Thue W. Schwartz

Thue W. Schwartz

Professor

Member of:


    1. 1986
    2. Published

      Kredsløbsregulation ved hypovolaemisk shock

      Sander Jensen, K., Secher, Niels H., Rørsgaard, S., Warberg, J., Astrup, A., Christensen, N. J., Giese, J., Schwartz, Thue W. & Bie, P., 1986, In: Ugeskrift for læger. 148, 38, p. 2383-2387 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. 1987
    4. Published

      Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

      Holst, Jens Juul, Ørskov, Cathrine, Nielsen, Olaf & Schwartz, Thue W., 1987, In: F E B S Letters. 211, 2, p. 169-74 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.

      O'Hare, M., Tortora, O., Gether, Ulrik, Nielsen, Henrik & Schwartz, Thue W., Mar 1987, In: Journal of Chromatography.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. 1989
    7. Published

      Release of PYY from pig intestinal mucosa; luminal and neural regulation

      Sheikh, S. P., Holst, Jens Juul, Ørskov, Cathrine, Ekman, R. & Schwartz, Thue W., Dec 1989, In: Regulatory Peptides. 26, 3, p. 253-66 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. 1990
    9. Published

      C-terminal KDEL-modified cystatin C is retained in transfected CHO cells

      Johansen, T. E., Vogel, Lotte & Schwartz, Thue W., 1990, In: Biochemical and Biophysical Research Communications. 172, 3, p. 1384-91 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase

      Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist

      Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. 1991
    13. Published

      Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors

      Johansen, T. E., Schifter, S., Vogel, Lotte, Tolstoy, S. & Schwartz, Thue W., 1991, In: Molecular and Cellular Endocrinology. 82, 1, p. 51-60 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. 1993
    15. Published

      Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides

      Bjørnholm, B., Jørgensen, Flemming Steen & Schwartz, Thue W., 1993, In: Biochemistry. 32, 12, p. 2954-9 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Immunohistochemical and chromatographic Identification of Peptides derived from Proneuropeptide Y in the human frontal Cortex

      Mikkelsen, J. D., Larsen, P. J., Kruse-Larsen, C., O'Hare, M. M. T. & Schwartz, Thue W., 1993, In: Brain Research Bulletin. 31, p. 415-425

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Regional distribution of putative NPY Y*U1 receptors and neurons expressing Y*U1 mRNA in forebrain areas of the rat central nervous system

      Larsen, P. J., Sheikh, S. P., Jakobsen, C. R., Schwartz, Thue W. & Mikkelsen, J. D., 1993, In: European Journal of Neuroscience. Vol 5, p. 1622-37

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. 1995
    19. Published

      Molecular mechanism of action of non-peptide ligands for peptide receptors

      Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. 1997
    21. Published

      7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion

      Schwartz, Thue W., 1997, In: Ugeskrift for læger. 159, p. 1239-1245

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus

      Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands

      Turcatti, G., Drozda, S. E., Chassaing, G., Schwartz, Thue W., Chollet, A., Jensen, S. Z. & Lowe III, J. A., 1997, In: Journal of Biological Chemistry. 272, no. 34, p. 21167-21175

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Dual agonistic and antagonistic proberty of non-peptide angiotensin AT1 ligands: Susceptibility to receptor mutations

      Perlman, S., Costa-Neto, C. M., Miyakawa, A. A., Schambye, H. T., Hjorth, S. A., Paiva, A. C., Rivero, R. A., Greenlee, W. J. & Schwartz, Thue W., 1997, In: Molecular Pharmaceutics. 51, no. 2, p. 301-311

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors

      Elling, C. E., Thirstrup, K., Nielsen, S. M., Hjorth, S. A. & Schwartz, Thue W., 1997, In: Structure. 2, no. 4, p. 76-80

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      How receptor mutagenesis may confirm or confuse receptor classification

      Schwartz, Thue W., Perlman, S., Rosenkilde, Mette & Hjorth, S. A., 1997, In: Annals of the New York Academy of Sciences. 817, p. 71-84

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors

      Elling, C. E., Thirstrup, K., Nielsen, S. M., Hjorth, S. A. & Schwartz, Thue W., 1997, In: Annals of the New York Academy of Sciences. 814, p. 142-151

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4

      Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P. J., Tran, T., Brass, L. F., Rosenkilde, Mette, Schwartz, Thue W., Luther, M. A., Wells, T. N. C., Hoxie, J. A. & March, M., 1997, In: Journal of Cell Biology. 139, no. 3, p. 651-664

