thue W., 2003, In: TIPS - Trends in Pharmacological Sciences. 24, 3, p. 126-30 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Virally encoded 7TM receptors
Rosenkilde, Mette, Waldhoer, M., Lüttichau, H. R. & Schwartz, Thue W., 2001, In: Oncogene. 20, 13, p. 1582-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Virally encoded chemokines and chemokine receptors in the role of viral infections
Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors
Michel, M. C., Beck-Sickinger, A., Cox, H., Doods, H. N., Herzog, H., Larhammer, D., Quirion, R., Schwartz, Thue W. & Westfall, T., 1998, In: Pharmacological Reviews. 50, no. 1, p. 143-150Research output: Contribution to journal › Journal article › Research › peer-review
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Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase
Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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[Fine needle aspiration cytology of mammography screening]
Engvad, B., Laenkholm, A. V., Schwartz, Thue W. & Bak, M., 2009, In: Ugeskrift for læger. 171, 34, p. 2379-2382 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Sun, W., Dong, H., Balaz, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovanicova, Z., Stefanicka, P., Balazova, L., Ding, L., Husted, Anna Sofie, Rudofsky, G., Ukropec, J., Cinti, S., Schwartz, Thue W., Regev, A. & Wolfrum, C., 2020, In: Nature. 587, 31 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ß-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Wierup, N., Sundler, F., Holst, Birgitte & Schwartz, Thue W., 2011, In: International Journal of Endocrinology. 2011, p. 401258Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11601
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
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Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
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