Thomas Michael Frimurer
Associate Professor
Platforms
Blegdamsvej 3B, Mærsk Tårnet, 6-7-8. sal, 2200 København N.
Member of:
Introductory remarks on publicationslist
Publications: Author or co-author on > 40 papers in peer-reviewed, medium to high profile scientific journals. Involved in innovation and commercialization activities. Patents: Author or co-author on > 15 patents on chemical leads and drug candidates for the treatment of obesity, type-2 diabetes, asthma inflammation and pain. Most recently (Mar. 2014) we patented a strong chemical package on oral available small molecule GPR39 agonists – a potential obesity and type-2 diabetes target. Invited talks: Participated in multiple oral presentations at international and national scientific meetings.
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6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists
Ulven, Trond, Little, P. B., Receveur, J., Frimurer, Thomas Michael, Rist, Ø., Nørregaard, P. K., Mathiesen, Jesper M. & Högberg, T., 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 1070-1075 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists
Ulven, Trond, Frimurer, Thomas Michael, Receveur, J., Little, P. B., Rist, Ø., Nørregaard, P. K. & Högberg, T., 2005, In: Journal of Medicinal Chemistry. 48, 18, p. 5684-5697 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A physicogenetic method to assign ligand-binding relationships between 7TM receptors
Frimurer, Thomas Michael, Ulven, Trond, Elling, T. C. E., Gerlach, L. O., Kostenis, E. & Högberg, T., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 16, p. 3707-3712 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625Research output: Patent
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Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach
Thiele, S., Steen, A., Jensen, P. C., Mokrosinski, J., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: Journal of Biological Chemistry. 286, 43, p. 37543-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures
Sørensen, A. B., Madsen, J. J., Frimurer, Thomas Michael, Overgaard, M. T., Gandhi, P. S., Persson, E. & Olsen, O. H., 2019, In: Biophysical Journal. 116, 10, p. 1823-1835Research output: Contribution to journal › Journal article › Research › peer-review
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An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor
Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assessment and Challenges of Ligand Docking into Comparative Models of G-Protein Coupled Receptors
Nguyen, E. D., Meiler, J., Norn, C. & Frimurer, Thomas Michael, 2 Jul 2013, In: PLOS ONE. 8, 7, p. e67302 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network
Valentin-Hansen, L., Frimurer, Thomas Michael, Mokrosinski, J., Holliday, N. D. & Schwartz, Thue W., 2 Oct 2015, In: The Journal of Biological Chemistry. 290, 40, p. 24495-508 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
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Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2
Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042Research output: Contribution to journal › Journal article › Research › peer-review
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Biased and Constitutive Signaling in the CC-Chemokine Receptor CCR5 by manipulating the Interface between Transmembrane Helix 6 and 7
Steen, A., Thiele, S., Guo, D., Gasbjerg, Lærke Smidt, Frimurer, Thomas Michael & Rosenkilde, Mette, 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12511-12521 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast
Bradley, S. A., Lehka, B. J., Hansson, F. G., Adhikari, K. B., Rago, D., Rubaszka, P., Haidar, A. K., Chen, L., Hansen, L. G., Gudich, O., Giannakou, K., Lengger, B., Gill, R. T., Nakamura, Y., de Bernonville, T. D., Koudounas, K., Romero-Suarez, D., Ding, L., Qiao, Y., Frimurer, T. M. & 12 others, , 2023, In: Nature Chemical Biology. 19, 12, p. 1551-1560 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CRTH2 receptor ligands for therapeutic use
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1Research output: Patent
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CRTH2 receptor ligands for therapeutic use - B-series
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E. & Högberg, T., 2005, Patent No. WO 2005/115374 A1Research output: Patent
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Cyclic Quinoline compounds for use in MCH receptor related disorders
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371Research output: Patent
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Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors
Madsen, J. J., Petersen, Jacob Emil, Christensen, D. P., Hansen, J. B., Schwartz, Thue W., Frimurer, Thomas Michael & Olsen, O. H., 2023, In: Journal of Biological Chemistry. 299, 12, 11 p., 105438.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627Research output: Contribution to journal › Journal article › Research › peer-review
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Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
Manfra, O., Van Craenenbroeck, K., Skieterska, K., Frimurer, Thomas Michael, Schwartz, Thue W., Levy, F. O. & Andressen, K. W., Jul 2015, In: A C S Chemical Neuroscience. 6, 7, p. 1206–1218 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists
Grimstrup, M., Receveur, J. M., Rist, Ø., Frimurer, Thomas Michael, Nielsen, P. A., Mathiesen, Jesper M. & Högberg, T., 1 Mar 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1638-1641 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling
Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats
van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
Pedersen, M. H., Bentsen, M. A., Husted, Anna Sofie, Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, Michael, Miller, M. W., Trujillo, M. E., Frimurer, Thomas Michael, Holst, Birgitte, Howard, A. D. & Schwartz, Thue W., Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)
Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids
Nakamura, K., Saredi, G., Becker, J. R., Foster, B. M., Nguyen, N. V., Beyer, T. E., Cesa, L. C., Faull, P. A., Lukauskas, S., Frimurer, Thomas Michael, Chapman, J. R., Bartke, T. & Groth, Anja, 2019, In: Nature Cell Biology. 21, 3, p. 311-318Research output: Contribution to journal › Letter › Research › peer-review
ID: 34520257
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607
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Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
141
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Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
130
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Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Research output: Contribution to journal › Journal article › Research › peer-review
Published