GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance
Research output: Contribution to journal › Journal article › Research › peer-review
Subgroups of patients with type 2 diabetes mellitus demand large insulin doses to maintain euglycemia. These patients are characterized by severe skeletal muscle insulin resistance and the underlying pathology remains unclear. The purpose of this study was to examine protein expression of the principal glucose transporter, GLUT4, and associated proteins in skeletal muscle from type 2 diabetic patients characterized by severe insulin resistance.
| Original language | English |
|---|---|
| Journal | PLOS ONE |
| Volume | 6 |
| Issue number | 11 |
| Pages (from-to) | e27854 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 2011 |
| Externally published | Yes |
- Blotting, Western, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Glucose Transporter Type 4, Humans, Insulin Resistance, Male, Middle Aged, Muscle, Skeletal, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ubiquitin-Conjugating Enzymes
Research areas
ID: 101699809