Kei Sakamoto

Kei Sakamoto

Professor

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    1. 2018

    2. Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

      Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H. & Sakamoto, Kei, 1 Sep 2018, In: Nature Medicine. 24, 9, p. 1395-1406 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

      Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., Screaton, R. A., Sakamoto, Kei, Ryan, D. P., Mino-Kenudson, M., Castillo, C. F. D., Nomura, D. K., Haas, W. & Bardeesy, N., 1 Jul 2018, In: Nature Cell Biology. 20, 7, p. 811-822 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. MiR-184 expression is regulated by AMPK in pancreatic islets

      Martinez-Sanchez, A., Nguyen-Tu, M. S., Cebola, I., Yavari, A., Marchetti, P., Piemonti, L., De Koning, E., Shapiro, A. M. J., Johnson, P., Sakamoto, Kei, Smith, D. M., Leclerc, I., Ashrafian, H., Ferrer, J. & Rutter, G. A., May 2018, In: FASEB Journal. 32, 5, p. 2587-2600 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Metformin selectively targets redox control of complex I energy transduction

      Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J. T., Kerr, C., Curry, H., Stewart, D., Sakamoto, Kei, Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. & Rena, G., Apr 2018, In: Redox Biology. 14, p. 187-197 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress

      Kfoury, A., Armaro, M., Collodet, C., Sordet-Dessimoz, J., Giner, M. P., Christen, S., Moco, S., Leleu, M., de Leval, L., Koch, U., Trumpp, A., Sakamoto, Kei, Beermann, F. & Radtke, F., 1 Mar 2018, In: EMBO Journal. 37, 5, e97673.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

      Hingst, J. R., Bruhn, L., Hansen, M. B., Rosschou, M. F., Birk, Jesper Bratz, Fentz, J., Foretz, M., Viollet, B., Sakamoto, Kei, Færgeman, N. J., Havelund, J. F., Parker, B. L., James, D. E., Kiens, Bente, Richter, Erik A., Jensen, J. & Wojtaszewski, Jørgen F P, 2018, In: Molecular Metabolism. 16, p. 24-34 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. 2017

    9. The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

      Dite, T. A., Ling, N. X. Y., Scott, J. W., Hoque, A., Galic, S., Parker, B. L., Ngoei, K. R. W., Langendorf, C. G., O'Brien, M. T., Kundu, M., Viollet, B., Steinberg, G. R., Sakamoto, Kei, Kemp, B. E. & Oakhill, J. S., 1 Dec 2017, In: Nature Communications. 8, 1, 571.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

      Theret, M., Gsaier, L., Schaffer, B., Juban, G., Ben Larbi, S., Weiss-Gayet, M., Bultot, L., Collodet, C., Foretz, M., Desplanches, D., Sanz, P., Zang, Z., Yang, Lin, Vial, G., Viollet, B., Sakamoto, Kei, Brunet, A., Chazaud, B. & Mounier, R., 3 Jul 2017, In: EMBO Journal. 36, 13, p. 1946-1962 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

      Zibrova, D., Vandermoere, F., Göransson, O., Peggie, M., Mariño, K. V., Knierim, A., Spengler, K., Weigert, C., Viollet, B., Morrice, N. A., Sakamoto, Kei & Heller, R., 15 Mar 2017, In: Biochemical Journal. 474, 6, p. 983-1001 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

      Dixon-Clarke, S. E., Shehata, S. N., Krojer, T., Sharpe, T. D., Von Delft, F., Sakamoto, Kei & Bullock, A. N., 1 Mar 2017, In: Biochemical Journal. 474, 5, p. 699-713 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Corrigendum: SIKs control osteocyte responses to parathyroid hormone

      Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., O'Meara, M. J., Govea, N., Beqo, B., Nishimori, S., Nagano, K., Brooks, D. J., Martins, J. S., Corbin, B., Anselmo, A., Sadreyev, R., Wu, J. Y., Sakamoto, K., Foretz, M., Xavier, R. J. & 6 others, Baron, R., Bouxsein, M. L., Gardella, T. J., Divieti-Pajevic, P., Gray, N. S. & Kronenberg, H. M., 22 Feb 2017, In: Nature Communications. 8, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

      Chen, Q., Xie, B., Zhu, S., Rong, P., Sheng, Y., Ducommun, S., Chen, L., Quan, C., Li, M., Sakamoto, Kei, MacKintosh, C., Chen, S. & Wang, H. Y., 2017, In: Diabetologia. 60, 2, p. 336-345 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2016

    16. Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

      Coulerie, P., Ratinaud, Y., Moco, S., Merminod, L., Naranjo Pinta, M., Boccard, J., Bultot, L., Deak, M., Sakamoto, Kei, Queiroz, E. F., Wolfender, J. L. & Barron, D., 23 Nov 2016, In: Journal of Natural Products. 79, 11, p. 2856-2864 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. SIKs control osteocyte responses to parathyroid hormone

      Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., O'Meara, M. J., Govea, N., Beqo, B., Nishimori, S., Nagano, K., Brooks, D. J., Martins, J. S., Corbin, B., Anselmo, A., Sadreyev, R., Wu, J. Y., Sakamoto, K., Foretz, M., Xavier, R. J. & 6 others, Baron, R., Bouxsein, M. L., Gardella, T. J., Divieti-Pajevic, P., Gray, N. S. & Kronenberg, H. M., 19 Oct 2016, In: Nature Communications. 7, 13176.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle

      Sakakibara, I., Wurmser, M., Dos Santos, M., Santolini, M., Ducommun, S., Davaze, R., Guernec, A., Sakamoto, Kei & Maire, P., 5 Sep 2016, In: Skeletal Muscle. 6, 1, 30.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

      Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., Viollet, B., Sakamoto, Kei, Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G., 19 Aug 2016, In: Circulation Research. 119, 5, p. 652-665 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

      Cameron, A. R., Logie, L., Patel, K., Bacon, S., Forteath, C., Harthill, J., Roberts, A., Sutherland, C., Stewart, D., Viollet, B., Sakamoto, Kei, McDougall, G., Foretz, M. & Rena, G., 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1412-1422 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

      Mottillo, E. P., Desjardins, E. M., Crane, J. D., Smith, B. K., Green, A. E., Ducommun, S., Henriksen, T. I., Rebalka, I. A., Razi, A., Sakamoto, Kei, Schéele, Camilla Charlotte Nielsen, Kemp, B. E., Hawke, T. J., Ortega, J., Granneman, J. G. & Steinberg, G. R., 12 Jul 2016, In: Cell Metabolism. 24, 1, p. 118-129 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems

      Thevenet, J., De Marchi, U., Domingo, J. S., Christinat, N., Bultot, L., Lefebvre, G., Sakamoto, Kei, Descombes, P., Masoodi, M. & Wiederkehr, A., May 2016, In: FASEB Journal. 30, 5, p. 1913-1926 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

      Langendorf, C. G., Ngoei, K. R. W., Scott, J. W., Ling, N. X. Y., Issa, S. M. A., Gorman, M. A., Parker, M. W., Sakamoto, Kei, Oakhill, J. S. & Kemp, B. E., 8 Mar 2016, In: Nature Communications. 7, 10912.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

      Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

      Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, Kei, MacKintosh, C., Wang, H. Y. & Chen, S., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2015

    27. Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16

      Shehata, S. N., Deak, M., Morrice, N. A., Ohta, E., Hunter, R. W., Kalscheuer, V. M. & Sakamoto, Kei, 1 Aug 2015, In: Biochemical Journal. 469, 3, p. 409-420 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

      Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells

      Hunter, R. W., Zeqiraj, E., Morrice, N., Sicheri, F. & Sakamoto, Kei, Apr 2015, In: Protein Expression and Purification. 108, p. 23-29 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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