Thomas Michael Frimurer
Associate Professor
Platforms
Blegdamsvej 3B, Mærsk Tårnet, 6-7-8. sal, 2200 København N.
Member of:
Introductory remarks on publicationslist
Publications: Author or co-author on > 40 papers in peer-reviewed, medium to high profile scientific journals. Involved in innovation and commercialization activities. Patents: Author or co-author on > 15 patents on chemical leads and drug candidates for the treatment of obesity, type-2 diabetes, asthma inflammation and pain. Most recently (Mar. 2014) we patented a strong chemical package on oral available small molecule GPR39 agonists – a potential obesity and type-2 diabetes target. Invited talks: Participated in multiple oral presentations at international and national scientific meetings.
- 2012
- Published
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop
Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors
Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation
Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2.
Rummel, P. C., Thiele, S., Steen, A. M. F., Elder, A., Kolbech, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: British Journal of Pharmacology. 166Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach
Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists
Grimstrup, M., Receveur, J. M., Rist, Ø., Frimurer, Thomas Michael, Nielsen, P. A., Mathiesen, Jesper M. & Högberg, T., 1 Mar 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1638-1641 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2
Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1
Rist, O., Grimstrup, M., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Kostenis, E. & Högberg, T., 4 Dec 2009, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1177-1180 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Phenoxyacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062678 A1Research output: Patent
- Published
Thiazole- and pyrimidineacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062677 A1Research output: Patent
ID: 34520257
Most downloads
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607
downloads
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
141
downloads
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
130
downloads
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Research output: Contribution to journal › Journal article › Research › peer-review
Published