Identification of plasma lipid metabolites associated with nut consumption in US men and women
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Identification of plasma lipid metabolites associated with nut consumption in US men and women. / Malik, Vasanti S.; Guasch-Ferre, Marta; Hu, Frank B.; Townsend, Mary K.; Zeleznik, Oana A.; Eliassen, A. Heather; Tworoger, Shelley S.; Karlson, Elizabeth W.; Costenbader, Karen H.; Ascherio, Alberto; Wilson, Kathryn M.; Mucci, Lorelei A.; Giovannucci, Edward L.; Fuchs, Charles S.; Bao, Ying.
In: Journal of Nutrition, Vol. 149, No. 7, 2019, p. 1215-1221.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Identification of plasma lipid metabolites associated with nut consumption in US men and women
AU - Malik, Vasanti S.
AU - Guasch-Ferre, Marta
AU - Hu, Frank B.
AU - Townsend, Mary K.
AU - Zeleznik, Oana A.
AU - Eliassen, A. Heather
AU - Tworoger, Shelley S.
AU - Karlson, Elizabeth W.
AU - Costenbader, Karen H.
AU - Ascherio, Alberto
AU - Wilson, Kathryn M.
AU - Mucci, Lorelei A.
AU - Giovannucci, Edward L.
AU - Fuchs, Charles S.
AU - Bao, Ying
N1 - Publisher Copyright: © 2019 American Society for Nutrition. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background: Intake of nuts has been inversely associated with risk of type 2 diabetes and cardiovascular disease, partly through inducing a healthy lipid profile. How nut intake may affect lipid metabolites remains unclear. Objective: The aim of this study was to identify the plasma lipid metabolites associated with habitual nut consumption in US men and women. Methods: We analyzed cross-sectional data from 1099 participants in the Nurses' Health Study (NHS), NHS II, and Health Professionals Follow-up Study. Metabolic profiling was conducted on plasma by LC-mass spectrometry. Nut intake was estimated from food-frequency questionnaires. We included 144 known lipid metabolites that had CVs <25%. Multivariate linear regression was used to assess the associations of nut consumption with individual plasma lipid metabolites. Results: We identified 17 lipid metabolites that were significantly associated with nut intake, based on a 1 serving (28 g)/d increment in multivariate models [false discovery rate (FDR) P value <0.05]. Among these species, 8 were positively associated with nut intake [C24:0 sphingomyelin (SM), C36:3 phosphatidylcholine (PC) plasmalogen-A, C36:2 PC plasmalogen, C24:0 ceramide, C36:1 PC plasmalogen, C22:0 SM, C34:1 PC plasmalogen, and C36:2 phosphatidylethanolamine plasmalogen], with changes in relative metabolite level (expressed in number of SDs on the log scale) ranging from 0.36 to 0.46 for 1 serving/d of nuts. The other 9 metabolites were inversely associated with nut intake with changes in relative metabolite level ranging from -0.34 to -0.44. In stratified analysis, 3 metabolites were positively associated with both peanuts and peanut butter (C24:0 SM, C24:0 ceramide, and C22:0 SM), whereas 6 metabolites were inversely associated with other nuts (FDR P value <0.05). Conclusions: A panel of lipid metabolites was associated with intake of nuts, which may provide insight into biological mechanisms underlying associations between nuts and cardiometabolic health. Metabolites that were positively associated with intake of nuts may be helpful in identifying potential biomarkers of nut intake.
AB - Background: Intake of nuts has been inversely associated with risk of type 2 diabetes and cardiovascular disease, partly through inducing a healthy lipid profile. How nut intake may affect lipid metabolites remains unclear. Objective: The aim of this study was to identify the plasma lipid metabolites associated with habitual nut consumption in US men and women. Methods: We analyzed cross-sectional data from 1099 participants in the Nurses' Health Study (NHS), NHS II, and Health Professionals Follow-up Study. Metabolic profiling was conducted on plasma by LC-mass spectrometry. Nut intake was estimated from food-frequency questionnaires. We included 144 known lipid metabolites that had CVs <25%. Multivariate linear regression was used to assess the associations of nut consumption with individual plasma lipid metabolites. Results: We identified 17 lipid metabolites that were significantly associated with nut intake, based on a 1 serving (28 g)/d increment in multivariate models [false discovery rate (FDR) P value <0.05]. Among these species, 8 were positively associated with nut intake [C24:0 sphingomyelin (SM), C36:3 phosphatidylcholine (PC) plasmalogen-A, C36:2 PC plasmalogen, C24:0 ceramide, C36:1 PC plasmalogen, C22:0 SM, C34:1 PC plasmalogen, and C36:2 phosphatidylethanolamine plasmalogen], with changes in relative metabolite level (expressed in number of SDs on the log scale) ranging from 0.36 to 0.46 for 1 serving/d of nuts. The other 9 metabolites were inversely associated with nut intake with changes in relative metabolite level ranging from -0.34 to -0.44. In stratified analysis, 3 metabolites were positively associated with both peanuts and peanut butter (C24:0 SM, C24:0 ceramide, and C22:0 SM), whereas 6 metabolites were inversely associated with other nuts (FDR P value <0.05). Conclusions: A panel of lipid metabolites was associated with intake of nuts, which may provide insight into biological mechanisms underlying associations between nuts and cardiometabolic health. Metabolites that were positively associated with intake of nuts may be helpful in identifying potential biomarkers of nut intake.
KW - Lipid metabolites
KW - Lipidomics
KW - Metabolites
KW - Metabolomics
KW - Nuts
KW - Peanuts
U2 - 10.1093/jn/nxz048
DO - 10.1093/jn/nxz048
M3 - Journal article
C2 - 31095304
AN - SCOPUS:85069267073
VL - 149
SP - 1215
EP - 1221
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 7
ER -
ID: 357993895