Kei Sakamoto

Kei Sakamoto

Professor

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    1 - 25 out of 145Page size: 25
    1. 2024
    2. Published

      The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions

      Lanfranchi, M., Yandiev, S., Meyer-Dilhet, G., Ellouze, S., Kerkhofs, M., Dos Reis, R., Garcia, A., Blondet, C., Amar, A., Kneppers, A., Polvèche, H., Plassard, D., Foretz, M., Viollet, B., Sakamoto, Kei, Mounier, R., Bourgeois, C. F., Raineteau, O., Goillot, E. & Courchet, J., 2024, In: Nature Communications. 15, 17 p., 2487.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b

      Uehara, K., Lee, W. D., Stefkovich, M., Biswas, Dipsikha, Santoleri, D., Whitlock, A. G., Quinn, W., Coopersmith, T., Creasy, K. T., Rader, D. J., Sakamoto, Kei, Rabinowitz, J. D. & Titchenell, P. M., 2024, In: Journal of Clinical Investigation. 134, 7, 13 p., e173782.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2023
    5. Published

      AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion

      Kneppers, A., Ben Larbi, S., Theret, M., Saugues, A., Dabadie, C., Gsaier, L., Ferry, A., Rhein, P., Gondin, J., Sakamoto, Kei & Mounier, R., 2023, In: iScience. 26, 12, 17 p., 108343.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Amino acid homeostasis is a target of metformin therapy

      Forteath, C., Mordi, I., Nisr, R., Gutierrez-Lara, E. J., Alqurashi, N., Phair, I. R., Cameron, A. R., Beall, C., Bahr, I., Mohan, M., Wong, A. K. F., Dihoum, A., Mohammad, A., Palmer, C. N. A., Lamont, D., Sakamoto, Kei, Viollet, B., Foretz, M., Lang, C. C. & Rena, G., 2023, In: Molecular Metabolism. 74, 16 p., 101750.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

      Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, Sakamoto, Kei, 2023, In: Molecular Metabolism. 75, 14 p., 101761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      In Vitro Screening for Probiotic Properties of Lactobacillus and Bifidobacterium Strains in Assays Relevant for Non-Alcoholic Fatty Liver Disease Prevention

      Lopez-Escalera, S., Lund, M. L., Hermes, G. D. A., Choi, Beatrice So-Yun, Sakamoto, Kei & Wellejus, A., 2023, In: Nutrients. 15, 10, 23 p., 2361.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2022
    10. Published

      Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

      Neopane, K., Kozlov, N., Negoita, F., Murray-Segal, L., Brink, R., Hoque, A., Ovens, A. J., Tjin, G., McAloon, L. M., Yu, D., Ling, N. X. Y., Sanders, M. J., Oakhill, J. S., Scott, J. W., Steinberg, G. R., Loh, K., Kemp, B. E., Sakamoto, Kei & Galic, S., 2022, In: Cell Reports. 41, 12, 26 p., 111862.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

      Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowka, A., Thapa, A., Macklin, A., Cao, Y., Nguyen-Tu, M. S., Dickerson, M. T., Jacobson, D. A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning, E., Leclerc, I., Bouzakri, K. & 4 others, Sakamoto, Kei, Smith, D. M., Rutter, G. A. & Martinez-Sanchez, A., 2022, In: Diabetes. 71, 7, p. 1525-1545 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Mechanism of glycogen synthase inactivation and interaction with glycogenin

      Marr, L., Biswas, Dipsikha, Daly, L. A., Browning, C., Vial, S. C. M., Maskell, D. P., Hudson, C., Bertrand, J. A., Pollard, J., Ranson, N. A., Khatter, H., Eyers, C. E., Sakamoto, Kei & Zeqiraj, E., 2022, In: Nature Communications. 13, 1, 14 p., 3372.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

      Sanders, M. J., Ratinaud, Y., Neopane, K., Bonhoure, N., Day, E. A., Ciclet, O., Lassueur, S., Pinta, M. N., Deak, M., Brinon, B., Christen, S., Steinberg, G. R., Barron, D. & Sakamoto, Kei, 2022, In: Journal of Biological Chemistry. 298, 5, 15 p., 101852.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

      Nguyen-Tu, M., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, Kei, Schmoll, D., Smith, D. M., Carling, D. & Rutter, G. A., 2022, In: Diabetologia. 65, p. 997-1011 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      PEN2: Metformin’s new partner at lysosome

      Sakamoto, Kei & Jessen, N., 2022, In: Cell Research. 32, p. 507-508

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

      Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., Lu, R., Sakamoto, Kei & Steinberg, G. R., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, 8 p., e2119824119.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2021
    18. Published

      Skeletal muscle

      Markby, G. R. & Sakamoto, Kei, 1 Jan 2021, Autophagy in Health and Disease. Elsevier, p. 213-225 13 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    19. Published

      A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

      Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, Kei, Salt, I. P. & Göransson, O., 2021, In: Biochemical Journal. 478, 3, p. 633-646 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

      Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W., Sanders, M. J. & 4 others, Descombes, P., Chen, S., Steinberg, G. R. & Sakamoto, Kei, 2021, In: Molecular Metabolism. 51, 18 p., 101228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

      Ahwazi, Danial, Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, Anna Skab, Gräsle, P., Alshuweishi, Y., Treebak, Jonas Thue, Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, Kei, 2021, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2020
    23. Published

      AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

      Dohmen, M., Krieg, S., Agalaridis, G., Zhu, X., Shehata, S. N., Pfeiffenberger, E., Amelang, J., Bütepage, M., Buerova, E., Pfaff, C. M., Chanda, D., Geley, S., Preisinger, C., Sakamoto, Kei, Lüscher, B., Neumann, D. & Vervoorts, J., 2020, In: Nature Communications. 11, 1, 18 p., 1032.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?

      Markby, G. R. & Sakamoto, Kei, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 319, 4, p. E763-E768 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

    25. 2019

    26. AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

      Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P. & Sakamoto, Kei, Nov 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12374-12391 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen

      Shehata, S. N., Deak, M., Collodet, C., Spiegl, S., Geley, S., Sumpton, D. & Sakamoto, Kei, Jul 2019, In: Cellular Signalling. 59, p. 53-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

      Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, Thomas Elbenhardt, Viollet, B., Foretz, M., Gut, P., Sumpton, D. & Sakamoto, Kei, 2019, In: Cellular Signalling. 57, p. 45-57 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 2018

    30. AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

      Gélinas, R., Mailleux, F., Dontaine, J., Bultot, L., Demeulder, B., Ginion, A., Daskalopoulos, E. P., Esfahani, H., Dubois-Deruy, E., Lauzier, B., Gauthier, C., Olson, A. K., Bouchard, B., Des Rosiers, C., Viollet, B., Sakamoto, K., Balligand, J. L., Vanoverschelde, J. L., Beauloye, C., Horman, S. & 1 others, Bertrand, L., 1 Dec 2018, In: Nature Communications. 9, 1, 374.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. The Salt-Inducible Kinases: Emerging Metabolic Regulators

      Sakamoto, Kei, Bultot, L. & Göransson, O., Dec 2018, In: Trends in Endocrinology and Metabolism. 29, 12, p. 827-840 14 p.

      Research output: Contribution to journal › Review › Research › peer-review

    32. Ampk activation by a-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes

      Kopietz, F., Berggreen, C., Larsson, S., Säll, J., Ekelund, M., Sakamoto, Kei, Degerman, E., Holm, C. & Göransson, O., Nov 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 5, p. E1075-E1085

      Research output: Contribution to journal › Journal article › Research › peer-review

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