Standard
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. / Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O; Sovio, Ulla; Taal, H Rob; Hennig, Branwen J; Bradfield, Jonathan P; St Pourcain, Beate; Evans, David M; Charoen, Pimphen; Kaakinen, Marika; Cousminer, Diana L; Lehtimäki, Terho; Kreiner-Møller, Eskil; Warrington, Nicole M; Bustamante, Mariona; Feenstra, Bjarke; Berry, Diane J; Thiering, Elisabeth; Pfab, Thiemo; Barton, Sheila J; Shields, Beverley M; Kerkhof, Marjan; van Leeuwen, Elisabeth M; Fulford, Anthony J; Kutalik, Zoltán; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Hottenga, Jouke-Jan; Wu, Ying; Raitakari, Olli T; Harder, Marie N; Meirhaeghe, Aline; Ntalla, Ioanna; Salem, Rany M; Jameson, Karen A; Zhou, Kaixin; Hansen, Torben; Jørgensen, Torben; Kilpeläinen, Tuomas O; Pedersen, Louise; Vaag, Allan; Vissing, Nadja Hawwa; Witte, Daniel R; Pedersen, Oluf; Bønnelykke, Klaus; Bisgaard, Hans; Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC).
In:
Nature Genetics, Vol. 45, No. 1, 2013, p. 76-82.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Horikoshi, M, Yaghootkar, H, Mook-Kanamori, DO, Sovio, U, Taal, HR, Hennig, BJ, Bradfield, JP, St Pourcain, B, Evans, DM, Charoen, P, Kaakinen, M, Cousminer, DL, Lehtimäki, T, Kreiner-Møller, E, Warrington, NM, Bustamante, M, Feenstra, B, Berry, DJ, Thiering, E, Pfab, T, Barton, SJ, Shields, BM, Kerkhof, M, van Leeuwen, EM, Fulford, AJ, Kutalik, Z, Zhao, JH, den Hoed, M, Mahajan, A, Lindi, V, Goh, L-K, Hottenga, J-J, Wu, Y, Raitakari, OT, Harder, MN, Meirhaeghe, A, Ntalla, I, Salem, RM, Jameson, KA, Zhou, K
, Hansen, T, Jørgensen, T
, Kilpeläinen, TO, Pedersen, L
, Vaag, A, Vissing, NH, Witte, DR
, Pedersen, O, Bønnelykke, K, Bisgaard, H & Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC) 2013, '
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism',
Nature Genetics, vol. 45, no. 1, pp. 76-82.
https://doi.org/10.1038/ng.2477APA
Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., ... Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC) (2013).
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nature Genetics,
45(1), 76-82.
https://doi.org/10.1038/ng.2477Vancouver
Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ et al.
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nature Genetics. 2013;45(1):76-82.
https://doi.org/10.1038/ng.2477Author
Horikoshi, Momoko ; Yaghootkar, Hanieh ; Mook-Kanamori, Dennis O ; Sovio, Ulla ; Taal, H Rob ; Hennig, Branwen J ; Bradfield, Jonathan P ; St Pourcain, Beate ; Evans, David M ; Charoen, Pimphen ; Kaakinen, Marika ; Cousminer, Diana L ; Lehtimäki, Terho ; Kreiner-Møller, Eskil ; Warrington, Nicole M ; Bustamante, Mariona ; Feenstra, Bjarke ; Berry, Diane J ; Thiering, Elisabeth ; Pfab, Thiemo ; Barton, Sheila J ; Shields, Beverley M ; Kerkhof, Marjan ; van Leeuwen, Elisabeth M ; Fulford, Anthony J ; Kutalik, Zoltán ; Zhao, Jing Hua ; den Hoed, Marcel ; Mahajan, Anubha ; Lindi, Virpi ; Goh, Liang-Kee ; Hottenga, Jouke-Jan ; Wu, Ying ; Raitakari, Olli T ; Harder, Marie N ; Meirhaeghe, Aline ; Ntalla, Ioanna ; Salem, Rany M ; Jameson, Karen A ; Zhou, Kaixin ; Hansen, Torben ; Jørgensen, Torben ; Kilpeläinen, Tuomas O ; Pedersen, Louise ; Vaag, Allan ; Vissing, Nadja Hawwa ; Witte, Daniel R ; Pedersen, Oluf ; Bønnelykke, Klaus ; Bisgaard, Hans ; Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC). / New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. In: Nature Genetics. 2013 ; Vol. 45, No. 1. pp. 76-82.