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      Plagiarism of the host immune system - lessons about chemokine immunology from viruses

      Wells, T. N. C. & Schwartz, Thue W., 1997, In: Current Opinion in Biotechnology. 8, no. 6, p. 741-748

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist

      Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, Mette, Schwartz, Thue W., Buser, R., Weels, T. N. C. & Proudfoot, A., 1997, In: Kexue (Shanghai). 276, p. 276-279

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      The dual nature of the NK-1 receptor

      Maggi, C. & Schwartz, Thue W., 1997, In: TIPS - Trends in Pharmacological Sciences. 18, no. 10, p. 351-355

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Den normale hjerne: Ny viden på flere fronter

      Pakkenberg, B., Gundersen, H. J. G., Mortensen, Erik Lykke, Lauritzen, Martin, Jeune, B., Regeur, L., West, M. J. & Schwartz, Thue W., 1 Dec 1997, In: Ugeskrift for Laeger. 159, 6, p. 723-727 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. 1998
    34. Published

      Constitutive activity of glucagon receptor mutants

      Hjorth, S. A., Ørskov, Cathrine & Schwartz, Thue W., 1998, In: Molecular Endocrinology. 12, no. 1, p. 78-86

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Differential regulation of CXCR4 and CCR5 endocytosis

      Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors

      Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 1998, In: Journal of Medicinal Chemistry. 41, p. 4911-4914

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

      Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Principles of Agonism - Undressing Efficacy

      Schwartz, Thue W. & Ijzermann, A. P., 1998, In: TIPS - Trends in Pharmacological Sciences. 19, no. 11, p. 433-436

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28

      Kledal, T. N., Rosenkilde, Mette & Schwartz, Thue W., 1998, In: FEBS Letters. 441, p. 209-214

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3

      Nielsen, S. M., Elling, C. E. & Schwartz, Thue W., 1998, In: European Journal of Biochemistry. 251, p. 217-226

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor

      Holst, Birgitte, Jensen, S. Z., Elling, C. E., Hjorth, S. A. & Schwartz, Thue W., 1998, In: Molecular Pharmacology. 53, no. 1, p. 166-175

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies

      Ditzel, H. J., Rosenkilde, Mette, Garred, P., Wang, M., Pedersen, C., Burton, D. R. & Schwartz, Thue W., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, no. 9, p. 5241-5245

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors

      Michel, M. C., Beck-Sickinger, A., Cox, H., Doods, H. N., Herzog, H., Larhammer, D., Quirion, R., Schwartz, Thue W. & Westfall, T., 1998, In: Pharmacological Reviews. 50, no. 1, p. 143-150

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. 1999
    45. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

      Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12322-7 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor

      Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, no. 22, p. 12322-12327

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

      Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. 2000
    50. Published

      A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum

      Lüttichau, H. R., J., S., Boesen, T. P., Johnsen, A. H., Chantry, D., Gerstoft, J. & Schwartz, Thue W., 2000, In: Journal of Experimental Medicine. 191, no. 1, p. 171-80

      Research output: Contribution to journalJournal articleResearchpeer-review

    51. Published

      Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists

      Larson, D. L., Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 2000, In: Journal of Medicinal Chemistry. 43, no. 8, p. 1573-6

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      Disulfide bridge engineering in the tachykinen NK1 receptor

      Elling, C. E., Raffetseder, U., Nielsen, S. M. & Schwartz, Thue W., 2000, In: Biochemistry. 39, no. 4, p. 667-75

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. Published

      Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor

      Costa-Neto, C. M., Miyakawa, A. A., Oliveira, L., Hjorth, S. A., Schwartz, Thue W. & Paiva, A. C., 2000, In: British Journal of Pharmacology. 130, no. 6, p. 1263-8

      Research output: Contribution to journalJournal articleResearchpeer-review

    54. Published

      Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

      Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 58, 2, p. 263-70 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    55. Published

      Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor

      Rosenkilde, Mette & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 57, no. 3, p. 602-9

      Research output: Contribution to journalJournal articleResearchpeer-review

    56. Published

      Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74

      Rosenkilde, Mette, Kledal, T. N., Holst, Peter Johannes & Schwartz, Thue W., 2000, In: Journal of Biological Chemistry. 275, 34, p. 26309-15 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    57. Published

      Validation of chemokine receptors as drug targets

      Lüttichau, H. R. & Schwartz, Thue W., 2000, In: Current Opinion in Drug Discovery & Development. 3, no. 5, p. 610-623

