Thue W. Schwartz

Thue W. Schwartz

Professor

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    ORCID: 0000-0002-0261-6904

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    1. Published

      7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion

      Schwartz, Thue W., 1997, In: Ugeskrift for læger. 159, p. 1239-1245

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis

      Grevengoed, Trisha Jean, Trammell, Sam, McKinney, M. K., Petersen, N., Cardone, R. L., Svenningsen, J. S., Ogasawara, D., Nexøe-Larsen, C. C., Knop, Filip Krag, Schwartz, Thue W., Kibbey, R. G., Cravatt, B. F. & Gillum, M. P., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24770-24778

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

      Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus

      Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

      Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A gut feeling for obesity: 7TM sensors on enteroendocrine cells

      Engelstoft, M. S., Egerod, Kristoffer Lihme, Holst, Birgitte & Schwartz, Thue W., 2008, In: Cell Metabolism. 8, 6, p. 447-9 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum

      Lüttichau, H. R., J., S., Boesen, T. P., Johnsen, A. H., Chantry, D., Gerstoft, J. & Schwartz, Thue W., 2000, In: Journal of Experimental Medicine. 191, no. 1, p. 171-80

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6

      Lüttichau, H. R., Clark-Lewis, I., Jensen, Peter Østrup, Moser, C., Gerstoft, Jan & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, Vol. 278 (13), p. 10928-33 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)

      Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39

      Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity

      Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, Siv Annegrethe, Gerdes, V. E. A., Schwartz, Thue W., Groen, A. K., Bäckhed, F., Nielsen, J. & Nieuwdorp, M., 2022, In: iScience. 25, 8, 18 p., 104828.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

      Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykko, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, S. & 6 others, Nielsen, J., Schwartz, Thue W., Groen, A. K., Nieuwdorp, M., Backhed, F. & Gerdes, V. E. A., 2021, In: Journal of Internal Medicine. 289, 3, p. 340-354 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

      Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4

      Tang, X., Fuchs, D., Tan, S., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Li, N. & Haeggstrom, J. Z., 2020, In: Journal of Thrombosis and Haemostasis. 18, 4, p. 976-984 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction

      Tang, X., Rönnberg, E., Säfholm, J., Thulasingam, M., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Dahlén, S. E., Nilsson, G. & Haeggström, J. Z., 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 9, p. 2677-2687

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

      Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells

      Grunddal, Kaare Villum, Tonack, S., Egerod, Kristoffer Lihme, Thompson, J. J., Petersen, N., Engelstoft, M. S., Vagne, C., Keinse, C., Gradwohl, G., Offermanns, S. & Schwartz, Thue W., 2021, In: Molecular Metabolism. 51, 17 p., 101231.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors

      Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

      Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

      Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

      Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor

      Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      An enteroendocrine full package solution

      Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

      Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2

      Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network

      Valentin-Hansen, L., Frimurer, Thomas Michael, Mokrosinski, J., Holliday, N. D. & Schwartz, Thue W., 2 Oct 2015, In: The Journal of Biological Chemistry. 290, 40, p. 24495-508 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

      Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa

      Tough, I. R., Forbes, S., Herzog, H., Jones, R. M., Schwartz, Thue W. & Cox, H. M., 1 Apr 2018, In: Endocrinology. 159, 4, p. 1704-1717

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists

      Larson, D. L., Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 2000, In: Journal of Medicinal Chemistry. 43, no. 8, p. 1573-6

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics

      Park, M., Sivertsen, B. B., Els-Heindl, S., Huber, T., Holst, Birgitte, Beck-Sickinger, A. G., Schwartz, Thue W. & Sakmar, T. P., 19 Nov 2015, In: Chemistry & Biology. 22, 11, p. 1431-1436 6 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    31. Published

      Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors

      Tian, H., Naganathan, S., Kazmi, M. A., Schwartz, Thue W., Sakmar, T. P. & Huber, T., 18 Aug 2014, In: ChemBioChem. 15, 12, p. 1820-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      C-terminal KDEL-modified cystatin C is retained in transfected CHO cells

      Johansen, T. E., Vogel, Lotte & Schwartz, Thue W., 1990, In: Biochemical and Biophysical Research Communications. 172, 3, p. 1384-91 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor

      Casarosa, P., Waldhoer, M., LiWang, P. J., Vischer, H. F., Kledal, T., Timmerman, H., Schwartz, Thue W., Smit, M. J. & Leurs, R., 2005, In: Journal of Biological Chemistry. 280, 5, p. 3275-3285 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection

      Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle

      Abdelmoez, A. M., Dmytriyeva, O., Zurke, Y. X., Trauelsen, Mette, Marica, A. A., Savikj, M., Smith, J. A. B., Monaco, C., Schwartz, Thue W., Krook, A. & Pillon, N. J., 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 324, 4, p. E289-E298 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET

      Joergensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Elling, C. E. & Schwartz, Thue W., 2008, In: Molecular Pharmaceutics. 73, 2, p. 349-358 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

      Jorgensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Schwartz, Thue W. & Elling, C. E., 2007, In: Molecular Pharmacology. 73, 2, p. 349-58 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

      Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. 19, 3, p. 812-23 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands

      Turcatti, G., Drozda, S. E., Chassaing, G., Schwartz, Thue W., Chollet, A., Jensen, S. Z. & Lowe III, J. A., 1997, In: Journal of Biological Chemistry. 272, no. 34, p. 21167-21175

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Characterizaton of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype

      Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. Vol. 19, no.3, p. 812-23

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Common structural basis for constitutive activity of the ghrelin receptor family

      Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V

      Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides

      Bjørnholm, B., Jørgensen, Flemming Steen & Schwartz, Thue W., 1993, In: Biochemistry. 32, 12, p. 2954-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

      Nygaard, R., Hansen, L. V., Mokrosinski, J., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 25, p. 19625-36 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Constitutive activity of glucagon receptor mutants

      Hjorth, S. A., Ørskov, Cathrine & Schwartz, Thue W., 1998, In: Molecular Endocrinology. 12, no. 1, p. 78-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Constitutive and regulated activities of virus-encoded 7TM receptors

      Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76

      Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

    47. Published

      Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation

      Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Construction of covalently coupled, concatameric dimers of 7TM receptors

      Terpager, M., Scholl, D. J., Kubale, V., Martini, L., Elling, C. E. & Schwartz, Thue W., 2009, In: Journal of Receptors and Signal Transduction. 29, 5, p. 235-45 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

      Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12322-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor

      Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, no. 22, p. 12322-12327

      Research output: Contribution to journal › Journal article › Research › peer-review

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