Bibtex
@article{cf1fb4e989b14c4fb0d8671dcb6ea912,
title = "New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism",
abstract = "Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.",
keywords = "Adult, Birth Weight, Blood Pressure, Body Height, Diabetes Mellitus, Type 2, Female, Fetal Development, Genetic Linkage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Infant, Newborn, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci",
author = "Momoko Horikoshi and Hanieh Yaghootkar and Mook-Kanamori, {Dennis O} and Ulla Sovio and Taal, {H Rob} and Hennig, {Branwen J} and Bradfield, {Jonathan P} and {St Pourcain}, Beate and Evans, {David M} and Pimphen Charoen and Marika Kaakinen and Cousminer, {Diana L} and Terho Lehtim{\"a}ki and Eskil Kreiner-M{\o}ller and Warrington, {Nicole M} and Mariona Bustamante and Bjarke Feenstra and Berry, {Diane J} and Elisabeth Thiering and Thiemo Pfab and Barton, {Sheila J} and Shields, {Beverley M} and Marjan Kerkhof and {van Leeuwen}, {Elisabeth M} and Fulford, {Anthony J} and Zolt{\'a}n Kutalik and Zhao, {Jing Hua} and {den Hoed}, Marcel and Anubha Mahajan and Virpi Lindi and Liang-Kee Goh and Jouke-Jan Hottenga and Ying Wu and Raitakari, {Olli T} and Harder, {Marie N} and Aline Meirhaeghe and Ioanna Ntalla and Salem, {Rany M} and Jameson, {Karen A} and Kaixin Zhou and Torben Hansen and Torben J{\o}rgensen and Kilpel{\"a}inen, {Tuomas O} and Louise Pedersen and Allan Vaag and Vissing, {Nadja Hawwa} and Witte, {Daniel R} and Oluf Pedersen and Klaus B{\o}nnelykke and Hans Bisgaard and {Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC)}",
year = "2013",
doi = "10.1038/ng.2477",
language = "English",
volume = "45",
pages = "76--82",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
AU - Horikoshi, Momoko
AU - Yaghootkar, Hanieh
AU - Mook-Kanamori, Dennis O
AU - Sovio, Ulla
AU - Taal, H Rob
AU - Hennig, Branwen J
AU - Bradfield, Jonathan P
AU - St Pourcain, Beate
AU - Evans, David M
AU - Charoen, Pimphen
AU - Kaakinen, Marika
AU - Cousminer, Diana L
AU - Lehtimäki, Terho
AU - Kreiner-Møller, Eskil
AU - Warrington, Nicole M
AU - Bustamante, Mariona
AU - Feenstra, Bjarke
AU - Berry, Diane J
AU - Thiering, Elisabeth
AU - Pfab, Thiemo
AU - Barton, Sheila J
AU - Shields, Beverley M
AU - Kerkhof, Marjan
AU - van Leeuwen, Elisabeth M
AU - Fulford, Anthony J
AU - Kutalik, Zoltán
AU - Zhao, Jing Hua
AU - den Hoed, Marcel
AU - Mahajan, Anubha
AU - Lindi, Virpi
AU - Goh, Liang-Kee
AU - Hottenga, Jouke-Jan
AU - Wu, Ying
AU - Raitakari, Olli T
AU - Harder, Marie N
AU - Meirhaeghe, Aline
AU - Ntalla, Ioanna
AU - Salem, Rany M
AU - Jameson, Karen A
AU - Zhou, Kaixin
AU - Hansen, Torben
AU - Jørgensen, Torben
AU - Kilpeläinen, Tuomas O
AU - Pedersen, Louise
AU - Vaag, Allan
AU - Vissing, Nadja Hawwa
AU - Witte, Daniel R
AU - Pedersen, Oluf
AU - Bønnelykke, Klaus
AU - Bisgaard, Hans
AU - Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC)
PY - 2013
Y1 - 2013
N2 - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
AB - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
KW - Adult
KW - Birth Weight
KW - Blood Pressure
KW - Body Height
KW - Diabetes Mellitus, Type 2
KW - Female
KW - Fetal Development
KW - Genetic Linkage
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - Infant, Newborn
KW - Male
KW - Meta-Analysis as Topic
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
U2 - 10.1038/ng.2477
DO - 10.1038/ng.2477
M3 - Journal article
C2 - 23202124
VL - 45
SP - 76
EP - 82
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 1
ER -