      Research output: Contribution to journalJournal articleResearchpeer-review

    58. 2001
    59. Published

      Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering

      Jensen, K. K., Martini, L. & Schwartz, Thue W., 2001, In: Biochemistry. 40 (4), p. 938-945

      Research output: Contribution to journalJournal articleResearchpeer-review

    60. Published

      MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8

      Lüttichau, H. R., Gerstoft, Jan & Schwartz, Thue W., 2001, In: Journal of Leukocyte Biology. 70, 2, p. 277-82 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    61. Published

      Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine

      Mizoue, L. S., Sullivan, S. K., King, D. S., Kledal, T. N., Schwartz, Thue W., Bacon, K. B. & Handel, T. M., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33906-14 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    62. Published

      Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

      Gerlach, L., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2001, In: Journal of Biological Chemistry. 276 (17), p. 14153-14160

      Research output: Contribution to journalJournal articleResearchpeer-review

    63. Published

      Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100

      Hatse, S., Princen, K., Gerlach, L., Bridger, G., Henson, G., De Clercq, E., Schwartz, Thue W. & Schols, D., 2001, In: Molecular Pharmacology. 60 (1), p. 164-173

      Research output: Contribution to journalJournal articleResearchpeer-review

    64. Published

      Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100

      Hatse, S., Princen, K., Gerlach, L. O., Bridger, G., Henson, G., De Clercq, E., Schwartz, Thue W. & Schols, D., 2001, In: Molecular Pharmacology. 60, 1, p. 164-73 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    65. Published

      The first PP supper - Camelot at Bispebjerg

      Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. vol. 234, p. 109-21

      Research output: Contribution to journalJournal articleResearchpeer-review

    66. Published

      The first PP supper--Camelot at Bispebjerg

      Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 234, p. 109-21 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    67. Published

      The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus encoded chemokine MC148, inhibits the CCR10 receptor

      Lüttichau, H. R., Lewis, I. C., Gerstoft, J. & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31 (4), p. 1217-1220

      Research output: Contribution to journalJournal articleResearchpeer-review

    68. Published

      The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor

      Lüttichau, H. R., Lewis, I. C., Gerstoft, Jan & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31, 4, p. 1217-20 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    69. Published

      The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling

      Fraile-Ramos, A., Kledal, T. N., Pelchen-Matthews, A., Bowers, K., Schwartz, Thue W. & Marsh, M., 2001, In: Molecular Biology of the Cell. 12, 6, p. 1737-49 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    70. Published

      Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity

      Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    71. Published

      Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis

      Holst, Birgitte, Hastrup, H., Raffetseder, U., Martini, L. & Schwartz, Thue W., 2001, In: Journal of Biological Chemistry. 276, 23, p. 19793-9 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    72. Published

      Virally encoded 7TM receptors

      Rosenkilde, Mette, Waldhoer, M., Lüttichau, H. R. & Schwartz, Thue W., 2001, In: Oncogene. 20, 13, p. 1582-93 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    73. 2002
    74. Published

      Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants

      Costa-Neto, C. M., Miyakawa, A. A., Pesquero, J. B., Oliveira, L., Hjorth, S. A., Schwartz, Thue W. & Paiva, A. C. M., 2002, In: Canadian Journal of Physiology and Pharmacology. 80, 5, p. 413-7 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    75. Published

      Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes

      Fraile-Ramos, A., Pelchen-Matthews, A., Kledal, T. N., Browne, H., Schwartz, Thue W. & Marsh, M., 2002, In: Traffic - International Journal of Intracellular Transport. 3, 3, p. 218-32 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    76. Published

      Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

      Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Biological Chemistry. 277, 49, p. 47662-70 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    77. Published

      Molecular structure and function of 7TM/G-protein coupled receptors

      Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84

      Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

    78. Published

      Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities

      Waldhoer, M., Kledal, T. N., Farrell, H. & Schwartz, Thue W., 2002, In: Journal of Virology. 76, 16, p. 8161-8 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    79. Published

      NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype

      Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    80. Published

      Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor

      Heding, A., Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Receptors and Signal Transduction. 22, 1-4, p. 241-52 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    81. Published

      Single-chain vascular endothelial growth factor variant with antagonist activity

      Boesen, T. P., Soni, B., Schwartz, Thue W. & Halkier, T., 2002, In: Journal of Biological Chemistry. 277, 43, p. 40335-41 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    82. 2003
    83. Published

