Kei Sakamoto

Kei Sakamoto

Professor

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    1. Published

      Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

      Ahwazi, Danial, Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, Anna Skab, Gräsle, P., Alshuweishi, Y., Treebak, Jonas Thue, Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, Kei, 2021, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. LKB1-dependent signaling pathways

      Alessi, D. R., Sakamoto, Kei & Bayascas, J. R., 31 Jul 2006, In: Annual Review of Biochemistry. 75, p. 137-163 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    3. Published

      The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise

      Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats Gavalda, Clara, Hirshman, M. F., Dufresne, S. D., Sakamoto, Kei, Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 5′ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise

      Aschenbach, W. G., Sakamoto, Kei & Goodyear, L. J., 12 Mar 2004, In: Sports Medicine. 34, 2, p. 91-103 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    5. Effect of AICAR treatment on glycogen metabolism in skeletal muscle

      Aschenbach, W. G., Hirshman, M. F., Fujii, N., Sakamoto, Kei, Howlett, K. F. & Goodyear, L. J., 1 Jan 2002, In: Diabetes. 51, 3, p. 567-573 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Regulation of Dishevelled and β-catenin in rat skeletal muscle: An alternative exercise-induced GSK-3β signaling pathway

      Aschenbach, W. G., Ho, R. C., Sakamoto, Kei, Fujii, N., Li, Y., Kim, Y. B., Hirshman, M. F. & Goodyear, L. J., 17 Jul 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 1, p. E152-E158

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

      Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E. W., Tsou, P. P., White, J. L., Villén, J., Wang, B., Kim, S. R., Sakamoto, Kei, Gygi, S. P., Cantley, L. C., Yaffe, M. B., Shokat, K. M. & Brunet, A., 23 Dec 2011, In: Molecular Cell. 44, 6, p. 878-892 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

      Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Evaluation of approaches to generation of tissue-specific knock-in mice

      Bayascas, J. R., Sakamoto, Kei, Armit, L., Arthur, J. S. C. & Alessi, D. R., 29 Sep 2006, In: Journal of Biological Chemistry. 281, 39, p. 28772-28781 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Static stretch increases c-Jun NH 2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle

      Boppart, M. D., Hirshman, M. F., Sakamoto, Kei, Fielding, R. A. & Goodyear, L. J., 9 Jun 2001, In: American Journal of Physiology - Cell Physiology. 280, 2 49-2, p. C352-C358

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle

      Bouskila, M., Hunter, R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., Van Diepen, J. A., Voshol, P. J., Jensen, J. & Sakamoto, Kei, 3 Nov 2010, In: Cell Metabolism. 12, 5, p. 456-466 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle

      Bouskila, M., Hirshman, M. F., Jensen, J., Goodyear, L. J. & Sakamoto, Kei, 1 Jan 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 1, p. E28-E35

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

      Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

      Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, Kei, Hue, L. & Rider, M. H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 193-203 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

      Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., Viollet, B., Sakamoto, Kei, Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G., 19 Aug 2016, In: Circulation Research. 119, 5, p. 652-665 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Metformin selectively targets redox control of complex I energy transduction

      Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J. T., Kerr, C., Curry, H., Stewart, D., Sakamoto, Kei, Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. & Rena, G., Apr 2018, In: Redox Biology. 14, p. 187-197 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

      Cameron, A. R., Logie, L., Patel, K., Bacon, S., Forteath, C., Harthill, J., Roberts, A., Sutherland, C., Stewart, D., Viollet, B., Sakamoto, Kei, McDougall, G., Foretz, M. & Rena, G., 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1412-1422 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

      Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, Kei, MacKintosh, C., Wang, H. Y. & Chen, S., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

      Chen, Q., Xie, B., Zhu, S., Rong, P., Sheng, Y., Ducommun, S., Chen, L., Quan, C., Li, M., Sakamoto, Kei, MacKintosh, C., Chen, S. & Wang, H. Y., 2017, In: Diabetologia. 60, 2, p. 336-345 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking

      Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, Kei, 5 Jan 2011, In: Cell Metabolism. 13, 1, p. 68-79 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

      Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowka, A., Thapa, A., Macklin, A., Cao, Y., Nguyen-Tu, M. S., Dickerson, M. T., Jacobson, D. A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning, E., Leclerc, I., Bouzakri, K. & 4 others, Sakamoto, Kei, Smith, D. M., Rutter, G. A. & Martinez-Sanchez, A., 2022, In: Diabetes. 71, 7, p. 1525-1545 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

      Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P. & Sakamoto, Kei, Nov 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12374-12391 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

      Coulerie, P., Ratinaud, Y., Moco, S., Merminod, L., Naranjo Pinta, M., Boccard, J., Bultot, L., Deak, M., Sakamoto, Kei, Queiroz, E. F., Wolfender, J. L. & Barron, D., 23 Nov 2016, In: Journal of Natural Products. 79, 11, p. 2856-2864 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells

      De Meester, C., Timmermans, A. D., Balteau, M., Ginion, A., Roelants, V., Noppe, G., Porporato, P. E., Sonveaux, P., Viollet, B., Sakamoto, Kei, Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & Bertrand, L., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 20-29 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

      Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., Lu, R., Sakamoto, Kei & Steinberg, G. R., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, 8 p., e2119824119.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 227976158