Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study
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Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. / Guasch-Ferré, Marta; Hu, Frank B.; Martínez-González, Miguel A.; Fitó, Montserrat; Bulló, Mònica; Estruch, Ramon; Ros, Emilio; Corella, Dolores; Recondo, Javier; Gómez-Gracia, Enrique; Fiol, Miquel; Lapetra, José; Serra-Majem, Lluís; Muñoz, Miguel A.; Pintó, Xavier; Lamuela-Raventós, Rosa M.; Basora, Josep; Buil-Cosiales, Pilar; Sorlí, José V.; Ruiz-Gutiérrez, Valentina; Martínez, J. A.; Salas-Salvadó, Jordi.
In: BMC Medicine, Vol. 12, 78, 2014.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study
AU - Guasch-Ferré, Marta
AU - Hu, Frank B.
AU - Martínez-González, Miguel A.
AU - Fitó, Montserrat
AU - Bulló, Mònica
AU - Estruch, Ramon
AU - Ros, Emilio
AU - Corella, Dolores
AU - Recondo, Javier
AU - Gómez-Gracia, Enrique
AU - Fiol, Miquel
AU - Lapetra, José
AU - Serra-Majem, Lluís
AU - Muñoz, Miguel A.
AU - Pintó, Xavier
AU - Lamuela-Raventós, Rosa M.
AU - Basora, Josep
AU - Buil-Cosiales, Pilar
AU - Sorlí, José V.
AU - Ruiz-Gutiérrez, Valentina
AU - Martínez, J. A.
AU - Salas-Salvadó, Jordi
N1 - Funding Information: We thank all the participants in the PREDIMED study. This study was funded, in part, by the Spanish Ministry of Health (ISCIII), PI1001407, Thematic Network G03/140, RD06/0045, FEDER (Fondo Europeo de Desarrollo Regional), and the Centre Català de la Nutrició de l’Institut d’Estudis Catalans. The Fundación Patrimonio Comunal Olivarero and Hojiblanca SA (Málaga, Spain), California Walnut Commission (Sacramento, CA), Borges SA (Reus, Spain), and Morella Nuts SA (Reus, Spain) donated the olive oil, walnuts, almonds and hazelnuts, respectively, used in the study. None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. CIBERobn is an initiative of ISCIII, Spain.
PY - 2014
Y1 - 2014
N2 - Background: It is unknown whether individuals at high cardiovascular risk sustain a benefit in cardiovascular disease from increased olive oil consumption. The aim was to assess the association between total olive oil intake, its varieties (extra virgin and common olive oil) and the risk of cardiovascular disease and mortality in a Mediterranean population at high cardiovascular risk.Methods: We included 7,216 men and women at high cardiovascular risk, aged 55 to 80 years, from the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter, randomized, controlled, clinical trial. Participants were randomized to one of three interventions: Mediterranean Diets supplemented with nuts or extra-virgin olive oil, or a control low-fat diet. The present analysis was conducted as an observational prospective cohort study. The median follow-up was 4.8 years. Cardiovascular disease (stroke, myocardial infarction and cardiovascular death) and mortality were ascertained by medical records and National Death Index. Olive oil consumption was evaluated with validated food frequency questionnaires. Multivariate Cox proportional hazards and generalized estimating equations were used to assess the association between baseline and yearly repeated measurements of olive oil intake, cardiovascular disease and mortality.Results: During follow-up, 277 cardiovascular events and 323 deaths occurred. Participants in the highest energy-adjusted tertile of baseline total olive oil and extra-virgin olive oil consumption had 35% (HR: 0.65; 95% CI: 0.47 to 0.89) and 39% (HR: 0.61; 95% CI: 0.44 to 0.85) cardiovascular disease risk reduction, respectively, compared to the reference. Higher baseline total olive oil consumption was associated with 48% (HR: 0.52; 95% CI: 0.29 to 0.93) reduced risk of cardiovascular mortality. For each 10 g/d increase in extra-virgin olive oil consumption, cardiovascular disease and mortality risk decreased by 10% and 7%, respectively. No significant associations were found for cancer and all-cause mortality. The associations between cardiovascular events and extra virgin olive oil intake were significant in the Mediterranean diet intervention groups and not in the control group.Conclusions: Olive oil consumption, specifically the extra-virgin variety, is associated with reduced risks of cardiovascular disease and mortality in individuals at high cardiovascular risk.Trial registration: This study was registered at controlled-trials.com (http://www.controlled-trials.com/ISRCTN35739639). International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.
AB - Background: It is unknown whether individuals at high cardiovascular risk sustain a benefit in cardiovascular disease from increased olive oil consumption. The aim was to assess the association between total olive oil intake, its varieties (extra virgin and common olive oil) and the risk of cardiovascular disease and mortality in a Mediterranean population at high cardiovascular risk.Methods: We included 7,216 men and women at high cardiovascular risk, aged 55 to 80 years, from the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter, randomized, controlled, clinical trial. Participants were randomized to one of three interventions: Mediterranean Diets supplemented with nuts or extra-virgin olive oil, or a control low-fat diet. The present analysis was conducted as an observational prospective cohort study. The median follow-up was 4.8 years. Cardiovascular disease (stroke, myocardial infarction and cardiovascular death) and mortality were ascertained by medical records and National Death Index. Olive oil consumption was evaluated with validated food frequency questionnaires. Multivariate Cox proportional hazards and generalized estimating equations were used to assess the association between baseline and yearly repeated measurements of olive oil intake, cardiovascular disease and mortality.Results: During follow-up, 277 cardiovascular events and 323 deaths occurred. Participants in the highest energy-adjusted tertile of baseline total olive oil and extra-virgin olive oil consumption had 35% (HR: 0.65; 95% CI: 0.47 to 0.89) and 39% (HR: 0.61; 95% CI: 0.44 to 0.85) cardiovascular disease risk reduction, respectively, compared to the reference. Higher baseline total olive oil consumption was associated with 48% (HR: 0.52; 95% CI: 0.29 to 0.93) reduced risk of cardiovascular mortality. For each 10 g/d increase in extra-virgin olive oil consumption, cardiovascular disease and mortality risk decreased by 10% and 7%, respectively. No significant associations were found for cancer and all-cause mortality. The associations between cardiovascular events and extra virgin olive oil intake were significant in the Mediterranean diet intervention groups and not in the control group.Conclusions: Olive oil consumption, specifically the extra-virgin variety, is associated with reduced risks of cardiovascular disease and mortality in individuals at high cardiovascular risk.Trial registration: This study was registered at controlled-trials.com (http://www.controlled-trials.com/ISRCTN35739639). International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.
KW - Cardiovascular
KW - Mediterranean Diet
KW - Mortality
KW - Olive oil
KW - PREDIMED
U2 - 10.1186/1741-7015-12-78
DO - 10.1186/1741-7015-12-78
M3 - Journal article
C2 - 24886626
AN - SCOPUS:84900331508
VL - 12
JO - BMC Medicine
JF - BMC Medicine
SN - 1741-7015
M1 - 78
ER -
ID: 347807058