      A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6

      Lüttichau, H. R., Clark-Lewis, I., Jensen, Peter Østrup, Moser, C., Gerstoft, Jan & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, Vol. 278 (13), p. 10928-33 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    84. Published

      High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

      Holst, Birgitte, Cygankiewicz, A., Jensen, T. H., Ankersen, M. & Schwartz, Thue W., 2003, In: Molecular Endocrinology. 17, 11, p. 2201-10 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    85. Published

      Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

      Gerlach, L. O., Jakobsen, J. S., Jensen, K. P., Rosenkilde, Mette, Skerlj, R. T., Ryde, U., Bridger, G. J. & Schwartz, Thue W., 2003, In: Biochemistry. 42, 3, p. 710-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    86. Published

      Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe

      Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    87. Published

      Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

      Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    88. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    89. Published

      The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis

      Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82

      Research output: Contribution to journalJournal articleResearchpeer-review

    90. Published

      The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation

      Lindow, M., Nansen, A., Bartholdy, C., Stryhn, A., Hansen, N. J. V., Boesen, T. P., Wells, T. N. C., Schwartz, Thue W. & Thomsen, Allan Randrup, 2003, In: Journal of Virology. 77, 13, p. 7393-400 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    91. Published

      Viral leads for chemokine-modulatory drugs

      Lindow, M., Lüttichau, H. R. & Schwartz, Thue W., 2003, In: TIPS - Trends in Pharmacological Sciences. 24, 3, p. 126-30 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    92. Published

      Virally encoded chemokines and chemokine receptors in the role of viral infections

      Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    93. 2004
    94. Published

      A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)

      Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    95. Published

      Common structural basis for constitutive activity of the ghrelin receptor family

      Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    96. Published

      Constitutive and regulated activities of virus-encoded 7TM receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76

      Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

    97. Published

      Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation

      Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    98. Published

      Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    99. Published

      Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting

      Heydorn, A., Søndergaard, B. P., Hadrup, N., Holst, Birgitte, Haft, C. R. & Schwartz, Thue W., 2004, In: FEBS Letters. 556, 1-3, p. 276-80 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    100. Published

      Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

      Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Skerlj, R., Bridger, G. & Schols, D., 2004, In: Journal of Virology. 78, 23, p. 12996-3006 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    101. Published

      Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

      Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. VOl. 279, no. 4, p. 3033-41

      Research output: Contribution to journalJournal articleResearchpeer-review

    102. Published

      Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

      Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 4, p. 3033-41 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    103. Published

      Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74

      McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    104. Published

      The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins

      Rosenkilde, Mette, McLean, K. A., Holst, Peter Johannes & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 31, p. 32524-33 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    105. Published

      The chemokine system - a major regulator of angiogenesis in health and disease

      Rosenkilde, Mette & Schwartz, Thue W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95

      Research output: Contribution to journalJournal articleResearchpeer-review

    106. 2005
    107. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    108. Published

      CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor

      Casarosa, P., Waldhoer, M., LiWang, P. J., Vischer, H. F., Kledal, T., Timmerman, H., Schwartz, Thue W., Smit, M. J. & Leurs, R., 2005, In: Journal of Biological Chemistry. 280, 5, p. 3275-3285 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    109. Published

      Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

      Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. 19, 3, p. 812-23 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    110. Published

      Characterizaton of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

      Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. Vol. 19, no.3, p. 812-23

      Research output: Contribution to journalJournal articleResearchpeer-review

    111. Published

      High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3

      Rosenkilde, Mette, Kledal, T. N. & Schwartz, Thue W., 2005, In: Molecular Pharmacology. 68, 1, p. 11-9 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    112. Published

      Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

      Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    113. Published

      Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release

      Hamid, Y. H., Vissing, H., Holst, Birgitte, Urhammer, S. A., Pyke, C., Hansen, S. K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, Thue W., Pedersen, O. & Hansen, Torben, 2005, In: Diabetic Medicine. 22, 1, p. 74-80 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    114. Published

      The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma

      Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. 174, 6, p. 3686-94 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    115. Published

      The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposis sarcoma

      Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. Vol. 174, no. 6, p. 3686-94

      Research output: Contribution to journalJournal articleResearchpeer-review

    116. Published

      The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.

      Jensen, K., Manfra, D., Grisotto, M., Martin, A., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S., Mar 2005, In: Journal of immunology (Baltimore, Md. : 1950).

      Research output: Contribution to journalJournal articleResearchpeer-review

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